MMRRC Repository

We archive biomedically valuable mice and ES cell lines.

We conduct research relevant to MMRRC's resources

We provide mice and ES cell lines to researchers worldwide

Newly available/Recently accepted Retiring Colonies

FREE NIH sponsored Symposium on Precision Mouse Modeling: Translation to Human Disease 9/11/2019

Come learn from leading scientific researchers about the latest developments and research surrounding Precision Mouse Modeling as it translates to Human Disease. Sponsored by the NIH, ORIP, this information symposium will be held from 1:30pm – 5pm on September 11 at Monsanto Auditorium of the Bond Life Science Center on the University of Missouri-Columbia.

MMRRC Symposium Flyer

August is Spinal Muscular Atrophy Awareness Month

This August during Spinal Muscular Atrophy Awareness Month, the NIH is raising a public health campaign to spread awareness of spinal muscular atrophy and the availability of carrier screening. For more information on Spinal Muscular Atrophy, visit the NIH’s official website:

https://www.ninds.nih.gov/Disorders/All-Disorders/Spinal-Muscular-Atrophy-Information-Page

Popular MMRRC Spinal Muscular Atrophy Awareness Month Strains:

Contact us if you need assistance with learning more about strains related to Spinal Muscular Atrophy in the MMRRC repository.

June is Alzheimer’s Awareness Month

June is Alzheimer’s Awareness Month, and a popular research area for MMRRC strains to study the disease. For more information on Alzheimer’s disease, visit the NIH’s official website:

https://www.nia.nih.gov/health/alzheimers

Popular MMRRC Alzheimer’s Awareness Month Strains:

May is Cystic Fibrosis Awareness Month

This May during Cystic Fibrosis Awareness Month, the NIH is encouraging the public to support their mission to cure Cystic Fibrosis by participating in walks and sharing facts about the disease on social media. For more information on Cystic Fibrosis, visit the NIH’s official website:

https://ghr.nlm.nih.gov/condition/cystic-fibrosis

Popular MMRRC Cystic Fibrosis Awareness Month Strains:

April is Parkinson’s Awareness Month

This April during Parkinson’s Awareness Month, the NIH is conducting a campaign to gain support for the one million Americans affected by Parkinson’s disease. For more information on Parkinson’s disease, visit the NIH’s official website:

https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page

Popular MMRRC Parkinson’s Awareness Month Strains:

B6.129-Dnajc6^tm1Legr/Mmjax

Contact us if you need assistance with learning more about strains related to Parkinson’s disease in the MMRRC repository.

March is National Kidney Month

This March during National Kidney Month, he NIH-NIDDK is focusing on raising that Chronic Kidney Disease is a serious condition affecting more than 30 million adults in the United States, yet people in the early stages may not have symptoms. Many people don’t find out they have kidney disease until their kidneys are permanently damaged. To learn more about Kidney Disease, visit the NIH-NIDDK’s official website:

https://www.niddk.nih.gov/health-information/kidney-disease

Popular MMRRC Kidney Disease Month Strains:

Contact us if you need assistance with learning more about the more than 320 strains related to Kidney Disease available in the MMRRC repository.

MMRRC Announces Availability of KOMP Repository Mice & ES Cells

The Mutant Mouse Resource and Research Center (MMRRC), the official National Institute of Health (NIH) repository of mouse models, is pleased to announce the availability of genetically-altered mice and embryonic stem (ES) cells made as part of the NIH Knockout Mouse Project (KOMP) and previously maintained in the KOMP Repository. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community.

These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. The MMRRC at UC Davis is the largest of four regional archive and distribution centers in the NIH consortium. The MMRRC functions as a single repository resource and is comprised of an Informatics, Coordination and Service Center (ICSC) and three additional regional distribution facilities which include: The Jackson Laboratory, University of Missouri, and University of North Carolina, Chapel Hill. The newly available KOMP Repository mice (4,175 unique lines) & ES cell lines (14,013 unique mutant lines and 7 parental lines) can be accessed by visiting the MMRRC website (www.mmrrc.org) and typing in "KOMP Repository" in the search function, or by using the advanced search function and indicating “Major Collection = KOMP", and then searching by gene of interest, which will allow filtering for ES cells or mice.

