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The purpose of this page is to outline and describe best practices that guide the operations, management, decision-making, and future planning of the Mutant Mouse Research and Resource Center (MMRRC) Consortium. In this context, best practices are defined as actions, procedures, methods, and/or processes that have proven to be most effective in evaluating, maintaining, verifying, and distributing mutant and other mouse models for biomedical research. MMRRC best practices consider all relevant aspects of species-specific biology, physiology, and behavior, are based on the best available scientific evidence or accepted practices and include strategies to minimize potential adverse impact of conditions and procedures on animal care and welfare, safety, recoverability, utility and reliability of mouse resources for rigorous and reproducible biomedical research. Areas of MMRRC Consortium activities guided by best practice principles include 1) Identification and nomenclature, 2) Husbandry, welfare, and protection from adventitious pathogens, 3) Genotype and/or phenotypic verification, 4) Integrity and reliability of cryopreservation and cryorecovery processes and safety and sustainability of the cryoarchive, 5) Relevance and relatedness to biology and/or disease research, 6) Fulfillment of ARRIVE2 and PREPARE guidelines for animals used for research, and 7) Scientific and technical support and breadth and depth of extended resources for users. MMRRC best practices are overseen, written, reviewed, and revised by the MMRRC Rigor and Reproducibility Committee.