Strain Name:
C57BL/6J-MtgxR0055Btlr/Mmmh
Stock Number:
038349-MU
Citation ID:
RRID:MMRRC_038349-MU
Other Names:
R0055 (G1), C57BL/6J-MtgxR0055Btlr
Major Collection:

Gene Information

Runx1
Name: runt related transcription factor 1
Synonyms: AML1, Pebp2a2, runt domain, alpha subunit 2, Cbfa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12394
Homologene: 1331
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Lin7c
Name: lin-7 homolog C (C. elegans)
Synonyms: LIN-7-C, LIN-7C, Lin7c, MALS-3, Veli3, D2Ertd520e, 9130007B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22343
Homologene: 22649
Cdk7
Name: cyclin-dependent kinase 7
Synonyms: CRK4 PK (CDC2-related-kinase-4 protein kinase), Crk4, Cdkn7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12572
VEGA: 13
HGNC: HGNC:1778
Homologene: 1363
Atp6v1h
Name: ATPase, H+ transporting, lysosomal V1 subunit H
Synonyms: 0710001F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108664
Homologene: 7139
Vsnl1
Name: visinin-like 1
Synonyms: VILIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26950
VEGA: 12
Homologene: 2542
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231670
Homologene: 14145
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, MSK1, 3110005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Rarb
Name: retinoic acid receptor, beta
Synonyms: RARbeta2, RAR beta 2, Hap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218772
VEGA: 14
HGNC: HGNC:9865
Homologene: 68100
Mcm10
Name: minichromosome maintenance 10 replication initiation factor
Synonyms: C330019M07Rik, 2410041F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70024
Homologene: 41275
Eef1aknmt
Name: EEF1A lysine and N-terminal methyltransferase
Synonyms: 5630401D24Rik, Mettl13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71449
Homologene: 32285
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: 7330410C13Rik, A630023E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64706
Homologene: 11224
Cd55
Name: CD55 molecule, decay accelerating factor for complement
Synonyms: Daf-GPI, complement-glycosylphosphatidylinositol, GPI-DAF, Cromer blood group, Daf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13136
HGNC: HGNC:2665
Homologene: 479
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Zfp457
Name: zinc finger protein 457
Synonyms: Rslcan-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 431706
Homologene: 75311
Nefm
Name: neurofilament, medium polypeptide
Synonyms: NF160, Nfm, NF-M, NF165, Nef3, neurofilament-M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18040
HGNC: HGNC:7734
Homologene: 137211
Zdhhc11
Name: zinc finger, DHHC domain containing 11
Synonyms: 4933421L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71164
VEGA: 13
Homologene: 128723
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54403
Homologene: 55776
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, alpha1A, Ccha1a, SCA6, nmf352, smrl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Frmd4b
Name: FERM domain containing 4B
Synonyms: 6030440G05Rik, GRSP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232288
Homologene: 14916
Tbccd1
Name: TBCC domain containing 1
Synonyms: 5730478M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70573
VEGA: 16
Homologene: 32392
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Slc15a3
Name: solute carrier family 15, member 3
Synonyms: cI-1, Ci1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 65221
Homologene: 69222
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72097
Homologene: 19208
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms: Slc25a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22227
Homologene: 22524
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75172
Homologene: 67159
Mybph
Name: myosin binding protein H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53311
HGNC: HGNC:7552
Homologene: 3661
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 207792
Homologene: 19490
Olfr1281
Name: olfactory receptor 1281
Synonyms: GA_x6K02T2Q125-72379864-72380781, MOR248-18, MOR248-14P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257979
Homologene: 73992
Gm12887
Name: predicted gene 12887
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666927
Homologene: 111034
Fzd1
Name: frizzled class receptor 1
Synonyms: FZ-1, Fz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14362
HGNC: HGNC:4038
Homologene: 20750
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: SemD, semaphorin III, sema III, collapsin-1, Semad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20346
Homologene: 31358
Ephx4
Name: epoxide hydrolase 4
Synonyms: LOC384214, Abhd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384214
Homologene: 62402
