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Strain Name:
C57BL/6J-MtgxR0004Btlr/Mmmh
Stock Number:
038300-MU
Citation ID:
RRID:MMRRC_038300-MU
Other Names:
R0004 (G1), C57BL/6J-MtgxR0004Btlr
Major Collection:

Strain Information

Tgfb1
Name: transforming growth factor, beta 1
Synonyms: TGF-beta 1, Tgfb-1, Tgfb, TGFbeta1, TGF-beta1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21803
Homologene: 540
Sf1
Name: splicing factor 1
Synonyms: WBP4, MZFM, CW17R, Zfp162
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22668
Homologene: 134065
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Hbegf
Name: heparin-binding EGF-like growth factor
Synonyms: HB-EGF, Hegfl, Dtr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15200
VEGA: 18
HGNC: HGNC:3059
Homologene: 1466
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69612
VEGA: 15
Homologene: 32367
Oxr1
Name: oxidation resistance 1
Synonyms: C7B, C7, 2210416C20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170719
VEGA: 15
Homologene: 24993
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Luc7l2
Name: LUC7-like 2 (S. cerevisiae)
Synonyms: CGI-59, CGI-74, 4930471C18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192196
Homologene: 56737
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Akap12
Name: A kinase anchor protein 12
Synonyms: SSeCKS, Tsga12, Srcs5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27054
Homologene: 74571
Cnp
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Synonyms: Cnp-1, CNPase, Cnp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12799
HGNC: HGNC:2158
Homologene: 7672
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, 4632409L19Rik, Inoc1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
Prmt9
Name: protein arginine methyltransferase 9
Synonyms: Prmt10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102182
Homologene: 16298
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Cd207
Name: CD207 antigen
Synonyms: Langerin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 246278
Homologene: 9252
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: 2310008I11Rik, AMPKalpha2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114142
Homologene: 134404
Epha5
Name: Eph receptor A5
Synonyms: Cek7, bsk, Els1, Rek7, Hek7, Ehk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434377
Homologene: 103820
Aff3
Name: AF4/FMR2 family, member 3
Synonyms: LAF-4, 3222402O04Rik, Laf4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16764
HGNC: HGNC:6473
Homologene: 1718
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226470
Homologene: 27795
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Adal
Name: adenosine deaminase-like
Synonyms: 4930578F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75894
Homologene: 13827
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81600
Homologene: 75168
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Ephb2
Name: Eph receptor B2
Synonyms: eteck, Erk, Tyro5, Prkm5, Nuk, Drt, Hek5, Sek3, Qek5, Cek5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Gckr
Name: glucokinase regulatory protein
Synonyms: GKRP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231103
HGNC: HGNC:4196
Homologene: 1139
Ndufb2
Name: NADH:ubiquinone oxidoreductase subunit B2
Synonyms: 8kDa, 1810011O01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68198
HGNC: HGNC:7697
Homologene: 3341
Gm1965
Name: predicted gene 1965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434065
Klra3
Name: killer cell lectin-like receptor, subfamily A, member 3
Synonyms: 5E6, Ly49C, Nk-2, Ly49c, NK-2.1, Nk2.1, Nk2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16634
Homologene: 110821
Klra1
Name: killer cell lectin-like receptor, subfamily A, member 1
Synonyms: Ly49A, Ly49o129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16627
Homologene: 110821
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233103
Homologene: 8795
Scaf1
Name: SR-related CTD-associated factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233208
Or51k1
Name: olfactory receptor family 51 subfamily K member 1
Synonyms: GA_x6K02T2PBJ9-6747143-6746193, MOR12-1, Olfr639
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259088
Homologene: 17497
Zfp791
Name: zinc finger protein 791
Synonyms: EG244556
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244556
Homologene: 27420
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Glce
Name: glucuronyl C5-epimerase
