Strain Name:
B6.129P2(FVB)-Fabp3tm1Bin/Mmmh
Stock Number:
030489-MU
Citation ID:
RRID:MMRRC_030489-MU

Strain Information

Fabp3tm1Bin
Name: fatty acid binding protein 3, muscle and heart; targeted mutation 1, Bert Binas
Synonyms: H-FABP-
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Knockout
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: H-FABP, Fabph-4, Fabph-1, Fabph4, Fabph1, Mdgi, Fabp3
Type: Gene
Species: Mouse
Chromosome: 4
Alteration at locus: Knockout
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Genotype Determination
ES Cell Line
AB1 derived from 129S7/SvEvBrd-Hprt+
Phenotype
Homozygous: Exercise intolerant. Cardiac hypertrophy with age.

Heterozygous: Absence of insulin resistance with dietary obesity as heterozygote.
Mammalian Phenotype Terms
Allelic Composition: Fabp3tm1Bin/Fabp3tm1Bin (Genetic Background: involves: 129P2/OlaHsd * BALB/c )

MeSH Terms
  • 3-Hydroxybutyric Acid/blood
  • Animals
  • Blood Glucose/metabolism
  • Cardiomegaly/genetics
  • Cardiomegaly/metabolism
  • Cardiomegaly/pathology
  • Carrier Proteins/genetics
  • Carrier Proteins/metabolism
  • Disease Models, Animal
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids/blood
  • Fatty Acids/metabolism
  • Fatty Acids/pharmacokinetics
  • Female
  • Iodine Radioisotopes
  • Iodobenzenes/pharmacokinetics
  • Lactic Acid/blood
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Myelin P2 Protein/genetics
  • Myelin P2 Protein/metabolism
  • Myocardium/metabolism
  • Myocardium/pathology
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Blood Glucose
  • Chromosome Mapping
  • Fatty Acid Binding Protein 3
  • Fatty Acid-Binding Proteins/deficiency
  • Fatty Acid-Binding Proteins/genetics
  • Fatty Acids, Nonesterified/blood
  • Glucose/metabolism
  • Insulin/blood
  • Insulin Resistance/genetics
  • Insulin Resistance/physiology
  • Sequence Deletion/genetics
  • Homeostasis/physiology
  • Metabolic Clearance Rate
  • Mice, Inbred C57BL
  • Muscle, Skeletal/physiology
  • Physical Conditioning, Animal/physiology
  • Physical Exertion/physiology
Strain Development
Homologous recombination of FABP3 with backcross to C57BL/6 background for metabolic studies.
Suggested Control Mice

Wildtype littermates

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
  • Cardiovascular
  • Diabetes/Obesity
  • Models for Human Disease
Donor
Jeffrey Rottman, M.D., Vanderbilt University
Primary Reference
  • Binas B, Danneberg H, McWhir J, Mullins L, Clark AJ. Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization. FASEB J. 1999 May;13(8):805-12. (Medline PMID: 10224224)
  • Shearer J, Fueger PT, Bracy DP, Wasserman DH, Rottman JN. Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance. 2005 Nov;54(11):3133-9. (Medline PMID: 16249436)
  • Shearer J, Fueger PT, Rottman JN, Bracy DP, Binas B, Wasserman DH. Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise. Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E292-7. Epub 2004 Sep 28. (Medline PMID: 15454399)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
030489-MU-SPERM Cryo-preserved spermatozoa $437.00 / $817.00
Non-Profit / For-Profit
Aliquot Approximate quantity3
030489-MU-RESUS Litter recovered from cryo-archive $2,624.00 / $5,340.00
Non-Profit / For-Profit
Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.