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232400
Homologene: 45969
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Ccdc61
Name: coiled-coil domain containing 61
Synonyms: LOC232933, C530028I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232933
Homologene: 19256
Olfr615
Name: olfactory receptor 615
Synonyms: GA_x6K02T2PBJ9-6284902-6285843, MOR19-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259084
Homologene: 17494
Olfr670
Name: olfactory receptor 670
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Spn
Name: sialophorin
Synonyms: leukosialin, 3E8 antigen, Cd43, Ly-48, A630014B01Rik, Ly48, Galgp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20737
Homologene: 36108
1700029J07Rik
Name: RIKEN cDNA 1700029J07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69479
Homologene: 45977
Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
Synonyms: Octn2, Lstpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20520
Homologene: 68295
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, CTIP2, B630002E05Rik, Rit1, 9130430L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58208
Homologene: 10974
2210016F16Rik
Name: RIKEN cDNA 2210016F16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70153
Homologene: 13005
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Phf8-ps
Name: PHD finger protein 8, pseudogene
Synonyms: 4921501E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Olfr137
Name: olfactory receptor 137
Synonyms: GA_x6K02T2PSCP-2749525-2748587, MOR256-18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258481
HGNC: HGNC:8261
Homologene: 128084
Morn2
Name: MORN repeat containing 2
Synonyms: Mopt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 378462
VEGA: 17
Homologene: 45667
Slc25a45
Name: solute carrier family 25, member 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107375
Homologene: 76679
Cox8a
Name: cytochrome c oxidase subunit 8A
Synonyms: COX8L, COX VIII-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12868
VEGA: 19
HGNC: HGNC:2294
Homologene: 3006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 5,084,454 bp
  • A to C, chromosome 1 at 37,624,256 bp
  • A to T, chromosome 1 at 66,506,623 bp
  • A to G, chromosome 1 at 118,890,408 bp
  • A to G, chromosome 1 at 130,459,576 bp
  • G to T, chromosome 1 at 134,193,852 bp
  • A to T, chromosome 1 at 155,241,658 bp
  • A to T, chromosome 1 at 162,546,181 bp
  • T to C, chromosome 2 at 4,991,407 bp
  • T to C, chromosome 2 at 60,321,918 bp
  • T to A, chromosome 2 at 109,896,453 bp
  • T to A, chromosome 2 at 111,328,525 bp
  • T to G, chromosome 2 at 181,228,821 bp
  • T to A, chromosome 4 at 121,616,469 bp
  • A to T, chromosome 5 at 4,756,037 bp
  • A to T, chromosome 5 at 13,400,037 bp
  • C to T, chromosome 5 at 21,297,006 bp
  • C to A, chromosome 5 at 48,281,726 bp
  • A to C, chromosome 5 at 89,156,336 bp
  • T to C, chromosome 5 at 107,413,078 bp
  • T to A, chromosome 5 at 118,000,490 bp
  • T to A, chromosome 6 at 89,329,739 bp
  • A to T, chromosome 6 at 97,323,649 bp
  • T to C, chromosome 6 at 128,570,094 bp
  • T to C, chromosome 6 at 135,923,203 bp
  • T to C, chromosome 6 at 146,323,133 bp
  • T to C, chromosome 7 at 18,892,536 bp
  • A to G, chromosome 7 at 103,561,037 bp
  • T to A, chromosome 7 at 104,960,496 bp
  • A to G, chromosome 7 at 109,899,791 bp
  • A to G, chromosome 7 at 127,136,322 bp
  • A to T, chromosome 8 at 45,968,161 bp
  • G to T, chromosome 8 at 83,290,604 bp
  • C to T, chromosome 8 at 84,580,058 bp
  • A to C, chromosome 9 at 86,512,652 bp
  • T to C, chromosome 11 at 53,891,206 bp
  • A to G, chromosome 11 at 79,471,551 bp
  • A to G, chromosome 11 at 83,030,300 bp
  • C to G, chromosome 11 at 103,077,585 bp
  • A to T, chromosome 12 at 11,386,986 bp
  • G to A, chromosome 12 at 100,678,580 bp
  • G to A, chromosome 12 at 107,965,777 bp
  • T to C, chromosome 13 at 58,384,166 bp
  • T to A, chromosome 13 at 67,294,034 bp
  • C to T, chromosome 13 at 73,982,686 bp
  • C to A, chromosome 13 at 100,719,304 bp
  • G to A, chromosome 14 at 16,509,066 bp
  • T to A, chromosome 14 at 68,121,199 bp
  • A to G, chromosome 15 at 83,634,736 bp
  • A to T, chromosome 16 at 9,669,807 bp
  • A to G, chromosome 16 at 22,841,905 bp
  • G to T, chromosome 16 at 92,644,141 bp
  • C to A, chromosome 17 at 27,098,322 bp
  • A to T, chromosome 17 at 33,066,722 bp
  • T to C, chromosome 17 at 38,304,811 bp
  • A to T, chromosome 17 at 80,295,513 bp
  • T to C, chromosome 19 at 5,880,467 bp
  • A to T, chromosome 19 at 7,217,509 bp
  • G to T, chromosome 19 at 10,843,042 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0055 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038349-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.