Strain Name:
C57BL/6J-MtgxR0108Btlr/Mmmh
Stock Number:
038394-MU
Citation ID:
RRID:MMRRC_038394-MU
Other Names:
R0108 (G1), C57BL/6J-MtgxR0108Btlr
Major Collection:

Strain Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: my, b2b1562Clo, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: Mrf2alpha, 5430435G07Rik, Desrt, Mrf2, Mrf2beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: 90kDa, Rsk3, p90rsk, Rps6ka-rs1, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: p66beta, C430014D17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: AATYK2, KPI-2, cprk, KPI2, A330101P12Rik, BREK, 2900041G10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231876
Homologene: 8948
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269003
VEGA: 18
Homologene: 11577
Lonp2
Name: lon peptidase 2, peroxisomal
Synonyms: 1300002A08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66887
Homologene: 12050
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: 1810010K08Rik, ZTL1, Znt5, ZnT-5, Zntl1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: RPTPJ, CD148, DEP-1, Scc1, Byp, Scc-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Atg4c
Name: autophagy related 4C, cysteine peptidase
Synonyms: autophagin 3, Apg4-C, Apg4c, Autl1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242557
Homologene: 56296
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Jph4
Name: junctophilin 4
Synonyms: 9330157P13Rik, JPHL1, JP-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319984
Homologene: 13034
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: C330002D13Rik, Coh1, 1810042B05Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Zfand3
Name: zinc finger, AN1-type domain 3
Synonyms: Tex27, TEG-27
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21769
VEGA: 17
Homologene: 11077
Nfyb
Name: nuclear transcription factor-Y beta
Synonyms: Cbf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18045
HGNC: HGNC:7805
Homologene: 38149
Helq
Name: helicase, POLQ-like
Synonyms: Hel308, D430018E21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 191578
Homologene: 14667
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: C130096N06Rik, D130005J21Rik, Girdin, HkRP1, A430106J12Rik, C330012F17Rik, GIV
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108686
Homologene: 41180
Plekho2
Name: pleckstrin homology domain containing, family O member 2
Synonyms: Plekhq1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102595
VEGA: 9
Homologene: 11870
Ackr4
Name: atypical chemokine receptor 4
Synonyms: CCBP2, Ccrl1, CCR11, PPR1, VSHK1, CCX-CKR, A630091E18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: SPACR, A930015H12Rik, IMP150
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: Gm3812, LOC100042382, Liprin-alpha4, 1110008G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546981
Homologene: 115466
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
Plcl1
Name: phospholipase C-like 1
Synonyms: C230017K02Rik, PRIP-1, PLC-L
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231238
Homologene: 9054
Sec11a
Name: SEC11 homolog A, signal peptidase complex subunit
Synonyms: Sec11l1, 18kDa, 1810012E07Rik, Spc18, sid2895
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56529
Homologene: 55536
Tm6sf1
Name: transmembrane 6 superfamily member 1
Synonyms: C630016D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 107769
Homologene: 11305
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Shroom1
Name: shroom family member 1
Synonyms: Shrm1, 1300007L22Rik, Apx
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71774
Homologene: 12411
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM25H2, SM2SH2, Fbw10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Itgb7
Name: integrin beta 7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16421
HGNC: HGNC:6162
Homologene: 20247
Or10q1b
Name: olfactory receptor family 10 subfamily Q member 1B
Synonyms: Olfr1491, GA_x6K02T2RE5P-4037809-4038768, MOR266-8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258342
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: F830007N14Rik, Card4, Nlrc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107607
Homologene: 4440
Or2bd2
Name: olfactory receptor family 2 subfamily BD member 2
Synonyms: Olfr1344, MOR124-1, 4930415J05Rik, GA_x6K02T2QGBW-3169916-3170881
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257882
Gm136
Name: predicted gene 136
Synonyms: LOC214568
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214568
Homologene: 79759
Tas2r120
Name: taste receptor, type 2, member 120
Synonyms: mGR20, mt2r47, T2R20, Tas2r20
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387348
Homologene: 135705
Pstpip1
Name: proline-serine-threonine phosphatase-interacting protein 1
Synonyms: def-2, CD2BP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19200
HGNC: HGNC:9580
Homologene: 37867
Syt16
Name: synaptotagmin XVI
Synonyms: syt14r, Strep14, Syt14l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238266
VEGA: 12
Homologene: 12902
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 55,697,939 bp
  • G to T, chromosome 1 at 74,679,769 bp
  • A to T, chromosome 1 at 134,324,217 bp
  • A to T, chromosome 2 at 90,469,777 bp
  • G to T, chromosome 3 at 53,647,961 bp
  • A to G, chromosome 3 at 90,189,575 bp
  • T to A, chromosome 3 at 90,357,943 bp
  • T to C, chromosome 3 at 109,851,755 bp
  • G to T, chromosome 4 at 34,746,593 bp
  • C to T, chromosome 4 at 81,381,805 bp
  • C to T, chromosome 4 at 99,221,440 bp
  • C to T, chromosome 5 at 53,137,902 bp
  • C to A, chromosome 5 at 100,768,368 bp
  • C to T, chromosome 5 at 144,174,285 bp
  • A to G, chromosome 6 at 54,943,749 bp
  • T to A, chromosome 6 at 132,657,846 bp
  • C to T, chromosome 7 at 6,440,400 bp
  • A to G, chromosome 7 at 44,634,519 bp
  • A to G, chromosome 7 at 80,935,039 bp
  • G to A, chromosome 7 at 81,865,345 bp
  • G to A, chromosome 7 at 86,165,658 bp
  • G to A, chromosome 8 at 86,716,355 bp
  • A to G, chromosome 9 at 56,127,766 bp
  • A to T, chromosome 9 at 65,559,423 bp
  • T to C, chromosome 9 at 80,322,848 bp
  • T to A, chromosome 9 at 104,099,188 bp
  • A to T, chromosome 9 at 122,775,609 bp
  • T to C, chromosome 10 at 68,278,729 bp
  • G to A, chromosome 10 at 82,755,002 bp
  • T to A, chromosome 11 at 29,503,463 bp
  • T to C, chromosome 11 at 53,466,937 bp
  • T to C, chromosome 11 at 59,022,374 bp
  • A to G, chromosome 11 at 62,877,061 bp
  • T to C, chromosome 11 at 116,220,876 bp
  • A to G, chromosome 12 at 40,127,987 bp
  • T to A, chromosome 12 at 71,177,918 bp
  • T to C, chromosome 12 at 74,229,480 bp
  • A to T, chromosome 13 at 68,651,935 bp
  • A to G, chromosome 13 at 81,578,404 bp
  • G to T, chromosome 13 at 100,803,400 bp
  • T to C, chromosome 14 at 55,109,300 bp
  • T to C, chromosome 15 at 11,311,098 bp
  • A to G, chromosome 15 at 35,572,119 bp
  • C to T, chromosome 15 at 102,223,482 bp
  • G to A, chromosome 17 at 7,296,043 bp
  • A to G, chromosome 17 at 30,135,398 bp
  • C to A, chromosome 18 at 31,666,329 bp
  • T to A, chromosome 18 at 36,998,756 bp
  • A to T, chromosome 19 at 13,705,678 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0108 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038394-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.