Allele Symbol: Mc5rtm1Cone
Name: targeted mutation 1, Roger D Cone
Alteration at locus: Knockout
Gene Symbol: Mc5r
Name: melanocortin 5 receptor
Alteration at locus: Knockout
ES Cell Line: AK7 derived from 129S4/SvJaeSor
Homozygous phenotype: The MC5-R knockout
mouse is characterized by defects in exocrine function. Of those
described are a defect in production and stress-related synthesis of
porphyrins by the harderian gland, defects in the ACTH/MSH regulated
protein secretion by the lacrimal gland, and decreased production of
sebacious lipids. The MC5-R is implicated in pheremone-induced
aggression as the knockout mouse displays reduced pheremonal signalling
for aggression in male mice acting on donors rather than their opponents.
Heterozygous phenotype: The heterozygous MC5-R mouse exhibits an intermediate phenotype relative to that of the wild-type and knockout mouse.
Strain of Origin: C57BL/6J
Strain genetic background: C57BL/6J
Strain Development: Positive ES cells were microinjected into blastocysts of C57BL/6J mice. The two clones were backcrossed 7-9 generations into C57BL/6J to make congenic strains.
Suggested Control Mice:
Donor: Roger D. Cone, Ph.D., Vanderbilt University
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Fee/unit (US $)
|Litter||Recovered litter1; additional fees for any special requests.|
|Aliquot||Approximate quantity3: 20-40 embryos / aliquot|
1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.