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Availability & Fees Order this Strain
Homozygous: mice fail to thrive ~E7.5 or earlier.
Heterozygous: mice are fully viable and fertile. Munc18c protein is required for vesicle exocytosis in some but not all cell types. The heterozygous mice are phenotypically normal overall, yet have inherent defects in insulin secretion from pancreatic beta cells coupled with defective glucose clearance mechanisms in the skeletal muscle. When stressed using a high fat diet, the Munc18c heterozygous mice become strikingly insulin and glucose intolerant with fasting hyperglycemia, indicative of diabetes.
Oh E, Spurlin BA, Pessin JE, Thurmond DC. Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance. Diabetes. 2005 Mar;54(3):638-47. (Medline PMID: 15734838).
Oh E, Thurmond DC. Munc18c depletion selectively impairs the sustained phase of insulin release. Diabetes. 2009 May;58(5):1165-74. Epub 2009 Feb 2. (Medline PMID: 19188424).
Schraw TD, Crawford GL, Ren Q, Choi W, Thurmond DC, Pessin J, Whiteheart SW. Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release. Thromb Haemost. 2004 Oct;92(4):829-37. (Medline PMID: 15467915).
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.