The Mutant Mouse Resource & Research Centers (MMRRC), https://mmrrc.org is the NIH’s premier national consortium that provides the worldwide biomedical research community with access to more than 30,000 strains of mutant mice and ES cells. With one of the largest nonprofit repositories of mouse models in the world, the MMRRC distributes and archives models to advance the biomedical research efforts of the scientific research community. Each month through partnerships with researchers around the world, the MMRRC enhances critical research with a continuously expanding catalog of mouse models of human disease.
The MMRRC is your one stop resource for unique and popular research related mouse models offering specific gene deletions, insertions, modifications and repressions, and phenotypes.
The ACD Working Group was charged with assessing and making recommendations to enhance the rigor, transparency, and translatability in animal research by improving experimental design, optimizing translational validity, enhancing training, and increasing the transparency of research studies involving animal models.
Over the past several years, there has been a growing awareness of the need for rigorously designed published research studies that are both transparent and reproducible. In response to this need, the National Institutes of Health (NIH) launched on January 25, 2016 a formal initiative aimed at improving research reproducibility through an emphasis on scientific rigor and transparency.MMRRC’s Commitment to Optimizing Reproducibility
The MMRRC is committed to upholding the highest standards of experimental design and quality control to optimize the reproducibility of research studies using mutant mice. For example, understanding, documenting, and accurately reporting the genetic backgrounds of mouse models used in research is essential for recreating an experimental study and achieving reproducible results.
If research is to be reliable and reproducible, specific quality control and assurance testing need to be in place. This is why mouse models available from the MMRRC repository are annotated with well documented genetic backgrounds. Furthermore, because of our commitment to maintaining specific-pathogen-free vivaria and quality control measures, investigators can rely on mice obtained from the MMRRC to generate robust and reproducible results.What is Scientific Rigor & Transparency?
Specifically, the NIH defines scientific rigor as “the strict application of scientific method to ensure unbiased and well-controlled experimental design, methodology, analysis, interpretation, and reporting of results.” Scientific rigor also includes transparency in reporting full experimental details so that others may reproduce experimental procedures and extend the findings.The MMRRC helps you address the NIH’s new focus areas of rigor and transparency:
In addition to a commitment to reproducibility, the MMRRC provides training opportunities in research using genetically-altered mice. We believe in fostering the development of outstanding scientists and to help them expand their potential to make significant contributions in their field of research. The MMRRC has the ability to provide training through guest lectures, webinars, seminars, and workshops in areas including nomenclature and biological variables to name just a few.
If you are interested in learning more about educational training and career development please contact email@example.com directly to find out how MMRRC can assist you with your educational needs.Authentication of Mice Using the Strain Detail Sheet
At the MMRRC we document, verify and authenticate each detail on our archived strains. Investigators wishing to publicize information about their strains on their own web site may want to include a link to the MMRRC's Strain Detail Sheet (SDS) for their specific strain. This would save visiting investigators from having to locate it themselves. On the SDS page, investigators will find information provided by the donating investigator, additional information curated by the MMRRC, relevant genotyping protocols and specifics about husbandry, care, and management. In addition, users can find information on availability and prices, including fees for shipping and handling, for available product items. The online request form can be accessed directly from a strain’s SDS page.How to Acknowledge MMRRC Mice
Your research is important to the MMRRC and the greater research community. By obtaining mice from the MMRRC, we respectfully request that you acknowledge the MMRRC (Mutant Mouse Resource and Research Center) in your research publications. Suggested text is to include in publications, grants, and presentations is provided below. As an NIH-supported, not-for-profit resource center, your acknowledgement is vital to inform others of our commitment to rigor, transparency and reproducibility. We ask that investigators provide via email (firstname.lastname@example.org) copies of any published papers using products obtained from the MMRRC.
The significance of understanding and documenting the genetic backgrounds of mouse models used in research is of utmost importance for the Mutant Mouse Resource & Research Center (MMRRC). The MMRRC understands that if research is to be reliable and reproducible, specific quality control measures and testing need to be in place. Models available from the MMRRC repository have well documented defined, stable genetic backgrounds. This strong genetic integrity coupled with quality control measures allows investigators to generate robust and reproducible results for future comparison.
In help ensure that MMRRC strains are held to the highest standards to optimize reproducibility of studies, all submitted strains are thoroughly reviewed and documented and include additional quality control measures that involve: