Strain Name:
C57BL/6J-MtgxR0108Btlr/Mmmh
Stock Number:
038394-MU
Citation ID:
RRID:MMRRC_038394-MU
Other Names:
R0108 (G1), C57BL/6J-MtgxR0108Btlr
Major Collection:

Gene Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: b2b1562Clo, my, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242022
Homologene: 18454
Arid5b
Name: AT rich interactive domain 5B (MRF1-like)
Synonyms: Desrt, Mrf2beta, Mrf2, Mrf2alpha, 5430435G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71371
VEGA: 10
Homologene: 45872
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77595
Homologene: 28122
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: D17Wsu134e, Rsk3, p90rsk, pp90rsk, 90kDa, Rps6ka-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20112
VEGA: 17
Homologene: 100680
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: C430014D17Rik, p66beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229542
Homologene: 32484
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, AATYK2, KPI-2, cprk, KPI2, A330101P12Rik, BREK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231876
Homologene: 8948
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 269003
VEGA: 18
Homologene: 11577
Lonp2
Name: lon peptidase 2, peroxisomal
Synonyms: 1300002A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66887
Homologene: 12050
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67534
Homologene: 8764
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: ZnT-5, Znt5, Zntl1, 1810010K08Rik, ZTL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69048
VEGA: 13
Homologene: 41503
Ptprj
Name: protein tyrosine phosphatase, receptor type, J
Synonyms: Byp, CD148, DEP-1, RPTPJ, Scc-1, Scc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Atg4c
Name: autophagy related 4C, cysteine peptidase
Synonyms: Apg4-C, autophagin 3, Apg4c, Autl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242557
Homologene: 56296
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71960
Homologene: 23480
Jph4
Name: junctophilin 4
Synonyms: 9330157P13Rik, JPHL1, JP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 319984
Homologene: 13034
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 2310042E16Rik, Coh1, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Zfand3
Name: zinc finger, AN1-type domain 3
Synonyms: TEG-27, Tex27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 21769
VEGA: 17
Homologene: 11077
Nfyb
Name: nuclear transcription factor-Y beta
Synonyms: Cbf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18045
HGNC: HGNC:7805
Homologene: 38149
Helq
Name: helicase, POLQ-like
Synonyms: D430018E21Rik, Hel308
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 191578
Homologene: 14667
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239337
VEGA: 15
Homologene: 12808
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80883
Homologene: 8949
Mpdz
Name: multiple PDZ domain protein
Synonyms: B930003D11Rik, MUPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76967
Homologene: 8839
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: D130005J21Rik, GIV, A430106J12Rik, C330012F17Rik, Girdin, HkRP1, C130096N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108686
Homologene: 41180
Plekho2
Name: pleckstrin homology domain containing, family O member 2
Synonyms: Plekhq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 102595
VEGA: 9
Homologene: 11870
Ackr4
Name: atypical chemokine receptor 4
Synonyms: PPR1, Ccrl1, A630091E18Rik, VSHK1, CCX-CKR, CCR11, CCBP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20259
Homologene: 36296
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mgr1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: A930015H12Rik, SPACR, IMP150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: Gm3812, Liprin-alpha4, 1110008G13Rik, LOC100042382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 546981
Homologene: 115466
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
Plcl1
Name: phospholipase C-like 1
Synonyms: PRIP-1, PLC-L, C230017K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231238
Homologene: 9054
Sec11a
Name: SEC11 homolog A, signal peptidase complex subunit
