Homozygous: Mice are normal prior to Cre expression.
Heterozygous: Mice are normal prior to Cre expression.
Teng L, Mundell NA, Frist AY, Wang Q, Labosky PA. Requirement for Foxd3 in Maintenance of Neural Crest Progenitors. Development. 2008 May;135(9):1615-24. Epub 2008 Mar 26. (Medline PMID: 18367558).
Liu Y, Labosky PA. Regulation of ES Cell Self-renewal and Pluripotency by Foxd3. Stem Cells. 2008 Oct;26(10):2475-84. Epub 2008 Jul 24. (Medline PMID: 18653770).
Mundell NA, Labosky PA. Neural Crest Stem Cell Multipotency Requires Foxd3 to Maintain Neural Potential and Repress Mesenchymal Fates. Development. 2011 Feb;138(4):641-52. Epub 2011 Jan 12. (Medline PMID: 21228004).
Heterozygous female x Heterozygous male sibling
Homozygous female x Homozygous male sibling
CD1 female x Heterozygous male or reciprocal mating
|Viability and Fertility:||Female||Male||Comments|
|Homozygotes are viable:||Yes||Yes|
|Homozygotes are fertile:||Yes||Yes|
|Heterozygotes are fertile:||Yes||Yes|
|Age Reproductive Decline:||6 months||12 months|
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to email@example.com for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
|MMRRC Item #||Description||Distribution Fee / Unit (US $)||Units||Notes|
|036674-MU-SPERM||Cryo-preserved spermatozoa||$437.00 / $817.00
Non-Profit / For-Profit
|036674-MU-RESUS||Litter recovered from cryo-archive||$2,624.00 / $5,340.00
Non-Profit / For-Profit
|Litter||Recovered litter1; additional fees for any special requests.|
|Cryopreserved material may be available upon request, please inquire to firstname.lastname@example.org for more information.|
1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.