Strain Detail Sheet

Strain Name:
C57BL/6J-Nfkb2m2Btlr/Mmmh
Stock Number:
038204--TBD-
Citation ID:
RRID:MMRRC_038204--TBD-
Other Names:
pale_fire
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Nfkb2m2Btlr
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 2, Bruce Beutler
Synonyms: pale_fire
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms: NF kappaB2, p52
Type: Gene
Species: Mouse
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18034
VEGA: 19
HGNC: HGNC:7795
Homologene: 1873
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Additional Resources
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Genetic Alterations
ENU-induced A to T transversion at base pair 46,311,626 (v38) on chromosome 19, or base pair 8,015 in the GenBank genomic region NC_000085 for the Nfkb2 gene. The mutation corresponds to residue 2,821 in the mRNA sequence NM_019408 (variant 1) within exon 21 of 22 total exons, to residue 2,670 in the mRNA sequence NM_001177369 (variant 2) within exon 22 of 23 total exons, and residue 2,586 in the mRNA sequence NM_001177370 (variant 3) within exon 21 of 22 total exons. The mutation results in a methionine (M) to leucine (L) substitution at position 838 (M838L) in all isoforms of the NF-?B2 protein.

Strain Description

Phenotype

Homozygous: Mice exhibited an increased frequency of B1a cells in the peripheral blood.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • hematopoietic system
  • immune system
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Murray AR, Beutler B. Record for pale_fire. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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