Strain Name:
C57BL/6J-MtgxR0183Btlr/Mmmh
Stock Number:
038448-MU
Citation ID:
RRID:MMRRC_038448-MU
Other Names:
R0183 (G1), C57BL/6J-MtgxR0183Btlr
Major Collection:

Gene Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: Trb, 5830465M17Rik, 4933415H02Rik, Che-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56321
Homologene: 40811
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhcb, MYH-beta/slow, betaMHC, beta-MHC, MyHC-I, Myhc-b, B-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9130004I02Rik, 9430095K15Rik, 9030421L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, IMP2, C330012H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Mkks
Name: McKusick-Kaufman syndrome
Synonyms: Bbs6, 1300013E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59030
HGNC: HGNC:7108
Homologene: 10318
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231326
Homologene: 71711
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MAPKKK4, Mekk4, RP17, D17Rp17e, Tas, D17Rp17, MTK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Eef1e1
Name: eukaryotic translation elongation factor 1 epsilon 1
Synonyms: 1110003A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66143
VEGA: 13
HGNC: HGNC:3212
Homologene: 3161
Tcf12
Name: transcription factor 12
Synonyms: HEB, HTF-4, HEBAlt, ALF1, ME1, REB, bHLHb20, HTF4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21406
Homologene: 40774
Ranbp9
Name: RAN binding protein 9
Synonyms: RanBPM, IBAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56705
VEGA: 13
Homologene: 38057
Faf1
Name: Fas-associated factor 1
Synonyms: Dffrx, Fam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21848
Homologene: 20830
Gtpbp4
Name: GTP binding protein 4
Synonyms: Crfg, 2610028C09Rik, Nog1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69237
VEGA: 13
Homologene: 7100
Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Synonyms: hcp, Ptp1C, Hcph, SHP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15170
HGNC: HGNC:9658
Homologene: 56589
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAFII150, 4732460C16Rik, TAF2B, CIF150, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: curt, 4932416N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74374
Homologene: 71019
Fosb
Name: FBJ osteosarcoma oncogene B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14282
HGNC: HGNC:3797
Homologene: 31403
Prkcq
Name: protein kinase C, theta
Synonyms: Pkcq, PKC-theta, A130035A12Rik, PKC-0, PKCtheta, PKC theta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Bcl2
Name: B cell leukemia/lymphoma 2
Synonyms: C430015F12Rik, D830018M01Rik, Bcl-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12043
HGNC: HGNC:990
Homologene: 527
Oprl1
Name: opioid receptor-like 1
Synonyms: nociceptin/ orphaninFQ receptor, morc, NOP, N/OFQ receptor, ORL1, MOR-C, XOR1, LC132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18389
HGNC: HGNC:8155
Homologene: 22609
Ass1
Name: argininosuccinate synthetase 1
Synonyms: fold, Ass-1, ASS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Acf1, Wcrf180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms: 2900057D21Rik, 7330406P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72993
Homologene: 32143
Eaf1
Name: ELL associated factor 1
Synonyms: 4933403C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74427
VEGA: 14
Homologene: 12561
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: LOC381605, PARIS1, A630005A06Rik, PARIS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381605
Homologene: 10190
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: Hapip, LOC224126, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Pink1
Name: PTEN induced putative kinase 1
Synonyms: brpk, 1190006F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68943
Homologene: 32672
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: Ptpri, PTPL1, PTP-BL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Epha3
Name: Eph receptor A3
Synonyms: Cek4, Hek, Tyro4, Mek4, Hek4, End3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Cyp2c70
Name: cytochrome P450, family 2, subfamily c, polypeptide 70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226105
Homologene: 120027
