This June during Alzheimer’s Awareness Month, the NIH is encouraging people to learn more about Alzheimer’s, share their stories, and take action to fight the disease. For more information on Alzheimer’s disease, visit the NIH’s official website.

https://www.nia.nih.gov/health/alzheimers

Popular MMRRC Alzheimer’s Awareness Month Strains

• B6;SJL-Nos2⁺ Tg(APPSWE)2576Kha Tg(PSEN1)1Zhe/Mmnc/Mmnc
• B6;SJL-Nos2^tm1Mrl Tg(APPSWE)2576Kha Tg(PSEN1)1Zhe/Mmnc/Mmnc
• B6;129-Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
• B6.129-Tg(APPSw)40Btla/Mmjax
• B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
• B6.129S4-Tg(APPSwLon)96Btla/Mmjax
• 129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax
• D2.129(B6)-Tg(APPSw)40Btla/Mmjax
• B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
• A.129(B6)-Tg(APPSw)40Btla/Mmjax
• B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
• B6.Cg-Mapt^tm1Hnd Tg(Thy1-MAPT*)3608Gds/Mmjax
• B6.Cg-Mapt^tm1Hnd Tg(Thy1-MAPT*)3610Gds/Mmjax

Contact us if you need assistance with learning more about strains related to Alzheimer in the MMRRC repository.

This May during Cystic Fibrosis Awareness Month, the NIH is encouraging the public to support their mission to cure Cystic Fibrosis by participating in walks and sharing facts about the disease on social media. For more information on Cystic Fibrosis, visit the NIH’s official website.

https://ghr.nlm.nih.gov/condition/cystic-fibrosis

Popular MMRRC Cystic Fibrosis Awareness Month Strains

• C.129P2(Cg)-Cftr^tm1Unc/Mmnc
• D2.129P2(Cg)-Cftr^tm1Unc/Mmnc

Contact us if you need assistance with learning more about strains related to Cystic Fibrosis in the MMRRC repository.

The MMRRC is excited to announce the upcoming release of our newly redesigned submission form set for debut on Wednesday, May 2nd 2018.

Along with user-friendly navigation the form has been significantly reduced to only include the bare minimum criteria needed for strain acceptance. The new design allows users to navigate through the submission form easily and effectively with informative tool-tips to help explain and clarify questions.

Our new shorter form will reduce completion time significantly and make multiple submissions a much simpler process. We anticipate a smooth transition over and look forward to hearing your feedback!

This April during Parkinson’s Awareness Month, the NIH is conducting a campaign to gain support for the one million Americans affected by Parkinson’s disease. For more information on Parkinson’s disease, visit the NIH’s official website.

https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page

Popular MMRRC Parkinson’s Awareness Month Strains

• B6.129-Dnajc6^tm1Legr/Mmjax

Contact us if you need assistance with learning more about strains related to Parkinson’s disease in the MMRRC repository.

This March during Brain Injury Awareness Month, the NIH is conducting a campaign that is aimed at educating the general public about the incidence of brain injuries and the needs of people with brain injuries. For more information on traumatic brain injuries, visit the NIH’s official website.

https://www.ninds.nih.gov/Disorders/All-Disorders/Traumatic-Brain-Injury-Information-Page

Popular MMRRC Brain Injury Awareness Month Strains:

• B6.129S6-Kcnk2^tm1Lex/Mmucd
• B6.Cg-Sod1^tm1Cje/Mmmh
• B6;129-Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}/Mmjax

Contact us if you need assistance with learning more about strains related to brain injuries in the MMRRC repository.

This February during American Heart Month, the NIH is encouraging people to take charge of their health and start new, heart-healthy behavior that can help reduce their risk of heart disease and stroke. For more information, visit the NIH’s official website.

https://www.nhlbi.nih.gov/health/educational/hearttruth/lower-risk/what-is-heart-disease.htm.

Popular MMRRC Heart Month Strains:

• D2.C3-Tg(Myh6-Ngfb)4Fed/Mmmh
• B6.129S7-Chrnb4^tm1Mdb/Mmnc
• B6;129P2-Pde4d^tm1Mct/Mmucd

Contact us if you need assistance with learning more about strains related to heart disease in the MMRRC repository.

