Strain Name:
B6.129X1-Ntrk3tm1(cre)Lfr/Mmucd
Stock Number:
000364-UCD
Citation ID:
RRID:MMRRC_000364-UCD

Gene Information

Ntrk3tm1(cre)Lfr
Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Louis F Reichardt
Synonyms: Ntrk3tm1(cre)Rice, Ntrk3tm(cre)1Lfr
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Knock-In
cre
Name: cre recombinase
Type: Gene
Species: Enterobacteria phage P1 (bacteriophage P1)
Alteration at locus: Knock-In
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Knock-In
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Genetic Alterations
IRES-dre (internal ribosome entry site) was inserted into last coding exon of full-length kinase-containing isoform of TrkC (exon 18)
Genotype Determination
ES Cell Line
Not specified
Phenotype

Homozygotes: viable, fertil, normal. Expresses cre-recombinase in all cells that express TrkC kinase.

Heterozygotes: viable, fertil, normal.

Mammalian Phenotype Terms
Allelic Composition: Ntrk3tm1(cre)Lfr/Ntrk3+ (Genetic Background: involves: C57BL/6 )

MeSH Terms
  • Animals
  • Blood Vessels/cytology
  • Blood Vessels/metabolism
  • Dermis/blood supply
  • Dermis/cytology
  • Dermis/innervation
  • Dermis/metabolism
  • Epidermis/cytology
  • Epidermis/innervation
  • Epidermis/metabolism
  • Face/innervation
  • Female
  • Genes, Reporter
  • Hair Follicle/cytology
  • Hair Follicle/metabolism
  • Male
  • Mechanoreceptors/cytology
  • Mechanoreceptors/metabolism
  • Merkel Cells/cytology
  • Merkel Cells/metabolism
  • Mice
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Neurons, Afferent/cytology
  • Neurons, Afferent/metabolism
  • Protein Engineering/methods
  • Protein Isoforms
  • Receptor, trkA/genetics
  • Receptor, trkA/metabolism
  • Receptor, trkC/genetics
  • Receptor, trkC/metabolism
  • Schwann Cells/cytology
  • Schwann Cells/metabolism
  • Trigeminal Ganglion/cytology
  • Trigeminal Ganglion/growth & development
  • Trigeminal Ganglion/metabolism
Suggested Control Mice
Wild-type littermates
  • Dermatology
  • Developmental Biology
  • Neurobiology
  • Sensorineural
Donor
Louis F. Reichardt, Ph.D., University of California - San Francisco
Primary Reference
Funfschilling U, Ng YG, Zang K, Miyazaki J, Reichardt LF, Rice FL. TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol. 2004 Dec 20;480(4):392-414. (Medline PMID: 15558783)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu .
Coat Color
Mixed
MMRRC Breeding System
The MMRRC has always maintained this strain in a cryopreserved format. Information in the "Breeding" and "Reproductive statistics" sections has been provided by the Donating Investigator
Breeding Scheme(s)
  • C57BL/6Crl female x Heterozygous male
Generation
N7 As of: 1/2005
Overall Breeding Performance
similar to C57BL/6
Average litter size
7
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
000364-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity3 : 20-40 embryos / aliquot
000364-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity2
000364-UCD-RESUS Litter recovered from cryo-archive $3,033.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.