Strain Name:
C57BL/6N-Tg(Tek-Scarb1)14Arem/Mmjax
Stock Number:
037626-JAX
Citation ID:
RRID:MMRRC_037626-JAX
Other Names:
mTie2-Sr-b1, Tie2-Sr-b1

Gene Information

Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Hyk, Tie2, Cd202b, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21687
Homologene: 397
Tg(Tek-Scarb1)14Arem
Name: transgene insertion 14, Alan Remaley
Synonyms: Tie2-SR-B1
Type: Transgene
Species: Mus musculus (mouse)
Chromosome: unknown
Alteration at locus: Transgenic (random, gene disruption)
Genetic Alterations
Mouse Sr-B1 cDNA gene under control of mouse Tie2 promoter was inserted into mouse genome.
Genotype Determination
ES Cell Line
Not applicable
Phenotype

Homozygous: Mice are viable and fertile

Hemizygous: Mice are viable and fertile

Strain Development
The construct with Tie2-mSr-b1 transgene was injected into the eggs from C57Bl/6J females. Transgenic founder was mated with C57Bl/6NTac mice, so the transgene is on C57Bl/6N background.
Suggested Control Mice
Wild-type littermates or C57BL/6 mice
  • Cardiovascular
  • Metabolism
Donor
Alan Remaley, D.V.M., National Heart, Lung, and Blood Institute (NHLBI).
Primary Reference

Vaisman BL, Ghias M, Demosky SJ, Stonik JA, Amar MJ, Sampson M, Remaley AT. Role of endothelial expression of ABCA1 and SR-BI genes in HDL metabolism, cholesterol trafficking and protection against atherosclerosis. Abstract from AHA Scientific Sessions 2010, Chicago, IL.

Colony and Husbandry Information

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Overall Breeding Performance
Good
NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Hetero/Hemizygotes are fertile: Yes Yes
Age Reproductive Decline: 6 months 6 months
Average litter size
4-6
Recommended wean age
4 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.