Homozygous: Mice showed showed an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD8+ T cells and CD8+ T cells in CD3+ T cells with a concomitant increase in the CD4+ T cell frequency in CD3+ T cells, all in the peripheral blood. An increase in the CD44+ mean fluorescence intensity on CD8+ T cells was also observed.

Heterozygous: No signficant abnormal phenotype detected.

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

• Immunology and Inflammation

Choi JH, Wang K-W, Zeng M, Murray AR, Beutler B. Record for date. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.