Strain Name:
C57BL/6J-Slc45a2uw-8Btlr/Mmmh
Stock Number:
038238--TBD-
Citation ID:
RRID:MMRRC_038238--TBD-
Other Names:
cheng
Major Collection:

Strain Information

Slc45a2uw-8Btlr
Name: solute carrier family 45, member 2; underwhite 8 Bruce Beutler
Synonyms: cheng
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Dbr, bls, Aim1, Aim-1, dominant brown, blanc-sale, Matp, Oca4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22293
Homologene: 9412
Genetic Alterations
ENU-induced T to C transition at base pair 11025868 bp (v38) on chromosome 15 in the GenBank genomic region NC_000081 for the Slc45a2 gene. The mutation corresponds to residue 1399 in the mRNA sequence (NM_053077.3) in exon 6 of 7 total exons. The mutation results in a substitution of serine (S) to a proline (P) at residue 435 in the SLC45A2 protein.
Phenotype

Homozygous: Mice exhibit a tan/beige coat color and black eyes.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.
  • Cell Biology
  • Models of Human Disease
    • Oculocutaneous albinism type 4 (OCA4, OMIM #606574)
Primary Reference

Dismang A, Purrington T, Murray AR, Beutler B. Record for cheng. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

For more information about this colony's health status contact
Coat Color
Black
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

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