Strain Name:
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Gene Information

Allele Symbol: Sod1tm1Cje (Mus musculus (mouse))
Name: superoxide dismutase 1, soluble; targeted mutation 1, Charles J Epstein
Synonyms: SOD1<->
Chromosome: 16
Alteration at locus: Knockout
Monarch Initiative (Disease and Phenotype Associations): MGI:2680903
Gene Symbol: Sod1 (Mus musculus (mouse))
Name: superoxide dismutase 1, soluble
Synonyms: B430204E11Rik, Ipo-1, Cu(2+)-Zn2+ superoxide dismutase, Cu/Zn-SOD, Sod-1, CuZnSOD, SODC, Ipo1
Chromosome: 16
Alteration at locus: Knockout
Monarch Initiative (Disease and Phenotype Associations): MGI:98351
Genetic Alterations
The 3rd and 4th exons of Sod1 were replaced with CITE-neo.
Genotype Determination
ES Cell Line
CB1-4 derived from C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
The heterozygous mutants have no overt phenotype. The homozygous mutants develop hepatocellular carcinoma by 20 months of age and have an average lifespan of 20 months.
Mammalian Phenotype Terms
Allelic Composition: Sod1tm1Cje/Sod1tm1Cje (Genetic Background: involves: C57BL/6J * CD-1 )

Strain Development
See primary reference.
Suggested Control Mice
  • Wildtype littermates
  • C57BL/6
  • Apoptosis
  • Cancer
  • Cell Biology
  • Diabetes/Obesity
  • Models for Human Disease
Ting-Ting Huang, Ph.D., Stanford University
Primary Reference
  • Huang TT, Yasunami M, Carlson EJ, Gillespie AM, Reaume AG, Hoffman EK, Chan PH, Scott RW, Epstein CJ. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32. (Medline PMID: 9264557)
  • Kondo T, Reaume AG, Huang TT, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ, Chan PH. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci. 1997 Jun 1;17(11):4180-9. (Medline PMID: 9151735)
  • Kondo T, Reaume AG, Huang TT, Murakami K, Carlson E, Chen S, Scott RW, Epstein CJ, Chan PH. Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice. Acta Neurochir Suppl. 1997;70:62-4. (Medline PMID: 9416279)

Colony and Husbandry Informationon

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
MMRRC Breeding System
Non inbred
Breeding Scheme(s)
Heterozgyous female x C57BL/6 male
Overall Breeding Performance
Average litter size
6 - 8
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
000203-MU-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity3 : 20-40 embryos / aliquot
000203-MU-SPERM Cryo-preserved spermatozoa $437.00 / Non-Profit Aliquot Approximate quantity2
000203-MU-RESUS Litter recovered from cryo-archive $2,016.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.