Strain Name:
STOCK Myt1tm1Ggu/Mmnc
Stock Number:
030295-UNC
Citation ID:
RRID:MMRRC_030295-UNC
Other Names:
Myelin transcription factor 1

Strain Information

Myt1tm1Ggu
Name: myelin transcription factor 1; targeted mutation 1, Guoqiang Gu
Synonyms: Myt1f
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Targeted Mutation
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Targeted Mutation
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Genetic Alterations
two loxp sites flank exon #6 of Myt1b
Genotype Determination
  • Genotyping Protocol(s)
  • Center protocol and contact for technical support will be shipped with mice.
  • ES Cell Line
    TL1/TL-1 derived from 129S6/SvEvTac
    Phenotype
    Homozygous: Abnormal endocrine differentiation and function. Reduced vagal nerve axon development.

    Heterozygous: Same as wild-type
    MeSH Terms
    • Animals
    • Basic Helix-Loop-Helix Transcription Factors/metabolism
    • Cell Differentiation
    • DNA-Binding Proteins/chemistry
    • DNA-Binding Proteins/deficiency
    • DNA-Binding Proteins/genetics
    • DNA-Binding Proteins/metabolism
    • Gene Expression Regulation, Developmental
    • Gene Targeting
    • Glucose/metabolism
    • Homeodomain Proteins/metabolism
    • Insulin/secretion
    • Integrases/metabolism
    • Islets of Langerhans/cytology
    • Islets of Langerhans/embryology
    • Islets of Langerhans/physiology
    • Islets of Langerhans/secretion
    • Male
    • Mice
    • Mutation/genetics
    • Nerve Tissue Proteins/metabolism
    • Organ Specificity
    • RNA, Messenger/genetics
    • RNA, Messenger/metabolism
    • Sequence Homology, Amino Acid
    • Stem Cells/cytology
    • Trans-Activators/metabolism
    • Transcription Factors/chemistry
    • Transcription Factors/deficiency
    • Transcription Factors/genetics
    • Transcription Factors/metabolism
    Strain Development
    129S6 ES cell derived chimera was crossed with C57BL/6. Subsequent production uses CD1 (ICR).
    Suggested Control Mice

    Wildtype littermates

    MMRRC Genetic QC Summary
    The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@med.unc.edu. Older strains may not have this information.
    • Cell Biology
    • Developmental Biology
    • Diabetes/Obesity
    • Endocrine Deficiency
    • Models for Human Disease
    • Neurobiology
    Donor
    Guoqiang Gu, Ph.D., Vanderbilt Medical Center
    Primary Reference
    Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910. Epub 2007 Sep 4. (Medline PMID: 17928203)

    Colony and Husbandry Information

    MMRRC Breeding System
    Intra-strain
    Breeding Scheme(s)
    Intra-strain

    Order Request Information

    The availability level for this product has not been determined.

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