Strain Name:
FVB.129X1-Jak2tm1.1Kuw/Mmmh
Stock Number:
030910-MU
Citation ID:
RRID:MMRRC_030910-MU

Gene Information

Jak2tm1.1Kuw
Name: Janus kinase 2; targeted mutation 1.1, Kay-Uwe Wagner
Synonyms: Jak2-
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Knockout
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Knockout
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Genotype Determination
ES Cell Line
RW-4 derived from 129X1/SvJ
Phenotype
Homozygous: Embryonic lethal on day 12.5 due to impaired definitive erythropoiesis

Heterozygous: Same as wild-type
Mammalian Phenotype Terms
Allelic Composition: Jak2tm1.1Kuw/Jak2tm1.1Kuw (Genetic Background: involves: 129X1/SvJ )

MeSH Terms
  • Animals
  • Erythropoiesis/genetics
  • Exons/genetics
  • Female
  • Fetal Death/genetics
  • Gene Deletion
  • Janus Kinase 2
  • Mammary Tumor Virus, Mouse/genetics
  • Mice
  • Mice, Knockout
  • Pregnancy
  • Protein-Tyrosine Kinases/deficiency
  • Protein-Tyrosine Kinases/genetics
  • Proto-Oncogene Proteins/deficiency
  • Proto-Oncogene Proteins/genetics
Suggested Control Mice

Wildtype littermates

  • Cancer
  • Cell Biology
  • Developmental Biology
  • Endocrine Deficiency
  • Hematology
  • Immunology and Inflammation
  • Metabolism
  • Models for Human Disease
  • Reproduction
Donor
Kay-Uwe Wagner, Ph.D., University of Nebraska Medical Center
Primary Reference
Krempler A, Qi Y, Triplett AA, Zhu J, Rui H, Wagner KU. Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis. 2004 Sep;40(1):52-7. (Medline PMID:15354294)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
030910-MU-SPERM Cryo-preserved spermatozoa $437.00 / Non-Profit Aliquot Approximate quantity3
030910-MU-RESUS Litter recovered from cryo-archive $2,697.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.