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Gene Information

Name: mitogen-activated protein kinase 3; mutation 1, Bruce Beutler
Synonyms: wabasha
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Name: mitogen-activated protein kinase 3
Synonyms: p44mapk, Mtap2k, p44erk1, Prkm3, Esrk1, Erk-1, p44 MAP kinase, Erk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26417
Homologene: 55682
Genetic Alterations
ENU-induced A to T transversion at base pair 126,763,512 (v38) on chromosome 7, or base pair 4,114 in the GenBank genomic region NC_000073 for the Mapk3 gene. The mutation corresponds to residue 681 in the mRNA sequence NM_011952 within exon 4 of 9 total exons. The mutation results in substitution of lysine (K) 221 to a premature stop codon in the ERK1 (alternatively, p44) protein.

Homozygous: Mice showed decreased secretion of the proinflammatory cytokine interleukin (IL)-1β in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

  • immune system
    • decreased interleukin-1 beta secretion [MP:0008658]
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
  • Immunology and Inflammation
Primary Reference

Shi X, Wang Y, Zhang Z, Dao D, Sun L, Murray AR, Beutler B. Record for wabasha. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

For more information about this colony's health status contact
Coat Color
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

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