Strain Name:
Stock Number:
Citation ID:

Gene Information

Name: whey acidic protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Transgenic
NCBI: 22373
Homologene: 137242
Name: tumor susceptibility gene 101
Synonyms: CC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Transgenic
NCBI: 22088
Homologene: 4584
Name: transgene insertion 4389, Kay-Uwe Wagner
Type: Transgene
Species: Mus musculus (mouse)
Chromosome: unknown
Alteration at locus: Transgenic
Genotype Determination
Homozygous: Same as wild-type

Hemizygous: Same as wild-type, sopradic mammary cancer very late in life in a subset of animals.
MeSH Terms
  • Animals
  • Breast Neoplasms/genetics
  • Breast Neoplasms/metabolism
  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins/biosynthesis
  • DNA-Binding Proteins/physiology
  • Endosomal Sorting Complexes Required for Transport
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MAP Kinase Signaling System
  • Mammary Neoplasms, Animal/genetics
  • Mammary Neoplasms, Animal/metabolism
  • Mammary Neoplasms, Experimental/metabolism
  • Mice
  • Mice, Transgenic
  • Neoplasm Invasiveness
  • Signal Transduction
  • Transcription Factors/biosynthesis
  • Transcription Factors/physiology
  • Up-Regulation
Suggested Control Mice

Wildtype littermates

  • Cancer
  • Cell Biology
Kay-Uwe Wagner, Ph.D., University of Nebraska Medical Center
Primary Reference
Oh KB, Stanton MJ, West WW, Todd GL, Wagner KU. Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene. 2007 Aug 30;26(40):5950-9. Epub 2007 Mar 19. (Medline PMID: 17369844)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Onco-Mouse Patents. Canada: CA1341442 expires Oct. 7, 2020. US patents: 5,925,803 expires July 20, 2016 5,807,571 expired Feb. 11, 2009 4,736,866 expired April 12, 2005

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
030909-MU-SPERM Cryo-preserved spermatozoa $437.00 / Non-Profit Aliquot Approximate quantity2
030909-MU-RESUS Litter recovered from cryo-archive $2,697.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.