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Strain Detail Sheet

Published: 01/08/2019
Revised: 01/08/2024

Strain Name:
C57BL/6N-Tsttm1.1(KOMP)Vlcg/MbpMmucd
Stock Number:
050239-UCD
Citation ID:
RRID:MMRRC_050239-UCD
Other Names:
Tst_AE4, VG13928, ET8409
Major Collection:
KOMP

Strain Information

Gene Details

Tsttm1.1(KOMP)Vlcg
Name: thiosulfate sulfurtransferase, mitochondrial; targeted mutation 1.1, Velocigene
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Targeted Mutation, Deletion
Tst
Name: thiosulfate sulfurtransferase, mitochondrial
Synonyms: Rhodanese
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22117
VEGA: 15
Homologene: 37759

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations

CREed Deletion

Further details at: http://velocigene.com/komp/detail/13928

KOMP Targeting Strategies

Genotype Determination
Genotyping Protocol
ES Cell Line
VGB6 derived from C57BL/6NTac

Strain Description

Phenotype
Phenotyping data may be available at mousephenotype.org.
Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • endocrine/exocrine glands
    • abnormal seminal vesicle morphology []
  • reproductive system
    • abnormal seminal vesicle morphology []
    • abnormal epididymis morphology []
MeSH Terms
  • Animals
  • Animals, Genetically Modified/genetics
  • Animals, Genetically Modified/metabolism
  • Chromosomes, Artificial, Bacterial/genetics
  • Chromosomes, Artificial, Bacterial/metabolism
  • Electroporation/methods
  • Gene Expression Profiling/methods
  • Gene Targeting/methods
  • Genetic Engineering/methods
  • Genome
  • Mice/genetics
  • Mutagenesis, Insertional/methods
  • Mutagenesis, Site-Directed
  • Quality Control
  • Recombinant Proteins/genetics
  • Recombinant Proteins/metabolism
  • Stem Cells/metabolism
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Submitter
The KOMP Repository, University of California, Davis; Originating from Kent Lloyd, UC Davis Mouse Biology Program
Primary Reference
Valenzuela, D. M., Murphy, A. J., Frendewey, D., Gale, N. W., Economides, A. N., Auerbach, W., Poueymirou, W. T., Adams, N. C., Rojas, J., Yasenchak, J., et al. (2003). High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21, 652-659. (PMID: 12730667)
Strain Development
ES cell clone 13928A-E4 was injected into morulae or blastocysts. Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1 (Deletion) animals were generated. Heterozygous tm1 mice were then bred to a ubiquitous Cre deleter mouse line for recombination of the LoxP sites to generate the tm1.1 (CREed Deletion) allele mice. The archived germplasm does not contain the Cre transgene. The MMRRC will use C57BL/6N females for cryo-recovery.

Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain's tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@ucdavis.edu

Appearance

Coat Color
black

Breeding

MMRRC Breeding System
Backcross or Sib-Mating

Order Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

Distribution of this strain requires submission of the KOMP MTA. The MTA should be signed by an authorized official from your institution, generally this is someone in your Technology Transfer or Intellectual Property offices. A link to this form will be provided via email when an order is submitted; the PDF form should be downloaded or the email forwarded to the appropriate institutional representative for completion following directions in the document.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.