Strain Name:
Stock Number:
Citation ID:
Other Names:
NeuroD/lacZ Knock-In, B6;129S4-Neurod1tm1Jle/Mmcd

Strain Information

Name: neurogenic differentiation 1; targeted mutation 1, Jacqueline E Lee
Synonyms: NeuroD1:lacZ, Neurod1tmAK71(lacZ)Jle, Neurod1Z, ND -
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Knock-In
Name: neurogenic differentiation 1
Synonyms: BETA2, Neurod, bHLHa3, Nd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Knock-In
NCBI: 18012
Homologene: 1871
Genetic Alterations
LacZ-pA-(inverted PKG-neo) cassette was inserted between +1484 (Asp718; within the intron) and +3134 (SpeI; within the 3'UTR) sites. CDS: +1715 to +2788.
Genotype Determination
ES Cell Line
AK7 derived from 129S4/SvJaeSor
Homozygous: Postnatal lethal due to neonatal diabetes Pancreas--5% insulin production, no islet formation Gut--no CCK or secretin production Inner ear defects resulting in deafness--no cochlear ganglia and poor vestibular ganglia formation Cerebellar defect resulting in ataxia-- >90% depletion of cerebellar granule cells Hippocampal defects--no dentate gyrus
Mammalian Phenotype Terms
Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle (Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 )

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle (Genetic Background: involves: 129S4/SvJaeSor * ICR )

MeSH Terms
  • Animals
  • Apoptosis
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Count
  • Cell Differentiation
  • Cerebellum/cytology
  • Cerebellum/growth & development
  • Cerebellum/pathology
  • Genetic Therapy
  • Hippocampus/cytology
  • Hippocampus/growth & development
  • Hippocampus/pathology
  • In Situ Nick-End Labeling
  • Insulin/genetics
  • Mice
  • Mice, Knockout
  • Mice, Neurologic Mutants
  • Mice, Transgenic
  • Nerve Tissue Proteins/deficiency
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/physiology
  • Neurons/cytology
  • Phenotype
  • Promoter Regions, Genetic
  • Recombinant Fusion Proteins/physiology
  • Transgenes
  • Cell Death
  • Cell Movement
  • Cell Survival
  • Cochlea/growth & development
  • Cochlea/innervation
  • Cochlea/pathology
  • Cochlea/ultrastructure
  • Deafness/genetics
  • Deafness/physiopathology
  • Evoked Potentials, Auditory/genetics
  • Evoked Potentials, Auditory/physiology
  • Gene Deletion
  • Gene Expression Regulation, Developmental
  • Genes, Reporter
  • Hair Cells, Auditory, Inner/growth & development
  • Hair Cells, Auditory, Inner/metabolism
  • Hair Cells, Auditory, Inner/pathology
  • Hair Cells, Auditory, Inner/ultrastructure
  • Helix-Loop-Helix Motifs
  • Histocytochemistry
  • In Situ Hybridization
  • Microscopy, Electron
  • Nerve Tissue Proteins/chemistry
  • Neural Pathways/growth & development
  • Neural Pathways/pathology
  • Receptor, trkB/genetics
  • Receptor, trkB/metabolism
  • Receptor, trkC/genetics
  • Receptor, trkC/metabolism
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact Older strains may not have this information.
  • Apoptosis
  • Cell Biology
  • Developmental Biology
  • Diabetes/Obesity
  • Endocrine Deficiency
  • Metabolism
  • Models for Human Disease
  • Neurobiology
  • Sensorineural
Jackie Lee, Ph.D., University of Colorado at Boulder
Primary Reference
  • Miyata T, Maeda T, Lee JE. NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 1999 Jul 1;13(13):1647-52. (Medline PMID: 10398678)
  • Kim WY, Fritzsch B, Serls A, Bakel LA, Huang EJ, Reichardt LF, Barth DS, Lee JE. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development. 2001 Feb;128(3):417-26. (Medline PMID: 11152640)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
Coat Color
MMRRC Breeding System
Breeding Scheme(s)
  • Heterozygous female x Wild type male
Overall Breeding Performance
Average litter size
6 - 8
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
000367-UCD-RESUS Litter recovered from cryo-archive $3,033.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to for more information.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.