Strain Name:
STOCK Myt1tm1Ggu/Mmnc
Stock Number:
030295-UNC
Citation ID:
RRID:MMRRC_030295-UNC
Other Names:
Myelin transcription factor 1

Gene Information

Allele Symbol: Myt1tm1Ggu (Mus musculus (mouse))
Name: myelin transcription factor 1; targeted mutation 1, Guoqiang Gu
Synonyms: Myt1
Chromosome: 2
Alteration at locus: Targeted Mutation
Monarch Initiative (Disease and Phenotype Associations): MGI:3765054
Gene Symbol: Myt1 (Mus musculus (mouse))
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Chromosome: 2
Alteration at locus: Targeted Mutation
Monarch Initiative (Disease and Phenotype Associations): MGI:1100535
Genetic Alterations
two loxp sites flank exon #6 of Myt1b
Genotype Determination
  • Genotyping Protocol(s)
  • Center protocol and contact for technical support will be shipped with mice.
  • ES Cell Line
    TL1/TL-1 derived from 129S6/SvEvTac
    Phenotype
    Homozygous: Abnormal endocrine differentiation and function. Reduced vagal nerve axon development.

    Heterozygous: Same as wild-type
    MeSH Terms
    • Animals
    • Basic Helix-Loop-Helix Transcription Factors/metabolism
    • Cell Differentiation
    • DNA-Binding Proteins/chemistry
    • DNA-Binding Proteins/deficiency
    • DNA-Binding Proteins/genetics
    • DNA-Binding Proteins/metabolism
    • Gene Expression Regulation, Developmental
    • Gene Targeting
    • Glucose/metabolism
    • Homeodomain Proteins/metabolism
    • Insulin/secretion
    • Integrases/metabolism
    • Islets of Langerhans/cytology
    • Islets of Langerhans/embryology
    • Islets of Langerhans/physiology
    • Islets of Langerhans/secretion
    • Male
    • Mice
    • Mutation/genetics
    • Nerve Tissue Proteins/metabolism
    • Organ Specificity
    • RNA, Messenger/genetics
    • RNA, Messenger/metabolism
    • Sequence Homology, Amino Acid
    • Stem Cells/cytology
    • Trans-Activators/metabolism
    • Transcription Factors/chemistry
    • Transcription Factors/deficiency
    • Transcription Factors/genetics
    • Transcription Factors/metabolism
    Strain Development
    129S6 ES cell derived chimera was crossed with C57BL/6. Subsequent production uses CD1 (ICR).
    Suggested Control Mice
    • Wildtype littermates
    • Cell Biology
    • Developmental Biology
    • Diabetes/Obesity
    • Endocrine Deficiency
    • Models for Human Disease
    • Neurobiology
    Donor
    Guoqiang Gu, Ph.D., Vanderbilt Medical Center
    Primary Reference
    Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910. Epub 2007 Sep 4. (Medline PMID: 17928203)

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc_health@med.unc.edu .

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    030295-UNC-SPERM Cryo-preserved spermatozoa $548.00 / $910.00
    Non-Profit / For-Profit
    Aliquot Approximate quantity2
    030295-UNC-RESUS Litter recovered from cryo-archive $2,829.00 / $4,696.00
    Non-Profit / For-Profit
    Litter Recovered litter1; additional fees for any special requests.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.