In order to better serve the research community, the MMRRC also accepts strains on a fee-for-service basis; mechanisms include:
For NIH pre-authorized submissions, an institute Program Officer works with the MMRRC's DPCPSI program officer to arrange for a number of submission slots that the NIH institute wishes to sponsor. After DPCPSI approval, the sponsoring NIH institute selects the strains and informs the Donating Investigators to proceed with their applications as NIH-preauthorized submissions.
Other agencies, institutions or consortia may also arrange for a submission of multiple lines. The funding entity works with the DPCPSI program officer or directly with one of the MMRRC facilities to contract for a number of slots. While these contract agreements are reviewed by the MMRRC's Coordinating Committee, the funding entity proposes the mouse lines for deposition at the MMRRC. Sponsored submissions are not individually evaluated at the MMRRC's Strain Reviews and are not required to meet the same standards for scientific value required of unfunded submissions which are preserved using DPCPSI's MMRRC grant funding.
Additionally, individual researchers with funding in their grant budget for the sharing of generated mouse resources may arrange for depositing their mouse line with the MMRRC. Individual donors may either indicate on their submission application the available funding, or work directly with any of the MMRRC facilities to arrange a fee-for-service deposition.
Fees for archiving a mouse line for distribution to the research community are based on the specific services requested and the estimated costs of importing, preserving and maintaining the strain at the facility. Each MMRRC facility offers various specialties and services; see the specific services provided by each facility using the list to the left of the main Functions and Services page. The range of costs to deposit a strain with the MMRRC is $2,000 to $8,000; this includes importation, cryopreservation and genotype confirmation. The donating investigator is expected to pay shipping. The MMRRC recommends donors budget for the higher amount in their grant applications. While actual cryopreservation costs may be lower, e.g. if sperm cryopreservation is possible, the higher figure represents costs that could be incurred with a line that has poor breeding characteristics or complex genetic components requiring embryo cryopreservation and complex genotyping assay validation and testing. Once a Donating Investigator is ready to cryopreserve their model, they should contact Customer Service to request a contract submission. The Donating Investigator will then be contacted by the MMRRC facilities with specific fee and service information. The Donating Investigator can then choose which of the facilities they want to work with to deposit their strain.
The MMRRC is not liable for any expenses incurred should the strain become unavailable due to ownership or distribution rights by any third parties or due to any subsequent decision by the donating investigator or their institution.