Strain Detail Sheet
Homozygous: Mice show altered electrical communication in the retina, more susceptable to lung injury.
Heterozygous: Not characterized.
Allelic Composition: Kcnk2tm1Lex/Kcnk2tm1Lex (Genetic Background: involves: 129 * C57BL/6 )- cardiovascular system
- cardiovascular system phenotype [MP:0005385] [PMID:20357027] (J:210951)
- Action Potentials
- Animals
- Aorta/metabolism
- Arachidonic Acid/metabolism
- Basilar Artery/drug effects
- Basilar Artery/metabolism
- Cardiovascular
- Developmental Biology
- Internal/Organ
- Models for Human Disease
- Depression
- Brain Injury (neuroprotection)
- Neurobiology
- Sensorineural
Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ and Bryan RM, Jr. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R461-9. doi: 10.1152/ajpregu.00057.2010. Epub 2010 Mar 31. (Medline PMID:20357027)
Namiranian K, Brink CD, Goodman JC, Robertson CS and Bryan RM, Jr. Traumatic brain injury in mice lacking the K channel, TREK-1. J Cereb Blood Flow Metab. 2011 Mar;31(3):e1-6. doi: 10.1038/jcbfm.2010.223. Epub 2010 Dec 15. (Medline PMID:21157470)
Ford KJ, Arroyo D, Kay J, Lloyd EE, Bryan RM, Jr., Sanes J and Feller MB. A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. J Neurophysiol. 2013 May;109(9):2250-9. doi: 10.1152/jn.01085.2012. Epub 2013 Feb 6. (Medline PMID:23390312)
Colony Surveillance Program and Current Health Reports
Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu .Wild-type (C57BL/6) female x Heterozygous male or reciprocal mating
| Viability and Fertility: | Female | Male | Comments |
|---|---|---|---|
| Homozygotes are viable: | Yes | Yes | |
| Homozygotes are fertile: | Yes | Yes | |
| Heterozygotes are fertile: | Yes | Yes | |
| Age Reproductive Decline: | 12 months | 12 months |
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
Distribution of this strain requires execution of the Lexicon Simple Letter Agreement. A link to this form will be provided via email when an order is submitted; the PDF form should be downloaded or the email forwarded to the appropriate institutional representative for completion following directions in the document.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
| MMRRC Item # | Description | Distribution Fee / Unit (US $) *Shipping & Handling not included* |
Units | Notes |
|---|---|---|---|---|
| 036938-UCD-EMBRYO | Cryo-preserved embryos | $1,038.00 / Non-Profit | Aliquot | Approximate quantity2 : 20-40 embryos / aliquot |
| 036938-UCD-SPERM | Cryo-preserved spermatozoa | $546.25 / Non-Profit | Aliquot | Approximate quantity3 |
| 036938-UCD-RESUS | Litter recovered from cryo-archive | $3,033.00 / Non-Profit | Litter | Recovered litter4; additional fees for any special requests. |
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.