Strain Name:
C57BL/6J-Nlrp3M9Btlr/Mmmh
Stock Number:
038184--TBD-
Citation ID:
RRID:MMRRC_038184--TBD-
Other Names:
Park6
Major Collection:

Strain Information

Nlrp3M9Btlr
Name: NLR family, pyrin domain containing 3; mutation 9, Bruce Beutler
Synonyms: Park6
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: Cias1, NALP3, Pypaf1, Mmig1, cryopyrin
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216799
Homologene: 3600
Genetic Alterations
ENU-induced T to G transition at base pair 59,549,036 (v38) on chromosome 11, or base pair 7,468 in the GenBank genomic region NC_000077 for the Nlrp3 gene. The mutation corresponds to residue 1,664 in the mRNA sequence NM_145827 within exon 4 of 10 total exons. The mutation results in a phenylalanine (F) to valine (V) substitution at position 480 (F480V) in the NLRP3 protein.
Phenotype

Homozygous: Mice exhibit decreased secretion of the proinflammatory cytokine interleukin (IL)-1β in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment.

Heterozygous: Mice exhibit decreased secretion of the proinflammatory cytokine interleukin (IL)-1β in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment. Slightly intermediate effect compared to homozygous and wild-type, but mutation was mapped as dominant inheritance.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

  • immune system
    • decreased interleukin-1 beta secretion [MP:0008658]
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.
  • Immunology and Inflammation
Primary Reference

Shi H, Wang Y, Zhang Z, Dao D, Sun L, Murray AR, Beutler B. Record for Park6. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

For more information about this colony's health status contact
Coat Color
Black
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

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