Strain Name:
C57BL/6J-MtgxR0031Btlr/Mmmh
Stock Number:
038325-MU
Citation ID:
RRID:MMRRC_038325-MU
Other Names:
R0031 (G1), C57BL/6J-MtgxR0031Btlr
Major Collection:

Gene Information

Lamb1
Name: laminin B1
Synonyms: Lamb1-1, D130003D08Rik, C80098, Lamb-1, C81607
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20348
Homologene: 36201
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Slc25a12
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Synonyms: B230107K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78830
Homologene: 48235
Vps54
Name: VPS54 GARP complex subunit
Synonyms: mSLP8, Vps54l, 5330404P15Rik, wr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245944
Homologene: 5605
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: 2810017C20Rik, E130319N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Ggtb3, Alfy, 2610509D04Rik, Bchs, Bwf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12808
Homologene: 9058
Cmss1
Name: cms small ribosomal subunit 1
Synonyms: 4930572F24Rik, 1110001A06Rik, 2610528E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66497
VEGA: 16
Homologene: 11979
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Fip1l1
Name: FIP1 like 1 (S. cerevisiae)
Synonyms: Rje, 1300019H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66899
Homologene: 136254
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: C330027C09Rik, Cip2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224171
Homologene: 10842
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, PipkIII, Pip5k3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Pwp1
Name: PWP1 homolog, endonuclein
Synonyms: 2610205J09Rik, 2310058A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103136
Homologene: 5129
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Klc1
Name: kinesin light chain 1
Synonyms: Kns2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16593
HGNC: HGNC:6387
Homologene: 4056
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21341
Homologene: 21163
Agr3
Name: anterior gradient 3
Synonyms: LOC380754, E030025L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 403205
Homologene: 45551
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59015
Homologene: 32509
Clstn1
Name: calsyntenin 1
Synonyms: alcadein alpha, 1810034E21Rik, calsyntenin-1, Cst-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 65945
Homologene: 8814
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, mfmi1, flamingo, Adgrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1a, C030033M19Rik, RIM1alpha, RIM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116837
Homologene: 128399
Ormdl1
Name: ORM1-like 1 (S. cerevisiae)
Synonyms: C730042F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227102
Homologene: 41135
Gbgt1
Name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227671
Homologene: 110677
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: Bsep, sister of P-glycoprotein, PFIC2, ABC16, PGY4, Lith1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 96957
Homologene: 11801
Wfdc6b
Name: WAP four-disulfide core domain 6B
Synonyms: Wfdc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433502
Homologene: 79014
1700022I11Rik
Name: RIKEN cDNA 1700022I11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67317
Homologene: 52406
Ncdn
Name: neurochondrin
Synonyms: neurochondrin-2, neurochondrin-1, norbin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26562
Homologene: 8064
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75196
Homologene: 35506
Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
Synonyms: 4921528H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74354
Homologene: 34923
Xpc
Name: xeroderma pigmentosum, complementation group C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22591
Homologene: 3401
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69047
Homologene: 73463
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209012
Homologene: 41205
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216198
Homologene: 17129
Csrp2
Name: cysteine and glycine-rich protein 2
Synonyms: SmLim, Crp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13008
VEGA: 10
HGNC: HGNC:2470
Homologene: 111061
Irak3
Name: interleukin-1 receptor-associated kinase 3
Synonyms: IRAK-M, 4833428C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73914
Homologene: 36215
Gml2
Name: glycosylphosphatidylinositol anchored molecule like 2
Synonyms: HemT, 1700057K19Rik, Hemt1, hematopoietic cell-specific transcript
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15202
HGNC: HGNC:4375
Homologene: 48071
Slc3a1
Name: solute carrier family 3, member 1
Synonyms: D2H, NTAA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20532
VEGA: 17
Homologene: 37289
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: Tent6, Papd1, 0610027A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Plpp6
Name: phospholipid phosphatase 6
Synonyms: Ppapdc2, 4932443D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74411
Homologene: 45228
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 22,296,879 bp
  • A to G, chromosome 1 at 53,299,159 bp
  • T to A, chromosome 1 at 65,215,929 bp
  • A to T, chromosome 1 at 176,756,091 bp
  • T to A, chromosome 2 at 28,498,450 bp
  • A to G, chromosome 2 at 29,176,929 bp
  • G to A, chromosome 2 at 69,285,308 bp
  • C to T, chromosome 2 at 71,333,614 bp
  • A to G, chromosome 2 at 90,717,587 bp
  • A to G, chromosome 2 at 118,715,461 bp
  • A to G, chromosome 2 at 120,999,113 bp
  • A to T, chromosome 2 at 164,613,859 bp
  • T to C, chromosome 3 at 108,413,063 bp
  • A to G, chromosome 3 at 122,803,055 bp
  • A to T, chromosome 4 at 42,973,712 bp
  • A to T, chromosome 4 at 126,750,108 bp
  • G to A, chromosome 4 at 149,634,796 bp
  • T to C, chromosome 5 at 17,694,728 bp
  • T to C, chromosome 5 at 74,557,109 bp
  • A to T, chromosome 5 at 101,889,295 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to A, chromosome 6 at 18,870,008 bp
  • A to T, chromosome 6 at 34,043,496 bp
  • C to T, chromosome 6 at 91,491,226 bp
  • T to A, chromosome 6 at 136,697,999 bp
  • A to T, chromosome 8 at 119,599,090 bp
  • A to T, chromosome 8 at 119,749,062 bp
  • C to T, chromosome 9 at 80,126,243 bp
  • A to G, chromosome 9 at 121,272,982 bp
  • G to T, chromosome 10 at 84,591,140 bp
  • T to C, chromosome 10 at 85,885,896 bp
  • C to T, chromosome 10 at 110,938,740 bp
  • T to A, chromosome 10 at 120,176,320 bp
  • T to C, chromosome 11 at 12,254,945 bp
  • T to C, chromosome 11 at 21,312,899 bp
  • G to A, chromosome 12 at 31,301,156 bp
  • T to C, chromosome 12 at 35,947,591 bp
  • T to C, chromosome 12 at 111,777,033 bp
  • A to G, chromosome 13 at 13,708,156 bp
  • T to C, chromosome 15 at 74,824,276 bp
  • C to T, chromosome 16 at 49,017,373 bp
  • T to G, chromosome 16 at 57,311,249 bp
  • A to G, chromosome 17 at 85,032,846 bp
  • T to A, chromosome 18 at 4,383,244 bp
  • G to T, chromosome 19 at 6,853,783 bp
  • T to A, chromosome 19 at 28,964,843 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0031 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038325-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.