When expressed in mice, high levels of Neuregulin 1 (Nrg1) lead to behavioral deficits and hypofunction of glutamatergic and GABAergic pathways similar to that found in human patients with schizophrenia. Don-Yin Min, et al. found that these effects are diminished when Nrg1 levels are returned to normal.

The MMRRC has related mouse models.