Strain Detail Sheet

Strain Name:
JU/CtLmMmmh
Stock Number:
000136-MU
Citation ID:
RRID:MMRRC_000136-MU
Major Collection:
Mammalian Pigmentation

Strain Information

Gene Details

Genetic Alterations
Not applicable
Genotype Determination

Strain Description

Phenotype
The JU background influences the size and locations of white spots (areas where pigment cells are absent), in differing ways, compared with the C57BL/6J background, when combined with specific white-spotting mutant alleles. The JU background also strongly affects the phenotype of mice mutant at the agouti locus, compared with C57BL/6J mice, but increasing the amount of eumelanin in the coat.

This inbred strain is the background strain and the most appropriate control strain for several other MMRRC strains from the donor's collection. Specifically:
MeSH Terms
  • Agouti Signaling Protein
  • Alleles
  • Animals
  • Chromatography, High Pressure Liquid
  • Genotype
  • Glycoproteins/genetics
  • Intercellular Signaling Peptides and Proteins
  • Intramolecular Oxidoreductases/genetics
  • Melanins/chemistry
  • Melanins/genetics
  • Melanocytes/metabolism
  • Membrane Glycoproteins
  • Mice
  • Mice, Congenic
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Models, Chemical
  • Monophenol Monooxygenase/genetics
  • Mutation
  • Oxidoreductases
  • Phenotype
  • Pigmentation/genetics
  • Proteins/genetics
  • Receptors, Corticotropin/genetics
  • Receptors, Melanocortin
  • Spectrophotometry
  • Melanocytes/physiology
  • Mice, Inbred Strains/genetics
  • Skin Pigmentation/genetics
  • Chromosome Mapping
  • Crosses, Genetic
  • Mice, Inbred Strains
  • Mice, Knockout
  • Mice, Transgenic
  • National Institutes of Health (U.S.)
  • Pigmentation/physiology
  • Research Design
  • United States
Strain Development
Dr. Falconer originally created this strain by crossing several other strains, including C57BL. Dr. Cattanach obtained this stock with albino (mutant tyrosinase) from Falconer in 1966. He subsequently removed the albino allele and in 1973 transfer the strain to Dr. Lamoreux, who subsequently maintained it by brother/sister matings. (Please see MGD's Festing's Inbred Strains of Mice for additional information.)
Suggested Control Mice
  • Not applicable

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Research Applications

  • Inbred control strain for JU/CtLm derived strains
  • Study of the genetic control of background genome over the expression of phenotypes determined at loci where the genotype is not different.

Strain Origin

Donor
Dr. ML Lamoreux, Texas A&M University
Primary Reference
  • Lamoreux ML, Wakamatsu K, Ito S. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res. 2001 Feb;14(1):23-31. (Medline PMID: 11277491)
  • Lamoreux ML. Strain-specific white-spotting patterns in laboratory mice. Pigment Cell Res. 1999 Dec;12(6):383-90. (Medline PMID: 10614578)
  • Lamoreux ML. The inbred mouse in pigmentation research: significance of a congenic developmental system. Pigment Cell Res. 2000 Dec;13(6):421-30. Review. (Medline PMID: 11153693)

Colony and Husbandry Information

Special Considerations

This inbred strain is not intended for breeding except as backcross strain to maintain derived strains in heterozygous state and as experimental controls for those derived strains.

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Sib or Intra-strain mating
Breeding Scheme(s)
Homozygous female x Homozygous male
Generation
F20+
Overall Breeding Performance
Good

Reproductive Statistics

Average litter size
10
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
000136-MU-EMBRYO Cryo-preserved embryos $1,038.00 / $2,621.00
Non-Profit / For-Profit		 Aliquot Approximate quantity2 : 20-40 embryos / aliquot
000136-MU-SPERM Cryo-preserved spermatozoa $437.00 / $817.00
Non-Profit / For-Profit		 Aliquot Approximate quantity3
000136-MU-RESUS Litter recovered from cryo-archive $2,016.00 / $4,103.00
Non-Profit / For-Profit		 Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.