The MMRRC was created in 1999, and is supported through the NIH, Office of Infrastructure and Research Programs (ORIP), as the nation’s premier mouse archive and distribution repository. Since that time, the MMRRC has earned an international reputation for the management, cryopreservation, and distribution of scientifically valuable, genetically engineered mouse strains and mouse ES cells. In partnership with researchers around the globe, the MMRRC continues to expand its holdings of mouse models. Today, with more than 59,000 available models, the MMRRC serves as a valuable resource to drive research discoveries for human disease.

February is American Heart Month

This February during American Heart Month, the NIH is encouraging people to take charge of their health and start new, heart-healthy behavior that can help reduce their risk of heart disease and stroke. For more information, visit the NIH’s official website.

https://www.nhlbi.nih.gov/health/educational/hearttruth/lower-risk/what-is-heart-disease.htm

Popular MMRRC Heart Month Strains:

January is National Birth Defects Prevention Month

This month seeks to promote health and awareness of birth defects. At the MMRRC, we understand that data sharing is essential to speed translation of research results into knowledge, therapies, and procedures to improve human health. The MMRRC is committed to sharing data and offers several strains and models to advance research in structural birth defects and foster discovery of shared genetic pathways between disorders.

https://www.nichd.nih.gov/about/overview/directors_corner/prev_updates/010715-birth-defects

Popular research models available in the MMRRC include:

down syndrome
neural tube defects
chromosome aberrations
spinal bifida
cystic fibrosis
cleft palate
fragile X

MMRRC Education & Outreach Booth Conference Wrap Up

The MMRRC education booth is back from two exciting end of the year conferences in San Diego: ASHG and SfN. Both conferences boasted strong attendance rates, with ASHG claiming their highest attendee count to date. There were many great poster sessions showcasing the latest research efforts involving the use of mouse models. We had the pleasure of meeting many new investigators and students and learning about their research efforts involving the use of mice. We were also excited to provide information about role that the MMRRC plays with archiving and distribution of mouse models, and the importance of rigor and reproducibility. It’s always great to see that our outreach and education efforts can have an impact on increasing awareness of the MMRRC.

#mousemodels #mouseresearch #rigorandreproducibility #NIHORIP #mouseresearchstudies #MMRRC #MMRRCMice #ASHG #ASHG2018 #ASHG18 #SFN2018 #SfN18

November is Diabetes Awareness Month

This November during Diabetes Awareness Month, the NIH is encouraging people to gain understanding and offer support to those dealing with the challenges of diabetes. For more information on Diabetes, visit the NIH’s official website.

https://www.nih.gov/about-nih/what-we-do/nih-turning-discovery-into-health/diabetes

Popular MMRRC Diabetes Awareness Month Strains:

October is Breast Cancer Awareness Month

This October during Breast Cancer Awareness Month, the NIH is joining efforts across the U.S. to raise awareness, share information, and highlight research to help fight the disease. For more information on Breast Cancer, visit the NIH’s official website.

https://www.cancer.gov/

Popular MMRRC Breast Cancer Awareness Month Strains

September is Prostate Cancer Awareness Month

This September during Prostate Cancer Awareness Month, the NIH is working to provide easily accessible prostate health screenings and to educate the public about risk factors of prostate related diseases. For more information on Prostate Cancer, visit the NIH’s official website.

https://report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=60

Popular MMRRC Prostate Cancer Awareness Month Strains

Contact us if you need assistance with learning more about strains related to Spinal Muscular Atrophy in the MMRRC repository.

August is Spinal Muscular Atrophy Awareness Month

https://www.ninds.nih.gov/Disorders/All-Disorders/Spinal-Muscular-Atrophy-Information-Page

Popular MMRRC Spinal Muscular Atrophy Awareness Month Strains

Contact us if you need assistance with learning more about strains related to Spinal Muscular Atrophy in the MMRRC repository.

July 28th is World Hepatitis Day

On July 28th, during World Hepatitis Day, the NIH aspires to join people together and raise the profile of viral hepatitis among the public, the world’s media, and on the global health agenda. For more information on Hepatitis, visit the NIH’s official website.

https://www.niaid.nih.gov/diseases-conditions/hepatitis

Popular MMRRC World Hepatitis Day Strains

June is Alzheimer’s Awareness Month

This June during Alzheimer’s Awareness Month, the NIH is encouraging people to learn more about Alzheimer’s, share their stories, and take action to fight the disease. For more information on Alzheimer’s disease, visit the NIH’s official website.

https://www.nia.nih.gov/health/alzheimers

Popular MMRRC Alzheimer’s Awareness Month Strains

May is Cystic Fibrosis Awareness Month

https://ghr.nlm.nih.gov/condition/cystic-fibrosis

Popular MMRRC Cystic Fibrosis Awareness Month Strains

New MMRRC Submission Form Coming Soon!

