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Strain Detail Sheet

Strain Name:
C57BL/6J-Hmga1em1Mbp/Mmucd
Stock Number:
037478-UCD
Citation ID:
RRID:MMRRC_037478-UCD
Other Names:
C57BL/6J-Hmga1; Hmga1 KO

Strain Information

Gene Details

Hmga1em1Mbp
Name: high mobility group AT-hook 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: TALEN
Hmga1
Name: high mobility group AT-hook 1
Synonyms: HMGY, HMG-I(Y), Hmgi, Hmgiy, HMGI(Y), Hmga1b, Hmga1a
Type: Gene
Species: Mouse
Chromosome: 17
Alteration at locus: TALEN
NCBI: 15361
HGNC: HGNC:5010
Homologene: 128226

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
TALEN-medicated 7-bp deletion and premature stop codon in exon 1 of the Hmga1 gene.
Genotype Determination
Genotyping Protocol
    ES Cell Line
    Not applicable

    Strain Description

    Phenotype

    Homozygous: Not characterized

    Hetero/Hemizygous: Not characterized

    Strain Development

    Mice were generated on the C57BL/6J background, using TALEN technology, targeting exon 1 of the Hmga1 gene in the Mouse Biology Program. Founder line #18.

    Suggested Control Mice
    Wild-type littermates

    MMRRC Genetic QC

    MMRRC Genetic QC Summary
    The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.

    Research Applications

    • Diabetes
    • Models for Human Disease

    Strain Origin

    Donor
    Kent Lloyd, D.V.M., University of California, Davis.

    Colony and Husbandry Information

    Health Status Report

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.

    Appearance

    Coat Color
    Black
    Eye
    Black

    Breeding

    MMRRC Breeding System
    Backcross
    Breeding Scheme(s)
    Founder x B6, progeny x B6. Sibling het x het for future phenotyping.
    Generation
    "N1" (C57BL/6J)
    Overall Breeding Performance
    Undetermined

    Reproductive Statistics

    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Undetermined Undetermined
    Homozygotes are fertile: Undetermined Undetermined
    Heterozygotes are fertile: Undetermined Yes
    Age Reproductive Decline: Undetermined Undetermined
    Average litter size
    5-9
    Recommended wean age
    3-4 weeks
    Average Pups Weaned
    5-9

    Order Request Information

    Availability Level

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

    Conditions of Distribution

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    TALEN technology (U.S. Patent No, 8420782 B2)

    Fees

    - Products for this strain are Not Yet Available for Ordering
    - If you register interest in this strain, you will be notified when it becomes available for ordering.
    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.