Synonyms: heparan sulfate-glucuronic acid C5-epimerase, Hsepi, C130034A12Rik, 1110017N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93683
Homologene: 14111
Rbm15b
Name: RNA binding motif protein 15B
Synonyms: 1810017N16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109095
Homologene: 8325
Fbxw18
Name: F-box and WD-40 domain protein 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546161
Homologene: 110776
AC159748.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237465
Homologene: 52182
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Colec10
Name: collectin sub-family member 10
Synonyms: CL-L1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239447
VEGA: 15
HGNC: HGNC:2220
Homologene: 31381
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Liph
Name: lipase, member H
Synonyms: PLA1B, mPA-PLA1, C130037N08Rik, Lpdlr, D16Wsu119e, LPDLR
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Tpgs2
Name: tubulin polyglutamylase complex subunit 2
Synonyms: 5730437P09Rik, 5730494M16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66648
Homologene: 9161
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Pcdhb10
Name: protocadherin beta 10
Synonyms: Pcdhb5D, PcdhbJ
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93881
HGNC: HGNC:8690
Homologene: 88834
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Fgfbp3
Name: fibroblast growth factor binding protein 3
Synonyms: 2610306H15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72514
Homologene: 49899
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,269,726 bp
  • A to T, chromosome 1 at 75,557,009 bp
  • A to G, chromosome 1 at 139,442,888 bp
  • T to A, chromosome 2 at 66,687,795 bp
  • G to A, chromosome 2 at 119,382,960 bp
  • T to C, chromosome 2 at 121,152,485 bp
  • T to C, chromosome 2 at 144,564,562 bp
  • G to A, chromosome 3 at 29,979,911 bp
  • G to T, chromosome 3 at 106,129,009 bp
  • T to A, chromosome 3 at 125,570,826 bp
  • C to T, chromosome 4 at 105,047,091 bp
  • T to A, chromosome 4 at 136,657,524 bp
  • A to T, chromosome 5 at 31,297,589 bp
  • T to C, chromosome 5 at 84,331,842 bp
  • A to T, chromosome 5 at 87,671,531 bp
  • A to G, chromosome 5 at 108,161,700 bp
  • A to T, chromosome 5 at 124,726,902 bp
  • A to G, chromosome 6 at 15,197,096 bp
  • A to T, chromosome 6 at 38,589,234 bp
  • C to T, chromosome 6 at 39,596,504 bp
  • G to A, chromosome 6 at 83,674,248 bp
  • A to C, chromosome 6 at 89,146,487 bp
  • A to G, chromosome 6 at 130,323,687 bp
  • A to T, chromosome 6 at 130,372,873 bp
  • T to C, chromosome 7 at 25,692,366 bp
  • A to T, chromosome 7 at 34,256,428 bp
  • T to C, chromosome 7 at 45,007,670 bp
  • C to A, chromosome 7 at 50,560,759 bp
  • A to T, chromosome 7 at 104,012,431 bp
  • A to T, chromosome 8 at 33,317,560 bp
  • A to G, chromosome 8 at 77,555,782 bp
  • G to A, chromosome 8 at 85,110,866 bp
  • C to T, chromosome 9 at 20,347,967 bp
  • T to C, chromosome 9 at 32,151,998 bp
  • A to T, chromosome 9 at 42,345,478 bp
  • A to T, chromosome 9 at 53,453,528 bp
  • T to A, chromosome 9 at 62,068,579 bp
  • T to C, chromosome 9 at 106,884,936 bp
  • T to C, chromosome 9 at 109,701,313 bp
  • A to T, chromosome 10 at 4,353,218 bp
  • A to T, chromosome 10 at 4,353,220 bp
  • A to T, chromosome 10 at 5,443,132 bp
  • A to T, chromosome 10 at 93,574,102 bp
  • G to T, chromosome 10 at 120,108,981 bp
  • A to T, chromosome 10 at 127,541,825 bp
  • T to A, chromosome 11 at 6,515,901 bp
  • A to G, chromosome 11 at 36,023,357 bp
  • T to C, chromosome 11 at 100,576,807 bp
  • T to C, chromosome 11 at 118,060,092 bp
  • A to G, chromosome 12 at 3,596,635 bp
  • T to C, chromosome 13 at 11,665,919 bp
  • T to G, chromosome 13 at 102,702,708 bp
  • A to T, chromosome 14 at 78,514,940 bp
  • G to A, chromosome 15 at 41,820,540 bp
  • G to T, chromosome 15 at 54,410,875 bp
  • A to G, chromosome 15 at 59,367,467 bp
  • T to A, chromosome 15 at 85,818,183 bp
  • A to G, chromosome 15 at 98,520,376 bp
  • T to A, chromosome 16 at 21,984,194 bp
  • A to G, chromosome 17 at 8,981,576 bp
  • A to G, chromosome 18 at 25,158,238 bp
  • A to G, chromosome 18 at 36,507,506 bp
  • T to A, chromosome 18 at 37,145,237 bp
  • T to A, chromosome 18 at 37,411,959 bp
  • T to C, chromosome 18 at 43,305,056 bp
  • C to A, chromosome 19 at 6,374,191 bp
  • A to G, chromosome 19 at 36,918,682 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0004 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038300-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.