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Strain Detail Sheet

Strain Name:
C57BL/6N-Atm1Brd G3bp1tm1a(KOMP)Wtsi/BayMmucd
Stock Number:
047789-UCD
Citation ID:
RRID:MMRRC_047789-UCD
Other Names:
G3bp1_H12, CSD43818
Major Collection:
KOMP

Strain Information

Gene Details

G3bp1tm1a(KOMP)Wtsi
Name: G3BP stress granule assembly factor 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Knockout-first
G3bp1
Name: G3BP stress granule assembly factor 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Knockout-first
NCBI: 27041
Homologene: 38096

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Atm1Brd
Name: nonagouti; targeted mutation 1, Allan Bradley
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Targeted Mutation
Genetic Alterations

Knockout First(Promoter driven)

KOMP Targeting Strategies

Genotype Determination
Genotyping Protocol
ES Cell Line
JM8A3.N1 derived from C57BL/6N

Strain Description

Phenotype
Phenotyping data may be available at mousephenotype.org.
Mammalian Phenotype Terms
Allelic Composition: Atm1Brd/Atm1Brd (Genetic Background: C57BL/6N-Atm1Brd )
Allelic Composition: Atm1Brd/a (Genetic Background: C57BL/6N-Atm1Brd )
MeSH Terms
  • Alleles
  • Animals
  • Computational Biology
  • Embryonic Stem Cells/cytology
  • Embryonic Stem Cells/metabolism
  • Gene Deletion
  • Gene Knockout Techniques/methods
  • Genes/genetics
  • Genes, Lethal/genetics
  • Genetic Association Studies/methods
  • Genetic Vectors/genetics
  • Genome/genetics
  • Genomics
  • Genotype
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout/genetics
  • Mutagenesis, Insertional/methods
  • Phenotype
  • Polymerase Chain Reaction
  • Rats
Strain Development
ES cell clone EPD0551_4_H12 was injected into morulae or blastocysts. Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1a (Knockout First) animals were generated.The MMRRC will use C57BL/6N females for cryo-recovery.
Suggested Control Mice
C57BL/6N or wild-type from colony

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.

Strain Origin

Donor
The KOMP Repository, University of California, Davis; Originating from Arthur Beaudet, Baylor College of Medicine
Primary Reference
Skarnes, W.C., Rosen, B., West, A.P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A.O., Thomas, M., Harrow, J., Cox, T. et al. (2011) A conditional knockout resource for the genome-wide study of mouse gene function. Nature, 474, 337-342. (PMID: 21677750)

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@ucdavis.edu

Appearance

Coat Color
black or agouti

Breeding

MMRRC Breeding System
Backcross or Sib-Mating

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

Distribution of this strain requires submission of the KOMP MTA. The MTA should be signed by an authorized official from your institution, generally this is someone in your Technology Transfer or Intellectual Property offices. A link to this form will be provided via email when an order is submitted; the PDF form should be downloaded or the email forwarded to the appropriate institutional representative for completion following directions in the document.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.