Phenotype
Homozygous: Abnormal endocrine differentiation and function. Reduced vagal nerve axon development.
Heterozygous: Same as wild-type
MeSH Terms
- Animals
- Basic Helix-Loop-Helix Transcription Factors/metabolism
- Cell Differentiation
- DNA-Binding Proteins/chemistry
- DNA-Binding Proteins/deficiency
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- Gene Expression Regulation, Developmental
- Gene Targeting
- Glucose/metabolism
- Homeodomain Proteins/metabolism
- Insulin/secretion
- Integrases/metabolism
- Islets of Langerhans/cytology
- Islets of Langerhans/embryology
- Islets of Langerhans/physiology
- Islets of Langerhans/secretion
- Male
- Mice
- Mutation/genetics
- Nerve Tissue Proteins/metabolism
- Organ Specificity
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Sequence Homology, Amino Acid
- Stem Cells/cytology
- Trans-Activators/metabolism
- Transcription Factors/chemistry
- Transcription Factors/deficiency
- Transcription Factors/genetics
- Transcription Factors/metabolism
Strain Development
129S6 ES cell derived chimera was crossed with C57BL/6. Subsequent production uses CD1 (ICR).