The MMRRC is excited to announce the upcoming release of our newly redesigned submission form set for debut on Wednesday, May 2nd 2018.

Along with user-friendly navigation the form has been significantly reduced to only include the bare minimum criteria needed for strain acceptance. The new design allows users to navigate through the submission form easily and effectively with informative tool-tips to help explain and clarify questions.

Our new shorter form will reduce completion time significantly and make multiple submissions a much simpler process. We anticipate a smooth transition over and look forward to hearing your feedback!

April is Parkinson’s Awareness Month

https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page

Popular MMRRC Parkinson’s Awareness Month Strains

B6.129-Dnajc6^tm1Legr/Mmjax

Contact us if you need assistance with learning more about strains related to Parkinson’s disease in the MMRRC repository.

March is Brain Injury Awareness Month

This March during Brain Injury Awareness Month, the NIH is conducting a campaign that is aimed at educating the general public about the incidence of brain injuries and the needs of people with brain injuries. For more information on traumatic brain injuries, visit the NIH’s official website.

https://www.ninds.nih.gov/Disorders/All-Disorders/Traumatic-Brain-Injury-Information-Page

Popular MMRRC Brain Injury Awareness Month Strains:

February is American Heart Month

https://www.nhlbi.nih.gov/health/educational/hearttruth/lower-risk/what-is-heart-disease.htm.

Popular MMRRC Heart Month Strains:

MMRRC to attend ASHG in Orlando

Representatives from the MMRRC will be attending American Society of Human Genetics 2017 October 17 – 21 in Orlando FL. Please be sure to stop by our education and outreach booth and learn more about how the MMRRC can help you with your mouse related research needs.

http://www.ashg.org/2017meeting/

MMRRC to attend Society for Neuroscience in Washington DC

Representatives from the MMRRC will be attending Society for Neuroscience 2017 November 11 – 15 in Washington, DC. Please be sure to stop by our education and outreach booth and learn more about how the MMRRC can help you with your mouse related research needs.

https://www.sfn.org/annual-meeting/neuroscience-2017

MMRRC attending Experimental Biology 2017 in Chicago

Representatives from the MMRRC will be attending Experimental Biology 2017 April 22 – 26 in Chicago, IL. Please be sure to stop by booth #1412 and learn more about how the MMRRC can help you with your mouse related research needs.

http://experimentalbiology.org/2017/Home.aspx

Are you interested in a particular gene?

The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterizing them through standardized, quality-controlled phenotyping tests.

IMPC Flyer

KOMP 2 Phase 2 Mouse Lines Available Through The MMRRC

Since 2006, researchers around the world have been working together to generate a targeted knockout mutation for every gene in the mouse genome. The US component of this effort, The Knockout Mouse Project (KOMP), has been providing critical tools for understanding gene function and the genetic causes of human diseases.

In 2016, the National Institutes of Health funded the next phase in the KOMP project called KOMP2 Phase 2 with the objective to produce and phenotype more than 3000 new knockout mouse lines on a C57BL6/N genetic background. Here at the MMRRC, we are pleased to announce that these KOMP2 Phase2 mouse lines will all be made available from the MMRRC repositories. New mouse lines will be added monthly and full phenotyping data will be available.

MMRRC Repository Expands Available Mouse Mutations

Genetically engineered mice serve as valuable models of human disease, contributing to major medical breakthroughs. Often, biomedical researchers must develop unique genetically modified strains of mice for experimentation, a costly and time-consuming process. Now, more researchers in fields from immunology to cancer may be able to save time and money by acquiring genetic material from a repository of previously engineered strains.

https://www.niaid.nih.gov/news-events/niaid-supported-research-expands-number-publicly-available-mouse-mutations

MMRRC will be attending ASHG 2016 in Vancouver, BC

Representatives from the MMRRC will be attending The Allied Genetics Conference July 13 – 17 in Orlando FL. Please be sure to stop by our booth and learn more about how the MMRRC can help you with your mouse related research needs. http://www.genetics2016.org

