Strain Detail Sheet
Homozygous: Mice exhibit decrease in the frequency of B cells (Figure 1), an increased frequency of B1a cells in B1 cells as well as a reduced frequency of IgM+ B cells and a decrease in the percentage of IgD+ B cells, all in the peripheral blood.
Heterozygous: No signficant abnormal phenotype detected.
Allelic Composition: (Genetic Background: )- hematopoietic system
- increased B-1a cell number [MP:0008167]
- decreased B cell number [MP:0005017]
- immune system
- increased B-1a cell number [MP:0008167]
- decreased B cell number [MP:0005017]
- Immunology and Inflammation
Choi JH, Zeng M, Wang K-W, Murray AR, Beutler B. Record for yosemite. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.
| Viability and Fertility: | Female | Male | Comments |
|---|---|---|---|
| Homozygotes are viable: | |||
| Homozygotes are fertile: | |||
| Heterozygotes are fertile: | |||
| Age Reproductive Decline: | Unknown | Unknown |
The availability level for this product has not been determined.
The donor or their institution limits the distribution to non-profit institutions only.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
- If you register interest in this strain, you will be notified when it becomes available for ordering.