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Strain Detail Sheet

Strain Name:
C57BL/6J-Slc45a2uw-8Btlr/Mmmh
Stock Number:
038238--TBD-
Citation ID:
RRID:MMRRC_038238--TBD-
Other Names:
cheng
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Slc45a2uw-8Btlr
Name: solute carrier family 45, member 2; underwhite 8 Bruce Beutler
Synonyms: cheng
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Dbr, bls, Aim1, Aim-1, dominant brown, blanc-sale, Matp, Oca4
Type: Gene
Species: Mouse
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22293
Homologene: 9412

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced T to C transition at base pair 11025868 bp (v38) on chromosome 15 in the GenBank genomic region NC_000081 for the Slc45a2 gene. The mutation corresponds to residue 1399 in the mRNA sequence (NM_053077.3) in exon 6 of 7 total exons. The mutation results in a substitution of serine (S) to a proline (P) at residue 435 in the SLC45A2 protein.

Strain Description

Phenotype

Homozygous: Mice exhibit a tan/beige coat color and black eyes.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Cell Biology
  • Models of Human Disease
    • Oculocutaneous albinism type 4 (OCA4, OMIM #606574)

Strain Origin

Primary Reference

Dismang A, Purrington T, Murray AR, Beutler B. Record for cheng. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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