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Strain Name:
TINT/ArtMmnc
Stock Number:
017248-UNC
Citation ID:
RRID:MMRRC_017248-UNC
Other Names:
BTBRTF/2ArtMmnc

Strain Information

tint
Name: tail interaction with T complex; interaction with T complex
Synonyms: t-int
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Spontaneous Mutation
Itpr3tf
Name: inositol 1,4,5-triphosphate receptor 3; tufted
Synonyms: tf
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Spontaneous Mutation
Genotype Determination
  • Genotyping Protocol(s)
  • Center protocol and contact for technical support will be shipped with mice.
  • Phenotype
    Homozygous: Cross to brachyury ("T") deletion (MGI:1856184) produces tailless and normal (i.e., no short tails).

    Heterozygous: Normal tail
    MeSH Terms
    • Animals
    • Crosses, Genetic
    • Female
    • Genotype
    • Hair
    • Male
    • Mice/genetics
    • Mutation
    • Phenotype
    • Tail/anatomy & histology
    • Chromosome Mapping
    • Chromosomes
    • Enhancer Elements, Genetic
    • Fetal Proteins/genetics
    • Mice
    • Notochord
    • T-Box Domain Proteins/genetics
    Strain GQC Summary
    Gene Specific Genotyping:

    To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

    Background Genetic Quality:

    The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

    Suggested Control Mice
    Littermates of all relevant genotypes.
    • Models for Human Disease
    • True modifier of Brachy tail length
    Submitter
    Karen Artzt, Ph.D., University of Texas at Austin.
    Primary Reference

    Artzt K, Cookingham J, Bennett D. A new mutation (t-int) interacts with the mutations of the mouse T/t complex that affect the tail. Genetics. 1987 Aug;116(4):601-5. (Medline PMID: 3623082)

    Wu JI, Centilli MA, Vasquez G, Young S, Scolnick J, Durfee LA, Spearow JL, Schwantz SD, Rennebeck G, Artzt K. Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. Genetics. 2007 Oct;177(2):1151-61. (Medline PMID: 17954925)

    Lyon, MF. Hereditary hair loss in the tufted mutant of the house mouse. J. Hered, Volume 47, Issue 2, 1956 Mar;47(2):101–103, https://doi.org/10.1093/oxfordjournals.jhered.a106601

    Strain Development
    The mutation was isolated from a viable t-haplotype (tw111) so it has wild and non-inbred mixed components, but it is now inbred (F96).

    Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain's tissue samples taken when archived by or ordered from the assigned MMRRC Center.

    Colony and Husbandry Information

    Feed mouse chowwith high lipid content for nursing mothers: usually, mothers are notremoved from the parental cage. Raise one litter in the same cage as alladults with males - the litter will survive and thrive.

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc_health@med.unc.edu.
    Coat Color
    Albino
    Eye
    Red
    MMRRC Breeding System
    Sib-mating
    Generation
    F96
    Overall Breeding Performance

    Excellent

    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Yes Yes
    Homozygotes are fertile: Yes Yes
    Heterozygotes are fertile: Yes Yes
    Age Reproductive Decline: 10 months 10 months
    Bred to Homozygosity
    Yes
    Average litter size
    12 pups
    Recommended wean age
    4 weeks
    Average Pups Weaned
    8 pups

    Order Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@med.unc.edu for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The submitter or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $)
    *Shipping & Handling not included*
    Units Notes
    017248-UNC-EMBRYO Cryo-preserved embryos $1,718.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
    017248-UNC-RESUS Litter recovered from cryo-archive $3,566.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@med.unc.edu for more information.

    1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.