Homozygous: Mice showed an increase in the B:T cell ratio as well as a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells and CD4+ T cells in CD3+ T cells coupled with an increased frequency of CD8+ T cells in CD3+ cells, all in the peripheral blood. Some mice also had an increase in the CD44 mean fluorescence intensity on total T cells and on CD8+ T cells in the peripheral blood.
Heterozygous: No signficant abnormal phenotype detected.
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Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.