Strain Detail Sheet
Strain Name:
STOCK Myt1tm1Ggu/Mmnc
Stock Number:
030295-UNC
Citation ID:
RRID:MMRRC_030295-UNC
Other Names:
Myelin transcription factor 1
Myt1tm1Ggu
Name: myelin transcription factor 1; targeted mutation 1, Guoqiang Gu
Synonyms: Myt1f
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Targeted Mutation
MGI: MGI:3765054
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Targeted Mutation
MGI: MGI:1100535
NCBI: 17932
Ensembl: ENSMUSG00000010505
VEGA: OTTMUSG00000016812
HGNC: HGNC:7622
Homologene: 3332
UCSC: Chr2:181405099-181469579
Genetic Alterations
two loxp sites flank exon #6 of Myt1b
Genotype Determination
ES Cell Line
TL1/TL-1 derived from 129S6/SvEvTac
Phenotype
Homozygous: Abnormal endocrine differentiation and function. Reduced vagal nerve axon development.
Heterozygous: Same as wild-type
Heterozygous: Same as wild-type
MeSH Terms
- Animals
- Basic Helix-Loop-Helix Transcription Factors/metabolism
- Cell Differentiation
- DNA-Binding Proteins/chemistry
- DNA-Binding Proteins/deficiency
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- Gene Expression Regulation, Developmental
- Gene Targeting
- Glucose/metabolism
- Homeodomain Proteins/metabolism
- Insulin/secretion
- Integrases/metabolism
- Islets of Langerhans/cytology
- Islets of Langerhans/embryology
- Islets of Langerhans/physiology
- Islets of Langerhans/secretion
- Male
- Mice
- Mutation/genetics
- Nerve Tissue Proteins/metabolism
- Organ Specificity
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Sequence Homology, Amino Acid
- Stem Cells/cytology
- Trans-Activators/metabolism
- Transcription Factors/chemistry
- Transcription Factors/deficiency
- Transcription Factors/genetics
- Transcription Factors/metabolism
Strain Development
129S6 ES cell derived chimera was crossed with C57BL/6. Subsequent production uses CD1 (ICR).
Suggested Control Mice
Wildtype littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@med.unc.edu. Older strains may not have this information.
- Cell Biology
- Developmental Biology
- Diabetes/Obesity
- Endocrine Deficiency
- Models for Human Disease
- Neurobiology
Donor
Guoqiang Gu, Ph.D., Vanderbilt Medical Center
Primary Reference
Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910. Epub 2007 Sep 4. (Medline PMID: 17928203)
Colony Surveillance Program and Current Health Reports
For more information about this colony's health status contact mmrrc_health@med.unc.eduMMRRC Breeding System
Intra-strain
Breeding Scheme(s)
Intra-strain
The availability level for this product has not been determined.
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