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Availability & Fees Order this Strain
Homozygous: Homozygous mice exhibit normal anxiety-related behavior an elevated plus maze and light-dark test mice exhibit normal locomotor activity behavioral despair, mice exhibit increased immobility in a forced swim test compared with wild-type mice abnormal motor coordination/ balance, mice swim faster than wild-type mice mice use either one or both front paws sparingly and for steering purposes only unlike wild-type mice mice use their tail for propulsion unlike wild-type mice impaired coordination, mice exhibit a shorter latency to fall from a rotarod than wild-type mice.
Sabino, V., Cottone, P., Parylak, S. L., Steardo, L., Zorrilla, E. P. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res. 2009 Mar 17;198(2):472-6. Epub 2008 Nov 30. (Medline PMID: 19100292).
Ha, Y., Saul, A., Tawfik, A., Williams, C., Bollinger, K., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V., Smith, S. B Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigmaR1). Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7749-60. Print 2011 Sep. (Medline PMID: 21862648).
Colony Surveillance Program and Current Health Reports
Heterozygte breeding, except for the inclusion of 1 immigrant C57BL/6J males every 4 generations to reduce drift.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
Distribution of this strain requires execution of the Lexicon Simple Letter Agreement. A link to this form will be provided via email when an order is submitted; the PDF form should be downloaded or the email forwarded to the appropriate institutional representative for completion following directions in the document.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.