Strain Detail Sheet

Strain Name:
C57BL/6J-Zfp318M1Btlr/Mmmh
Stock Number:
038172--TBD-
Citation ID:
RRID:MMRRC_038172--TBD-
Other Names:
Wonton
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Zfp318M1Btlr
Name: zinc finger protein 318; mutation 1, Bruce Beutler
Synonyms: Wonton
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57908
Homologene: 22808
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Genetic Alterations
ENU-induced T to C transition at base pair 46,409,692 (v38) on chromosome 17, or base pair 26,191 in the GenBank genomic region NC_000083 encoding the Zfp318 gene. The mutation corresponds to residue 3,428 in the mRNA sequence NM_207671 within exon 8 of 10 total exons. The mutation results in a tyrosine (Y) to histidine (H) substitution at position 1119 (Y1119H) in the long isoform of the ZFP318 protein.

Strain Description

Phenotype

Homozygous: Mice showed a reduction in IgD mean fluorescence intensity (MFI) on B cells in the peripheral blood.

Heterozygous: Mice showed a reduction in IgD mean fluorescence intensity (MFI) on B cells in the peripheral blood; phenotype was intermediate between wild-type and homozygous Wonton mice.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Zeng M, Murray AR, Beutler B. Record for Wonton. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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