Synonyms: Sec11l1, 1810012E07Rik, sid2895, 18kDa, Spc18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56529
Homologene: 55536
Tm6sf1
Name: transmembrane 6 superfamily member 1
Synonyms: C630016D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 107769
Homologene: 11305
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 671232
VEGA: 9
Homologene: 19835
Shroom1
Name: shroom family member 1
Synonyms: Apx, 1300007L22Rik, Shrm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71774
Homologene: 12411
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM2SH2, SM25H2, Fbw10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 213980
Homologene: 32757
Itgb7
Name: integrin beta 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16421
HGNC: HGNC:6162
Homologene: 20247
Olfr1491
Name: olfactory receptor 1491
Synonyms: MOR266-8, GA_x6K02T2RE5P-4037809-4038768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258342
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Nlrc1, Card4, F830007N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 107607
Homologene: 4440
Olfr1344
Name: olfactory receptor 1344
Synonyms: MOR124-1, GA_x6K02T2QGBW-3169916-3170881, 4930415J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 257882
Gm136
Name: predicted gene 136
Synonyms: LOC214568
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214568
Homologene: 79759
Tas2r120
Name: taste receptor, type 2, member 120
Synonyms: mt2r47, T2R20, Tas2r20, mGR20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387348
Homologene: 135705
Pstpip1
Name: proline-serine-threonine phosphatase-interacting protein 1
Synonyms: def-2, CD2BP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19200
HGNC: HGNC:9580
Homologene: 37867
Syt16
Name: synaptotagmin XVI
Synonyms: syt14r, Syt14l, Strep14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238266
VEGA: 12
Homologene: 12902
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 55,697,939 bp
  • G to T, chromosome 1 at 74,679,769 bp
  • A to T, chromosome 1 at 134,324,217 bp
  • A to T, chromosome 2 at 90,469,777 bp
  • G to T, chromosome 3 at 53,647,961 bp
  • A to G, chromosome 3 at 90,189,575 bp
  • T to A, chromosome 3 at 90,357,943 bp
  • T to C, chromosome 3 at 109,851,755 bp
  • G to T, chromosome 4 at 34,746,593 bp
  • C to T, chromosome 4 at 81,381,805 bp
  • C to T, chromosome 4 at 99,221,440 bp
  • C to T, chromosome 5 at 53,137,902 bp
  • C to A, chromosome 5 at 100,768,368 bp
  • C to T, chromosome 5 at 144,174,285 bp
  • A to G, chromosome 6 at 54,943,749 bp
  • T to A, chromosome 6 at 132,657,846 bp
  • C to T, chromosome 7 at 6,440,400 bp
  • A to G, chromosome 7 at 44,634,519 bp
  • A to G, chromosome 7 at 80,935,039 bp
  • G to A, chromosome 7 at 81,865,345 bp
  • G to A, chromosome 7 at 86,165,658 bp
  • G to A, chromosome 8 at 86,716,355 bp
  • A to G, chromosome 9 at 56,127,766 bp
  • A to T, chromosome 9 at 65,559,423 bp
  • T to C, chromosome 9 at 80,322,848 bp
  • T to A, chromosome 9 at 104,099,188 bp
  • A to T, chromosome 9 at 122,775,609 bp
  • T to C, chromosome 10 at 68,278,729 bp
  • G to A, chromosome 10 at 82,755,002 bp
  • T to A, chromosome 11 at 29,503,463 bp
  • T to C, chromosome 11 at 53,466,937 bp
  • T to C, chromosome 11 at 59,022,374 bp
  • A to G, chromosome 11 at 62,877,061 bp
  • T to C, chromosome 11 at 116,220,876 bp
  • A to G, chromosome 12 at 40,127,987 bp
  • T to A, chromosome 12 at 71,177,918 bp
  • T to C, chromosome 12 at 74,229,480 bp
  • A to T, chromosome 13 at 68,651,935 bp
  • A to G, chromosome 13 at 81,578,404 bp
  • G to T, chromosome 13 at 100,803,400 bp
  • T to C, chromosome 14 at 55,109,300 bp
  • T to C, chromosome 15 at 11,311,098 bp
  • A to G, chromosome 15 at 35,572,119 bp
  • C to T, chromosome 15 at 102,223,482 bp
  • G to A, chromosome 17 at 7,296,043 bp
  • A to G, chromosome 17 at 30,135,398 bp
  • C to A, chromosome 18 at 31,666,329 bp
  • T to A, chromosome 18 at 36,998,756 bp
  • A to T, chromosome 19 at 13,705,678 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0108 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038394-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.