Strain Name:
Stock Number:
Citation ID:

Gene Information

Name: axin 2
Synonyms: Axil, Conductin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Transgenic
NCBI: 12006
Homologene: 3420
Type: Gene
Species: Aequorea victoria (jellyfish)
Alteration at locus: Transgenic
Name: transgene insertion 5, Frank Costantini
Synonyms: Tg(Axin2-EGFP)1Cos, Ax2/d2EGFP
Type: Transgene
Species: Mus musculus (mouse)
Chromosome: unknown
Alteration at locus: Transgenic
Genetic Alterations
Axin2 regulatory elements (promoter and first intron) were joined to d2EGFP (a form of EGFP with a short half-life, Clontech), and vector sequences were removed before microinjection to generate transgenic lines.
Genotype Determination
  • Genotyping Protocol(s)
  • Center protocol and contact for technical support will be shipped with mice.
  • Phenotype
    Homozygous and Hemizygous: none except expression of d2EGFP
    MeSH Terms
    • Animals
    • Axin Protein
    • Binding Sites
    • Cell Line
    • Cytoskeletal Proteins/genetics
    • Cytoskeletal Proteins/metabolism
    • DNA-Binding Proteins/metabolism
    • Embryo, Mammalian/metabolism
    • Gene Expression Regulation/physiology
    • Genes, Reporter
    • Green Fluorescent Proteins
    • Humans
    • In Situ Hybridization
    • Indicators and Reagents/metabolism
    • Luminescent Proteins/genetics
    • Luminescent Proteins/metabolism
    • Lymphoid Enhancer-Binding Factor 1
    • Mice
    • Mice, Transgenic
    • Models, Biological
    • Proto-Oncogene Proteins/metabolism
    • Recombinant Fusion Proteins/genetics
    • Recombinant Fusion Proteins/metabolism
    • Regulatory Sequences, Nucleic Acid
    • Signal Transduction/physiology
    • Trans-Activators
    • Transcription Factors/metabolism
    • Wnt Proteins
    • Zebrafish Proteins
    • beta Catenin
    Strain Development
    Transgenic mouse derived by microinjection into B6CBAF1 x B6CBAF1 zygote. Maintained by backcross to C57BL/6.
    Suggested Control Mice

    Wild-type littermates

    • Cancer
    • Cell Biology
    • Dermatology
    • Developmental Biology
    • Internal/Organ
    • Neurobiology
    • Research Tools
    Frank Costantini, Ph.D., Columbia University Medical Center
    Primary Reference
    Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol. 2002 Feb;22(4):1172-83. (Medline PMID: 11809808)

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
    Donating Investigator submitted mice that had been backcrossed 3-4 generations

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    015749-UNC-RESUS Litter recovered from cryo-archive $2,829.00 / $4,696.00
    Non-Profit / For-Profit
    Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to for more information.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.