Representatives from the MMRRC will be attending American Society of Human Genetics 2017 October 17 – 21 in Orlando FL. Please be sure to stop by our education and outreach booth and learn more about how the MMRRC can help you with your mouse related research needs.

http://www.ashg.org/2017meeting/

Representatives from the MMRRC will be attending Society for Neuroscience 2017 November 11 – 15 in Washington, DC. Please be sure to stop by our education and outreach booth and learn more about how the MMRRC can help you with your mouse related research needs.

https://www.sfn.org/annual-meeting/neuroscience-2017

Representatives from the MMRRC will be attending Experimental Biology 2017 April 22 – 26 in Chicago, IL. Please be sure to stop by booth #1412 and learn more about how the MMRRC can help you with your mouse related research needs.

http://experimentalbiology.org/2017/Home.aspx

The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterizing them through standardized, quality-controlled phenotyping tests.

IMPC Flyer

Since 2006, researchers around the world have been working together to generate a targeted knockout mutation for every gene in the mouse genome. The US component of this effort, The Knockout Mouse Project (KOMP), has been providing critical tools for understanding gene function and the genetic causes of human diseases.

In 2016, the National Institutes of Health funded the next phase in the KOMP project called KOMP2 Phase 2 with the objective to produce and phenotype more than 3000 new knockout mouse lines on a C57BL6/N genetic background. Here at the MMRRC, we are pleased to announce that these KOMP2 Phase2 mouse lines will all be made available from the MMRRC repositories. New mouse lines will be added monthly and full phenotyping data will be available.

Genetically engineered mice serve as valuable models of human disease, contributing to major medical breakthroughs. Often, biomedical researchers must develop unique genetically modified strains of mice for experimentation, a costly and time-consuming process. Now, more researchers in fields from immunology to cancer may be able to save time and money by acquiring genetic material from a repository of previously engineered strains.

https://www.niaid.nih.gov/news-events/niaid-supported-research-expands-number-publicly-available-mouse-mutations

Representatives from the MMRRC will be attending The Allied Genetics Conference July 13 – 17 in Orlando FL. Please be sure to stop by our booth and learn more about how the MMRRC can help you with your mouse related research needs. http://www.genetics2016.org

Representatives from the MMRRC will be attending Society for Neuroscience 2016 November 13 –16 in San Diego, CA. Please be sure to stop by booth #4322 and learn more about how the MMRRC can help you with your mouse related research needs. https://www.sfn.org/annual-meeting/neuroscience-2016

Representatives from the MMRRC will be attending Experimental Biology 2016 April 2 – 6 in San Diego CA. Please be sure to stop by booth #1104 and learn more about how the MMRRC can help you with your mouse related research needs. http://experimentalbiology.org/2016/Home.aspx

Representatives from the MMRRC will be attending American Society for Human Genetics 2016 October 18 – 22 in Vancouver, BC. Please be sure to stop by booth #422B and learn more about how the MMRRC can help you with your mouse related research needs.
http://www.ashg.org/2016meeting/

Read the recently published article in Nature about how the MMRRC repository provides scientific value and utility through curation, preservation, genetic quality control, and protection from pathogens.  Learn about the efforts that the MMRRC takes to help researchers reduce model redundancy and improve reproducibility of studies. http://www.nature.com/news/reproducibility-use-mouse-biobanks-or-lose-them-1.17707

Representatives from the MMRRC will be attending the 66th Annual AALAS National Meeting November 1-5, 2015 Phoenix, AZ. Please be sure to stop by booth #215 and learn more about how the MMRRC can help you with your mouse related research needs. https://www.aalas.org/national-meeting#.VRrfaE10y70

Representatives of the Mutant Mouse Regional Resource Center will be attending the American Society of Cell Biology Meeting in Philadelphia December 6-10. Please come by booth #916 and let us help you with your mouse research needs.

The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). The dkNET portal contains information about research resources such as antibodies, vectors and mouse strains, data, protocols, and literature.

The MMRRC is pleased to officially announce the release of our newly redesigned order process! Along with user-friendly navigation and the new "Favorites" feature, the order form has been updated with the latest information and a fresh new look. The new design allows users to navigate through the order process easily and effectively with alerts for missed questions, in-line hints, and the ability to alter contact information within the form. The new Favorites feature allows users to save and organize their favorite products and even allows them to send their favorites list to their registered email account for later reference.

