ENU-induced T to C transition at base pair 113,760,650 (v38) on chromosome 6, or base pair 281,964 in the GenBank genomic region NC_000072 for the Atp2b2 gene. The mutation corresponds to residue 3,402 in the mRNA sequence NM_009723 (variant 1) within exon 18 of 22 total exons and residue 3,213 in the mRNA sequence NM_001036684 (variant 2) within exon 16 of 20 total exons, and residue 3,520 in the cDNA transcript ENSMUST00000101044 (variant 3) within exon 20 of 24 total exons. The mutation results in a leucine (L) to proline (P) substitution at position 925 (L925P) in isoform 1 and 2 and L970P in isoform 3 of the encoded PMCA2 isoforms.

Homozygous: Homozygous lohan exhibited ataxia, head bobbing, limb clasping, and mild tremor.

Heterozygous: No signficant abnormal phenotype detected.

Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.

Wild-type littermates or C57BL/6J mice

The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.