Phenotype
Homozygous: low birth weight, high mortality at birth, fertility problems
Heterozygous: none
Cre-excised Phenotype: undetermined
Mammalian Phenotype Terms


Allelic Composition: Dnajc6
tm1Legr/Dnajc6
tm1Legr (Genetic Background: B6.129-Dnajc6
tm1Legr )
- mortality/aging
- reproductive system
- nervous system
- growth/size/body


Allelic Composition: Dnajc6
tm1Legr/Dnajc6
+ (Genetic Background: B6.129-Dnajc6
tm1Legr )
- mortality/aging
- growth/size/body
MeSH Terms
- Animals
- Auxilins/genetics
- Auxilins/physiology
- Clathrin/metabolism
- Endocytosis
- Female
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nerve Endings/metabolism
- Protein-Serine-Threonine Kinases/metabolism
- Synapses/metabolism
- Up-Regulation
- Adolescent
- Auxilins/metabolism
- Base Sequence
- DNA Mutational Analysis/methods
- Family Health
- HSP40 Heat-Shock Proteins/genetics
- HSP40 Heat-Shock Proteins/metabolism
- Humans
- Male
- Molecular Chaperones/genetics
- Molecular Chaperones/metabolism
- Mutation
- Neurons/metabolism
- Parkinsonian Disorders/genetics
- Pedigree
Strain Development
Gene targeted GSI 129/SV embryonic stem cells injected into C57BL/6 blastocysts to generate chimeras. Chimeras crossed to C57BL/6 mice to generate heterozygotes, the linearized targeting construct was then introduced into the embryonic stem cell line GSI 129/SV. The transfectants were rst selected by a G418 resistance cassette, followed by Southern blot analysis to obtain the positive clones (Fig. S1B). Genotyping of the offspring was performed by Southern blot analysis or PCR using DNA from tail snips. For the experiments reported in the study, we backcrossed the S129 heterozygote mutant mice with wild-type C57BL/6 mice to completely transfer the genotype from the S129 mice strain to the C57BL/6 strain. After eight backcrossings, heterozygote mice were mated to obtain homozygote auxilin knockout mice.
Suggested Control Mice
Wild-type littermates