Strain Name:
Stock Number:
Citation ID:
Other Names:
Xanthine Dehydrogenase knockout mouse, B6.129X1-Xdhtm1Fink/Mmcd

Gene Information

Allele Symbol: Xdhtm1Fink [MGI:3611749] (Mus musculus (mouse))
Name: xanthine dehydrogenase; targeted mutation 1, Toren Finkel
Synonyms: Xor-
Chromosome: 17
Alteration at locus: Targeted Mutation
Gene Symbol: Xdh [MGI:98973] (Mus musculus (mouse))
Name: xanthine dehydrogenase
Synonyms: xanthine oxidase, Xor, Xox1, XO, Xox-1
Chromosome: 17
Alteration at locus: Targeted Mutation
Genetic Alterations
Portions of exon 3 and exon 4 and the entire intron 3 were replaced by a phosphoglycerate kinase/neo cassette in an effort to disrupt the Xanthine Dehydrogenase gene.
Genotype Determination
ES Cell Line
GSI-1 Derived From 129X1/SvJ
Homozygous: The homozygote mice die around 21 days after birth. They show growth retardation starting on day 15 after birth and probably die of renal dysplasia.

Heterozygous: Normal
Mammalian Phenotype Terms
Allelic Composition: Xdhtm1Fink/Xdhtm1Fink (Genetic Background: involves: 129X1/SvJ * C57BL/6J )

MeSH Terms
  • Animals
  • Blood Urea Nitrogen
  • Cyclooxygenase 2
  • Disease Progression
  • Enzyme Induction
  • Female
  • Genes, Lethal
  • Genetic Heterogeneity
  • Hypertension/blood
  • Hypertension/enzymology
  • Inflammation
  • Kidney/enzymology
  • Kidney/pathology
  • Kidney Diseases/blood
  • Kidney Diseases/enzymology
  • Kidney Diseases/genetics
  • Kidney Diseases/pathology
  • Male
  • Mice
  • Mice, Knockout
  • NIH 3T3 Cells/enzymology
  • Phenotype
  • Prostaglandin-Endoperoxide Synthases/biosynthesis
  • Prostaglandin-Endoperoxide Synthases/genetics
  • Uric Acid/pharmacology
  • Xanthine Oxidase/deficiency
  • Xanthine Oxidase/genetics
  • Xanthine Oxidase/physiology
Strain Development
Donor received this mouse as a chimera of 129/C57BL/6J and over time the strain has been back crossed to a C57BL/6J background.
Suggested Control Mice
Wild-type littermates
  • Cardiovascular
  • Developmental Biology
  • Diabetes/Obesity
  • Immunology and Inflammation
  • Internal/Organ
  • Metabolism
  • Models for Human Disease
  • Research Tools
Toren Finkel, M.D., Ph.D., National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health
Primary Reference
Ohtsubo T, Rovira II, Starost MF, Liu C, Finkel T. Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. Circ Res. 2004 Nov 26;95(11):1118-24. Epub 2004 Nov 4. (Medline PMID: 15528468)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
Bred to Homozygosity

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
014110-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / $1,549.67
Non-Profit / For-Profit
Aliquot Approximate quantity3 : 20-40 embryos / aliquot
014110-UCD-SPERM Cryo-preserved spermatozoa $546.25 / $871.90
Non-Profit / For-Profit
Aliquot Approximate quantity2
014110-UCD-RESUS Litter recovered from cryo-archive $3,033.00 / $6,017.01
Non-Profit / For-Profit
Litter Recovered litter1; additional fees for any special requests.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.