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Strain Detail Sheet

Published: 07/19/2022
Revised: 07/23/2022

Strain Name:
CC083/UncMmnc
Stock Number:
066495-UNC
Citation ID:
RRID:MMRRC_066495-UNC
Major Collection:
Collaborative Cross

Strain Information

Gene Details

Genetic Alterations

CC083/UncMmnc is a strain from the Collaborative Cross collection of recombinant inbred strains.

Genotype Determination
Collaborative Cross strains are genotyped annually using the MiniMUGA genotyping array to confirm identity based on comparison to the consensus genotypes of the full set of common ancestors alive in 2020-2021. Consensus genotypes for this strain can be found here here. Please contact mmrrc_cc@unc.edu to request additional genotyping for your mice.

Strain Description

MeSH Terms
  • Animals
  • Breeding
  • Community Networks
  • Crosses, Genetic
  • Databases, Genetic
  • Health Resources
  • Health Services Research
  • Humans
  • Mice
  • Mice, Inbred Strains
  • Recombination, Genetic
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Research Applications

  • Models for Human Disease, Research Tools

Strain Origin

Donor
Fernando Pardo-Manuel de Villena, Ph.D., University of North Carolina at Chapel Hill School of Medicine.
Primary Reference
Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD,Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ,Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD,Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J,Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G,Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA,Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, MittlemanG, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH,Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K,Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, QiZ, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K,Shou S, Sillanp MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, TarantinoLM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, WilliamsRW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium. TheCollaborative Cross, a community resource for the genetic analysis of complextraits. Nat Genet. 2004 Nov;36(11):1133-7. (Medline PMID: 15514660)
Additional References

Srivastava A, Morgan AP, Najarian ML, Sarsani VK, Sigmon JS, Shorter JR,Kashfeen A, McMullan RC, Williams LH, Giusti-Rodr guez P, Ferris MT, Sullivan P, Hock P, Miller DR, Bell TA, McMillan L, Churchill GA, de Villena FP. Genomes ofthe Mouse Collaborative Cross. Genetics. 2017 Jun;206(2):537-556. doi:10.1534/genetics.116.198838. (Medline PMID: 28592495)

Collaborative Cross Consortium. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 2012 Feb;190(2):389-401. doi: 10.1534/genetics.111.132639. (Medline PMID: 22345608)

Strain Development
The Collaborative Cross (CC) is a multiparental, recombinant-inbred panel derived from eight laboratory mouse inbred strains. For details on the generation of the mice, see PMID:22345608. For genomic characteristics and other related information see here.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc_health@med.unc.edu

Breeding

MMRRC Breeding System
Random intra-strain mating
Generation
F30+
Overall Breeding Performance
Good

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile:
Age Reproductive Decline: Undetermined Undetermined

Order Information

Availability Level

Live mice available. Please Contact mmrrc_cc@unc.edu to consult on specific experimental needs and place strain orders.

Conditions of Distribution

The Collaborative Cross Conditions of Use can be found here. Mice can be purchased for experimental cohorts or for breeding stock (for internal use only).

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
066495-UNC-SPERM Cryo-preserved spermatozoa $520.00 / $863.00
Non-Profit / For-Profit		 Aliquot Approximate quantity3
066495-UNC-CC-F
066495-UNC-CC-M
Recombinant inbred Female
Recombinant inbred Male
 $226.00 / $226.00
Non-Profit / For-Profit		 Per Mouse
Cryopreserved material may be available upon request, please inquire to mmrrc@med.unc.edu for more information.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.