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Homozygous: Mice had reduced frequencies of CD8+ T cells (~10% of C57BL/6J), as well as reduced frequencies of na ve CD8+ T cells among total CD8+ T cells, elevated frequencies of central and effector memory CD8+ T cells, and elevated mean fluorescence intensity of CD44 immunostaining on CD8+ T cells, all in the peripheral blood. In addition, increased frequencies of CD4+ T cells were observed among total cells or CD3+ T cells in the peripheral blood (~150% of C57BL/6J). Five days after mouse cytomegalovirus (MCMV) infection, several mice displayed elevated MCMV titers in the spleen, suggesting increased susceptibility to the virus.
Heterozygous: No abnormal phenotype detected.
Zeng M, Moresco EMY, Beutler B. Record for alfalfa. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
The availability level for this product has not been determined.
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