MMRRC will be attending SfN 2016 in San Diego, CA

Representatives from the MMRRC will be attending Society for Neuroscience 2016 November 13 –16 in San Diego, CA. Please be sure to stop by booth #4322 and learn more about how the MMRRC can help you with your mouse related research needs. https://www.sfn.org/annual-meeting/neuroscience-2016

MMRRC attending Experimental Biology 2016 in San Diego

Representatives from the MMRRC will be attending Experimental Biology 2016 April 2 – 6 in San Diego CA. Please be sure to stop by booth #1104 and learn more about how the MMRRC can help you with your mouse related research needs. http://experimentalbiology.org/2016/Home.aspx

MMRRC attending The Allied Genetics Conference 2016 in Orlando

Representatives from the MMRRC will be attending American Society for Human Genetics 2016 October 18 – 22 in Vancouver, BC. Please be sure to stop by booth #422B and learn more about how the MMRRC can help you with your mouse related research needs.
http://www.ashg.org/2016meeting/

The Value of Biological Repositories

Read the recently published article in Nature about how the MMRRC repository provides scientific value and utility through curation, preservation, genetic quality control, and protection from pathogens. Learn about the efforts that the MMRRC takes to help researchers reduce model redundancy and improve reproducibility of studies. http://www.nature.com/news/reproducibility-use-mouse-biobanks-or-lose-them-1.17707

MMRRC attending the 66th Annual AALAS National Meeting

Representatives from the MMRRC will be attending the 66th Annual AALAS National Meeting November 1-5, 2015 Phoenix, AZ. Please be sure to stop by booth #215 and learn more about how the MMRRC can help you with your mouse related research needs. https://www.aalas.org/national-meeting#.VRrfaE10y70

MMRRC attending ASCB 2014 in Philadelphia

Representatives of the Mutant Mouse Regional Resource Center will be attending the American Society of Cell Biology Meeting in Philadelphia December 6-10. Please come by booth #916 and let us help you with your mouse research needs.

dkNET Releases Version 1.2

The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). The dkNET portal contains information about research resources such as antibodies, vectors and mouse strains, data, protocols, and literature.

MMRRC updated order form

The MMRRC is pleased to officially announce the release of our newly redesigned order process! Along with user-friendly navigation and the new "Favorites" feature, the order form has been updated with the latest information and a fresh new look. The new design allows users to navigate through the order process easily and effectively with alerts for missed questions, in-line hints, and the ability to alter contact information within the form. The new Favorites feature allows users to save and organize their favorite products and even allows them to send their favorites list to their registered email account for later reference.

Look for the MMRRC booth at the following shows. Stop by the booth and learn how to find or donate your mouse model.

April 26 – 30
Experimental Biology
Booth 1439
San Diego, CA, San Diego Convention Center
http://experimentalbiology.org/2014/Home.aspx

October 18 - 22
American Society Human Genetics
Booth TBD
San Diego, CA, San Diego Convention Center
http://www.ashg.org/2014meeting

November 15 – 19
Neuroscience
Booth TBD
Washington, DC, Walter E. Washington Convention Center
http://www.sfn.org/annual-meeting/neuroscience-2014

December 6 - 10
American Society Cell Biology
Booth TBD
Pennsylvania, PA, Pennsylvania Convention Center
http://www.ascb.org/meetings-home

MMRRC at the 2013 American Society for Cell Biology meeting in New Orleans

The Mutant Mouse Regional Resource Center (MMRRC) will be attending the 2013 American Society for Cell Biology Meeting December 14 through 18 in New Orleans. The MMRRC has been able to map 900 MeSH terms from attendee publications to mouse models within our repositories. If you are attending the meeting, then please consider visiting our booth and speaking directly with one of our knowledgeable customer service staff members.

MMRRC now searchable by major MeSH terms

The Mutant Mouse Regional Resource Center (MMRRC) repository simple and advanced search methods now include the ability to search by associated Major Medical Subject Heading (MeSH) terms. MeSH is the National Library of Medicine\'s controlled vocabulary thesaurus. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity. Major MeSH terms are defined by authors of primary research articles as having the most relevance to the research represented by the article.

MMRRC at the Society of Neuroscience Meeting in San Diego

The Mutant Mouse Regional Resource Center (MMRRC) will be attending the Society of Neuroscience Meeting in San Diego November 9-13 (booth 3831). Among the thousands of model systems within the MMRRC repository, the MMRRC has 440 neuroscience models in 700 major Medical Subject Heading (MeSH) categories. If you are attending the meeting, then please consider visiting our booth (#3831) and speaking directly with one of our knowledgeable customer service staff members.

