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Strain Name:
B6.Cg-Ush1gjs-bkup/Mmucd
Stock Number:
036536-UCD
Citation ID:
RRID:MMRRC_036536-UCD
Other Names:
backup

Strain Information

Ush1gjs-bkup
Name: USH1 protein network component sans; backup
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Spontaneous Mutation
Ush1g
Name: USH1 protein network component sans
Synonyms: js, Sans
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Spontaneous Mutation
NCBI: 16470
Homologene: 56113
Genetic Alterations
The mutation was identified as the creation of a stop codon at amino acid 4 (CAG to TAG) in the Ush1g gene.test
Genotype Determination
Phenotype

Homozygous: backward walking

Heterozygous: indistinguishable from wild-type animals

Strain Development
This strain was discovered in a colony of Neil1 knock out mice, in which 2 mice were hyperactive (forward running), would only walk backward in an open-field environment, failed swim test, and were deaf at birth. Bred onto a wild-type C57BL/6 background and the defect tracks as a recessive, with no phenotype in heterozygous mice. The mutation was identified as the creation of a stop codon at amino acid 4 (CAG to TAG) in the Ush1g gene.
The strain is on a congenic C57BL/6 background; involves C57BL/6 and unspecified strains.
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Developmental Biology
  • Internal Organ
  • Metabolism
  • Neurobiology
  • Research Tools
  • Sensorineural
Donor
R. Stephen Lloyd, Ph.D., Oregon Health & Science Universty.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.
Coat Color
Black
Other
backward walking
Download Video
MMRRC Breeding System
Sib-mating
Breeding Scheme(s)
  • Heterozygous female x Heterozygous male littermate
  • Heterozygous female x Homozygous male littermate
  • affected females become pregnant and give live births, but all pups die due to being ignored by the mother
Generation
N21
Overall Breeding Performance
Excellent
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Undetermined Undetermined
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
036536-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
036536-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
036536-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.