April 26 – 30
Experimental Biology
Booth 1439
San Diego, CA, San Diego Convention Center
http://experimentalbiology.org/2014/Home.aspx

October 18 - 22
American Society Human Genetics
Booth TBD
San Diego, CA, San Diego Convention Center
http://www.ashg.org/2014meeting

November 15 – 19
Neuroscience
Booth TBD
Washington, DC, Walter E. Washington Convention Center
http://www.sfn.org/annual-meeting/neuroscience-2014

December 6 - 10
American Society Cell Biology
Booth TBD
Pennsylvania, PA, Pennsylvania Convention Center
http://www.ascb.org/meetings-home

The Mutant Mouse Regional Resource Center (MMRRC) will be attending the 2013 American Society for Cell Biology Meeting December 14 through 18 in New Orleans. The MMRRC has been able to map 900 MeSH terms from attendee publications to mouse models within our repositories. If you are attending the meeting, then please consider visiting our booth and speaking directly with one of our knowledgeable customer service staff members.

The Mutant Mouse Regional Resource Center (MMRRC) repository simple and advanced search methods now include the ability to search by associated Major Medical Subject Heading (MeSH) terms. MeSH is the National Library of Medicine\'s controlled vocabulary thesaurus. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity. Major MeSH terms are defined by authors of primary research articles as having the most relevance to the research represented by the article.

The Mutant Mouse Regional Resource Center (MMRRC) will be attending the Society of Neuroscience Meeting in San Diego November 9-13 (booth 3831). Among the thousands of model systems within the MMRRC repository, the MMRRC has 440 neuroscience models in 700 major Medical Subject Heading (MeSH) categories. If you are attending the meeting, then please consider visiting our booth (#3831) and speaking directly with one of our knowledgeable customer service staff members.

The International Mouse Phenotyping Consortium is conducting a survey with the goal of exploring ways to ensure that researchers utilize high-impact mouse-model resources. The on line survey is available here.

When expressed in mice, high levels of Neuregulin 1 (Nrg1) lead to behavioral deficits and hypofunction of glutamatergic and GABAergic pathways similar to that found in human patients with schizophrenia. Don-Yin Min, et al. found that these effects are diminished when Nrg1 levels are returned to normal.

The MMRRC has related mouse models.

Evidence that that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM.
Full publiceation here.

The MMRRC has a related ES cell line.

Researchers at UT Southwestern Medical Center have identified a specific gene, Meis1 that regulates the heart’s ability to regenerate after injuries. The original article can be found in Nature.

The MMRRC has a GENSAT mouse containing multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the Meis1 coding sequence of the targeted gene.

In 2012, the MMRRC was able to successfully deliver 246 out of 247 resuscitation orders. Please consider our services to best meet your research needs.

Scientists Make Mouse Model of Human Cancer, Demonstrate Cure
UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer. Blocking the activity of a receptor molecule named CXCR4 inhibited tumor development of malignant peripheral nerve sheath tumors (MPNSTs).

STOCK Tg(Cxcr4-EGFP)CD73Gsat/Mmucd is available from the MMRRC and contains multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the coding sequence of the targeted gene.

In an effort to determine MMRRC's contribution to biomedical research, we reached out to all our previous customers and asked for additional information on previous orders. Customers who filled out the raffle form with valid NIH Grant entries and/or Pubmed publication IDs were entered into a raffle with a chance to win a new iPod. The raffle winner was selected today. Congratulations to Dr. Caius G. Radu from University of California, Los Angeles for winning the iPod. We would like to thank all those who participated in this raffle and provided valuable information about their past purchases from MMRRC. We appreciate their time and effort.

Brain diseases associated with the misformed protein tau, including Alzheimers disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological tau filaments.  article  Mapt at MMRRC

Our very own Terry R. Magnuson, Ph.D., Sarah Graham Kenan Professor and chair, department of genetics, and vice dean for research, School of Medicine, University of North Carolina, Chapel Hill, and Project Director for the MMRRC at North Carolina-Chapel Hill, was just elected to the Institute of Medicine of the National Academies.

Welcome to the newly revised MMRRC website! The goal of this revision is to modernize the look and feel of MMRRC's web presence. We hope the new simplified search feature will make finding the products you are looking for easier. For any questions/problems you have regarding this release, please email us at service@mmrrc.org, or use the Feedback function to the right side of the page.