Strain Name:
B6.129P2-Terttm1Leah/Mmucd
Stock Number:
010432-UCD
Citation ID:
RRID:MMRRC_010432-UCD
Other Names:
mTert-/-, B6.129P2-Terttm1Leah/Mmcd

Strain Information

Terttm1Leah
Name: telomerase reverse transcriptase; targeted mutation 1, Lea Harrington
Synonyms: mTert-, Tertdelta
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Knockout
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
Alteration at locus: Knockout
NCBI: 21752
VEGA: 13
Homologene: 31141
Genetic Alterations
PGK-neo disruption of the telomerase-specific motif and the first 3 of 7 reverse transcriptase motifs of Tert
ES Cell Line
E14 derived from 129P2/OlaHsd
Phenotype
Homozygous: Telomere shortening, eventual sterility and genome/telomere instability.

Heterozygous: Intermediate telomere shortening, mice remain fertile and show no evidence of overt genome/telomere instability.
Mammalian Phenotype Terms
Allelic Composition: Terttm1Leah/Terttm1Leah (Genetic Background: involves: 129P2/OlaHsd * C57BL/6J )

Allelic Composition: Terttm1Leah/Tert+ (Genetic Background: involves: 129P2/OlaHsd * C57BL/6J )

MeSH Terms
  • Animals
  • Cell Line
  • DNA-Binding Proteins
  • Gene Targeting
  • Mice
  • RNA
  • Telomerase/genetics
  • Telomerase/metabolism
  • Telomerase/physiology
  • Telomere/physiology
  • Cells, Cultured
  • Chromosome Aberrations
  • Gene Deletion
  • Genome
  • Heterozygote
  • In Situ Hybridization, Fluorescence
  • Metaphase/genetics
  • Protein Transport
  • Stem Cells/cytology
  • Stem Cells/enzymology
  • Stem Cells/metabolism
  • Telomere/enzymology
  • Telomere/genetics
  • Telomere/metabolism
  • Alleles
  • Fertility/genetics
  • Gene Dosage
  • Mice, Inbred C57BL
  • Neoplasms/enzymology
  • Neoplasms/genetics
  • Telomere
Suggested Control Mice
  • Wildtype littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Cancer
  • Models for Human Disease
Donor
Lea Harrington, Ph.D., Ontario Cancer Institute
Primary Reference
  • Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol. 2000 Nov 16;10(22):1459-62. Erratum in: Curr Biol 2001 Jun 5;11(11):907. (Medline PMID: 11102810)
  • Liu Y, Kha H, Ungrin M, Robinson MO, Harrington L. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3597-602. (Medline PMID: 11904422)
  • Erdmann N, Liu Y, Harrington L. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6080-5. Epub 2004 Apr 12. (Medline PMID: 15079066)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
010432-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.