The MMRRC distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. We are a national network of breeding and distribution facilities plus an information coordinating center, serving together as NIH's premier repository of spontaneous and induced mutant mouse and cell lines. The MMRRC is supported by the National Institutes of Health.
The MMRRC is committed to upholding the highest standards of experimental design and quality control to optimize the reproducibility of research studies using mutant mice. If research is to be reliable and reproducible, specific quality control and assurance testing need to be in place. This is why mouse models available from the MMRRC repository are annotated with well documented genetic backgrounds. Furthermore, because of our commitment to maintaining specific-pathogen-free vivaria and quality control measures, investigators can rely on mice obtained from the MMRRC to generate robust and reproducible results.
Strains of mice are maintained in a cryopreserved state unless demand warrants that a live colony be established. Live mice are supplied from a production colony, from a colony recovered from cryopreservation, or via micro-injection of a cell line into host blastocysts. At its option, an MMRRC facility may offer cryopreserved material for resuscitation at the recipient scientist's institution. The MMRRC charges fees to partially cover repository costs; please see our Fees page for details.
In addition, the MMRRC member facilities develop new technologies to improve the handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.