Strain Detail Sheet

Strain Name:
C57BL/6J-Grm7m1Btlr/Mmmh
Stock Number:
038207--TBD-
Citation ID:
RRID:MMRRC_038207--TBD-
Other Names:
shaky
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Grm7m1Btlr
Name: glutamate receptor, metabotropic 7; mutation 1, Bruce Beutler
Synonyms: shaky
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, E130018M02Rik, mGluR7, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
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Genetic Alterations
ENU-induced A to T transversion at base pair 111,495,791 (v38) on chromosome 10, or base pair 850,334 in the GenBank genomic region NC_000072 for the Grm7 gene. The mutation corresponds to residue 2,860 in the NM_177328 mRNA sequence in exon 9 of 10 total exons and residue 2,877 in the ENSMUST00000071076 cDNA sequence in exon 9 of 11 total exons. The mutation results in substitution of lysine 864 (K864) for a premature stop codon (K864*) in all isoforms of the metabotropic glutamate receptor 7 (mGluR7) protein.

Strain Description

Phenotype

Homozygous: Mice exhibited shaking behavior upon scruffing. Some mice also exhibited unilateral forepaw contractions that generalized and resolved within 30 seconds. In addition, the mice were hypersensitive to touch after the seizure when scruffing was attempted again for the next minute. After this episode, the seizure was unable to be provoked again.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • behavior/neurological
  • integument
  • nervous system
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Neurobiology

Strain Origin

Primary Reference

SoRelle J, Wang J, Murray AR, Beutler B. Record for shaky. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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