Strain Name:
C57BL/6J-MtgxR0088Btlr/Mmmh
Stock Number:
038375-MU
Citation ID:
RRID:MMRRC_038375-MU
Other Names:
R0088 (G1), C57BL/6J-MtgxR0088Btlr
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Kif2a
Name: kinesin family member 2A
Synonyms: M-kinesin, Kns2, Kif2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16563
HGNC: HGNC:6318
Homologene: 3320
Rabggtb
Name: Rab geranylgeranyl transferase, b subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19352
HGNC: HGNC:9796
Homologene: 3371
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: 4833427P12Rik, LOC381568, Riz1, KMT8, E330024L24Rik, Riz
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: D15Ertd682e, 2310042P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, repro12, AKAP450, mei2-5, 5730481H23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Carnmt1
Name: carnosine N-methyltransferase 1
Synonyms: 2410127L17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67383
VEGA: 19
Homologene: 6806
Ipo8
Name: importin 8
Synonyms: OM-1, Ranbp8, Om1, C130009K11Rik, 6230418K12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: Death receptor 6, DR6, TR7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Ndel1
Name: nudE neurodevelopment protein 1 like 1
Synonyms: mNudel, 2600006O07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83431
Homologene: 32567
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353188
Homologene: 17021
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: D8Ertd281e, NFAT4, NFATx
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242747
Homologene: 138474
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99326
Homologene: 13003
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: Uncv, cub, Rhbdl6, iRhom2, 4732465I17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217344
Homologene: 11612
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Pklr
Name: pyruvate kinase liver and red blood cell
Synonyms: R-PK, Pk1, Pk-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18770
HGNC: HGNC:9020
Homologene: 37286
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: LERN4, Lrrn6d, A530050P17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320747
Homologene: 18563
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: equatorin, 4930579C15Rik, Afaf, 1700028B15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Mrpl37
Name: mitochondrial ribosomal protein L37
Synonyms: Rpml2, 2300004O14Rik, MRP-L2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56280
Homologene: 9536
Pex10
Name: peroxisomal biogenesis factor 10
Synonyms: LOC230983, peroxisome biogenesis factor 10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 668173
HGNC: HGNC:8851
Homologene: 5671
Sult6b2
Name: sulfotransferase family 6B, member 2
Synonyms: Gm766, LOC330440
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330440
Homologene: 66632
Ngrn
Name: neugrin, neurite outgrowth associated
Synonyms: neurite outgrowth associated protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83485
Homologene: 32330
Bnc1
Name: basonuclin zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: Olfr975, GA_x6K02T2PVTD-33651220-33650288, MOR224-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Tmem266
Name: transmembrane protein 266
Synonyms: AI118078
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244886
Homologene: 17551
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212892
Homologene: 71779
Fbll1
Name: fibrillarin-like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237730
Homologene: 28185
Ttyh2
Name: tweety family member 2
Synonyms: 1110001A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 117160
Homologene: 41882
Cd300e
Name: CD300E molecule
Synonyms: Trem5, Cd300le, Clm2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217306
Homologene: 18145
Fam110c
Name: family with sequence similarity 110, member C
Synonyms: 9030611O19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104943
VEGA: 12
Homologene: 75262
Plekhh1
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Synonyms: D630024D12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211945
VEGA: 12
Homologene: 121939
Serpinb9c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9c
Synonyms: ovalbumin, 3830421J05Rik, NK9, Spi11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20707
HGNC: HGNC:8955
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, EY-cadherin, ENSMUSG00000022188, 1700040A22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239096
VEGA: 14
Homologene: 56951
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
St8sia3
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Synonyms: Siat8c, ST8SiaIII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20451
Homologene: 8285
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 40,365,053 bp
  • T to C, chromosome 1 at 127,976,462 bp
  • C to A, chromosome 2 at 33,034,798 bp
  • A to G, chromosome 3 at 89,141,908 bp
  • A to G, chromosome 3 at 94,402,033 bp
  • C to A, chromosome 3 at 153,908,830 bp
  • T to C, chromosome 4 at 94,919,990 bp
  • A to G, chromosome 4 at 107,064,424 bp
  • A to G, chromosome 4 at 139,440,814 bp
  • G to A, chromosome 4 at 143,134,954 bp
  • A to T, chromosome 4 at 147,828,399 bp
  • A to T, chromosome 4 at 155,070,498 bp
  • C to A, chromosome 5 at 3,961,946 bp
  • T to C, chromosome 6 at 17,571,599 bp
  • T to C, chromosome 6 at 121,473,289 bp
  • T to A, chromosome 6 at 142,797,949 bp
  • C to T, chromosome 6 at 146,241,185 bp
  • T to C, chromosome 6 at 148,801,936 bp
  • T to C, chromosome 7 at 80,264,455 bp
  • T to G, chromosome 7 at 81,978,498 bp
  • T to C, chromosome 8 at 24,914,067 bp
  • T to G, chromosome 8 at 85,942,391 bp
  • T to A, chromosome 8 at 106,127,942 bp
  • A to G, chromosome 9 at 39,950,375 bp
  • A to G, chromosome 9 at 55,437,329 bp
  • T to C, chromosome 9 at 95,795,768 bp
  • A to G, chromosome 9 at 118,478,673 bp
  • A to G, chromosome 10 at 33,909,353 bp
  • C to A, chromosome 11 at 35,798,140 bp
  • A to C, chromosome 11 at 68,833,420 bp
  • T to C, chromosome 11 at 113,827,086 bp
  • G to T, chromosome 11 at 114,690,255 bp
  • G to A, chromosome 11 at 115,055,239 bp
  • A to G, chromosome 11 at 116,602,178 bp
  • T to C, chromosome 12 at 31,075,218 bp
  • G to T, chromosome 12 at 52,516,548 bp
  • A to C, chromosome 12 at 79,055,366 bp
  • A to C, chromosome 13 at 33,150,394 bp
  • G to A, chromosome 13 at 106,975,432 bp
  • T to C, chromosome 14 at 54,633,714 bp
  • A to T, chromosome 15 at 97,683,814 bp
  • T to C, chromosome 17 at 14,681,701 bp
  • C to T, chromosome 17 at 43,038,213 bp
  • T to A, chromosome 18 at 64,266,985 bp
  • T to A, chromosome 19 at 18,677,853 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0088 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038375-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.