Strain Name:
C57BL/6J-MtgxR0088Btlr/Mmmh
Stock Number:
038375-MU
Citation ID:
RRID:MMRRC_038375-MU
Other Names:
R0088 (G1), C57BL/6J-MtgxR0088Btlr
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Kif2a
Name: kinesin family member 2A
Synonyms: Kns2, Kif2, M-kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16563
HGNC: HGNC:6318
Homologene: 3320
Rabggtb
Name: Rab geranylgeranyl transferase, b subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19352
HGNC: HGNC:9796
Homologene: 3371
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226409
Homologene: 32770
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: Riz, Riz1, LOC381568, E330024L24Rik, 4833427P12Rik, KMT8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: 2310042P20Rik, D15Ertd682e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Carnmt1
Name: carnosine N-methyltransferase 1
Synonyms: 2410127L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67383
VEGA: 19
Homologene: 6806
Ipo8
Name: importin 8
Synonyms: OM-1, 6230418K12Rik, Om1, C130009K11Rik, Ranbp8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: DR6, Death receptor 6, TR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: BRAG3, synarfGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243621
Homologene: 46091
Ndel1
Name: nudE neurodevelopment protein 1 like 1
Synonyms: 2600006O07Rik, mNudel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83431
Homologene: 32567
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353188
Homologene: 17021
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: NFAT4, NFATx, D8Ertd281e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242747
Homologene: 138474
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99326
Homologene: 13003
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: 4732465I17Rik, Rhbdl6, iRhom2, cub, Uncv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217344
Homologene: 11612
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Pklr
Name: pyruvate kinase liver and red blood cell
Synonyms: Pk-1, Pk1, R-PK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18770
HGNC: HGNC:9020
Homologene: 37286
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, Lrrn6d, LERN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320747
Homologene: 18563
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: 1700028B15Rik, Afaf, equatorin, 4930579C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Mrpl37
Name: mitochondrial ribosomal protein L37
Synonyms: MRP-L2, Rpml2, 2300004O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56280
Homologene: 9536
Pex10
Name: peroxisomal biogenesis factor 10
Synonyms: LOC230983, peroxisome biogenesis factor 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 668173
HGNC: HGNC:8851
Homologene: 5671
Sult6b2
Name: sulfotransferase family 6B, member 2
Synonyms: LOC330440, Gm766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330440
Homologene: 66632
Ngrn
Name: neugrin, neurite outgrowth associated
Synonyms: neurite outgrowth associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83485
Homologene: 32330
Bnc1
Name: basonuclin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: GA_x6K02T2PVTD-33651220-33650288, MOR224-2, Olfr975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Tmem266
Name: transmembrane protein 266
Synonyms: AI118078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244886
Homologene: 17551
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212892
Homologene: 71779
Fbll1
Name: fibrillarin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237730
Homologene: 28185
Ttyh2
Name: tweety family member 2
Synonyms: 1110001A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 117160
Homologene: 41882
Cd300e
Name: CD300E molecule
Synonyms: Clm2, Trem5, Cd300le
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217306
Homologene: 18145
Fam110c
Name: family with sequence similarity 110, member C
Synonyms: 9030611O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104943
VEGA: 12
Homologene: 75262
Plekhh1
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Synonyms: D630024D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211945
VEGA: 12
Homologene: 121939
Serpinb9c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9c
Synonyms: 3830421J05Rik, ovalbumin, Spi11, NK9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20707
HGNC: HGNC:8955
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, EY-cadherin, 1700040A22Rik, ENSMUSG00000022188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239096
VEGA: 14
Homologene: 56951
Thbs2
Name: thrombospondin 2
Synonyms: TSP2, Thbs-2, Thrombospondin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
St8sia3
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Synonyms: ST8SiaIII, Siat8c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20451
Homologene: 8285
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 40,365,053 bp
  • T to C, chromosome 1 at 127,976,462 bp
  • C to A, chromosome 2 at 33,034,798 bp
  • A to G, chromosome 3 at 89,141,908 bp
  • A to G, chromosome 3 at 94,402,033 bp
  • C to A, chromosome 3 at 153,908,830 bp
  • T to C, chromosome 4 at 94,919,990 bp
  • A to G, chromosome 4 at 107,064,424 bp
  • A to G, chromosome 4 at 139,440,814 bp
  • G to A, chromosome 4 at 143,134,954 bp
  • A to T, chromosome 4 at 147,828,399 bp
  • A to T, chromosome 4 at 155,070,498 bp
  • C to A, chromosome 5 at 3,961,946 bp
  • T to C, chromosome 6 at 17,571,599 bp
  • T to C, chromosome 6 at 121,473,289 bp
  • T to A, chromosome 6 at 142,797,949 bp
  • C to T, chromosome 6 at 146,241,185 bp
  • T to C, chromosome 6 at 148,801,936 bp
  • T to C, chromosome 7 at 80,264,455 bp
  • T to G, chromosome 7 at 81,978,498 bp
  • T to C, chromosome 8 at 24,914,067 bp
  • T to G, chromosome 8 at 85,942,391 bp
  • T to A, chromosome 8 at 106,127,942 bp
  • A to G, chromosome 9 at 39,950,375 bp
  • A to G, chromosome 9 at 55,437,329 bp
  • T to C, chromosome 9 at 95,795,768 bp
  • A to G, chromosome 9 at 118,478,673 bp
  • A to G, chromosome 10 at 33,909,353 bp
  • C to A, chromosome 11 at 35,798,140 bp
  • A to C, chromosome 11 at 68,833,420 bp
  • T to C, chromosome 11 at 113,827,086 bp
  • G to T, chromosome 11 at 114,690,255 bp
  • G to A, chromosome 11 at 115,055,239 bp
  • A to G, chromosome 11 at 116,602,178 bp
  • T to C, chromosome 12 at 31,075,218 bp
  • G to T, chromosome 12 at 52,516,548 bp
  • A to C, chromosome 12 at 79,055,366 bp
  • A to C, chromosome 13 at 33,150,394 bp
  • G to A, chromosome 13 at 106,975,432 bp
  • T to C, chromosome 14 at 54,633,714 bp
  • A to T, chromosome 15 at 97,683,814 bp
  • T to C, chromosome 17 at 14,681,701 bp
  • C to T, chromosome 17 at 43,038,213 bp
  • T to A, chromosome 18 at 64,266,985 bp
  • T to A, chromosome 19 at 18,677,853 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0088 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038375-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.