IMPC Survey of the Mouse User Community

The International Mouse Phenotyping Consortium is conducting a survey with the goal of exploring ways to ensure that researchers utilize high-impact mouse-model resources. The on line survey is available here.

Reversal of Behavioral Deficits and Synaptic Dysfunction in Mice Overexpressing Neuregulin 1

When expressed in mice, high levels of Neuregulin 1 (Nrg1) lead to behavioral deficits and hypofunction of glutamatergic and GABAergic pathways similar to that found in human patients with schizophrenia. Don-Yin Min, et al. found that these effects are diminished when Nrg1 levels are returned to normal.

The MMRRC has related mouse models.

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

Evidence that that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM.
Full publiceation here.

The MMRRC has a related ES cell line.

Gene found that regenerates heart tissue

Researchers at UT Southwestern Medical Center have identified a specific gene, Meis1 that regulates the heart’s ability to regenerate after injuries. The original article can be found in Nature.

The MMRRC has a GENSAT mouse containing multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the Meis1 coding sequence of the targeted gene.

MMRRC Resuscitation Success Rate

In 2012, the MMRRC was able to successfully deliver 246 out of 247 resuscitation orders. Please consider our services to best meet your research needs.

Scientists Make Mouse Model of Human Cancer

Scientists Make Mouse Model of Human Cancer, Demonstrate Cure
UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer. Blocking the activity of a receptor molecule named CXCR4 inhibited tumor development of malignant peripheral nerve sheath tumors (MPNSTs).

STOCK Tg(Cxcr4-EGFP)CD73Gsat/Mmucd is available from the MMRRC and contains multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the coding sequence of the targeted gene.

MMRRC iPod Raffle Winner: Caius G. Radu, M.D. - UCLA

In an effort to determine MMRRC's contribution to biomedical research, we reached out to all our previous customers and asked for additional information on previous orders. Customers who filled out the raffle form with valid NIH Grant entries and/or Pubmed publication IDs were entered into a raffle with a chance to win a new iPod. The raffle winner was selected today. Congratulations to Dr. Caius G. Radu from University of California, Los Angeles for winning the iPod. We would like to thank all those who participated in this raffle and provided valuable information about their past purchases from MMRRC. We appreciate their time and effort.

Transmission of tangles in Alzheimers mice provides more authentic model of tau pathology

Brain diseases associated with the misformed protein tau, including Alzheimers disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological tau filaments. article Mapt at MMRRC

Terry Magnuson elected to IOM 2012.

Our very own Terry R. Magnuson, Ph.D., Sarah Graham Kenan Professor and chair, department of genetics, and vice dean for research, School of Medicine, University of North Carolina, Chapel Hill, and Project Director for the MMRRC at North Carolina-Chapel Hill, was just elected to the Institute of Medicine of the National Academies.

New MMRRC released!

Welcome to the newly revised MMRRC website! The goal of this revision is to modernize the look and feel of MMRRC's web presence. We hope the new simplified search feature will make finding the products you are looking for easier. For any questions/problems you have regarding this release, please email us at service@mmrrc.org, or use the Feedback function to the right side of the page.

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Customer Service:
service@mmrrc.org

Web Support:
support@mmrrc.org

North America:
800-910-2291

International:
530-757-5710

Follow @mmrrc

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Welcome to the Mutant Mouse Resource & Research Centers (MMRRC) Website

The MMRRC is the nation’s premier national public repository system for mutant mice. Funded by the NIH continuously since 1999, the MMRRC archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by the biomedical research community. The MMRRC consists of a national network of breeding and distribution repositories and an Informatics Coordination and Service Center located at 4 major academic centers across the nation. The MMRRC is committed to upholding the highest standards of experimental design and quality control to optimize the reproducibility of research studies using mutant mice. The MMRRC is supported by the Office of Research Infrastructure Programs (ORIP) in the Office of the Director at NIH. More than 50,000 mutant alleles are maintained as live mice, cryopreserved germplasm, and/or mutant ES cells. Live mice are supplied from a production colony, from a colony recovered from cryopreservation, or via micro-injection of ES cells. An MMRRC facility may offer cryopreserved material for resuscitation at the recipient scientist's institution.

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About MMRRC

Welcome to the Mutant Mouse Resource & Research Centers (MMRRC) Website