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: 1110033O10Rik, 8430411H09Rik, Saps2, Pp6r2, B230107H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 277978
Homologene: 18629
Gas2l2
Name: growth arrest-specific 2 like 2
Synonyms: OTTMUSG00000000934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237891
Homologene: 16409
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: MaxiK, 5730414M22Rik, BKCa, mSlo1, Slo1, BK channel alpha subunit, Slo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Phf19
Name: PHD finger protein 19
Synonyms: 3321402G02Rik, 3110009G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74016
Homologene: 12524
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Nmrk1
Name: nicotinamide riboside kinase 1
Synonyms: D630020N23Rik, BC016495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225994
Homologene: 6787
Amer3
Name: APC membrane recruitment 3
Synonyms: Fam123c, 9430069J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211383
Homologene: 51888
Olfr1046
Name: olfactory receptor 1046
Synonyms: MOR194-1, GA_x6K02T2Q125-47692494-47691544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258575
Homologene: 17301
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: Ccp2, Ccp2, A430081C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271813
Homologene: 11715
Cenpb
Name: centromere protein B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12616
HGNC: HGNC:1852
Homologene: 1370
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Ptpre
Name: protein tyrosine phosphatase, receptor type, E
Synonyms: PTPepsilon, RPTPepsilon, PTPe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Mmp19
Name: matrix metallopeptidase 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58223
VEGA: 10
HGNC: HGNC:7165
Homologene: 1820
Sec14l3
Name: SEC14-like lipid binding 3
Synonyms: 1110069O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380683
Homologene: 24848
Olfr1380
Name: olfactory receptor 1380
Synonyms: GA_x6K02T2QP88-5871967-5871032, MOR256-66_i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 404336
Homologene: 72463
Mrps23
Name: mitochondrial ribosomal protein S23
Synonyms: 2310047I09Rik, Rpms23, D11Bwg1153e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 64656
Homologene: 41101
Card14
Name: caspase recruitment domain family, member 14
Synonyms: Bimp2, CARMA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170720
Homologene: 11469
Jkamp
Name: JNK1/MAPK8-associated membrane protein
Synonyms: 1200003C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104771
Homologene: 9524
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: 1700055P21Rik, Esdn, CLCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73379
Homologene: 12499
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: 5630400D21Rik, beta-1, 6-N-acetylglucosaminyltransferase, IGnT, C2 GlcNAcT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,587,757 bp
  • G to A, chromosome 1 at 106,712,562 bp
  • T to C, chromosome 2 at 11,253,162 bp
  • A to T, chromosome 2 at 31,514,819 bp
  • T to C, chromosome 2 at 34,911,202 bp
  • T to A, chromosome 2 at 86,216,829 bp
  • T to A, chromosome 2 at 90,783,676 bp
  • T to C, chromosome 2 at 131,178,453 bp
  • G to A, chromosome 2 at 136,880,686 bp
  • T to A, chromosome 2 at 181,715,961 bp
  • A to C, chromosome 3 at 76,322,272 bp
  • A to G, chromosome 4 at 46,629,865 bp
  • A to G, chromosome 4 at 109,935,610 bp
  • T to G, chromosome 4 at 138,314,179 bp
  • C to T, chromosome 5 at 76,886,235 bp
  • T to C, chromosome 5 at 103,516,408 bp
  • T to A, chromosome 6 at 37,943,480 bp
  • C to T, chromosome 6 at 73,082,923 bp
  • A to G, chromosome 6 at 124,728,951 bp
  • G to A, chromosome 7 at 7,295,091 bp
  • A to G, chromosome 7 at 19,307,385 bp
  • A to G, chromosome 7 at 28,898,264 bp
  • G to T, chromosome 7 at 135,669,845 bp
  • T to C, chromosome 8 at 13,133,790 bp
  • C to A, chromosome 8 at 105,295,300 bp
  • A to T, chromosome 9 at 71,917,027 bp
  • A to G, chromosome 10 at 18,165,475 bp
  • A to G, chromosome 10 at 78,791,233 bp
  • T to A, chromosome 10 at 126,010,192 bp
  • C to T, chromosome 10 at 128,799,003 bp
  • C to T, chromosome 11 at 4,075,547 bp
  • A to G, chromosome 11 at 49,564,848 bp
  • T to A, chromosome 11 at 83,429,056 bp
  • A to T, chromosome 11 at 84,510,425 bp
  • A to G, chromosome 11 at 88,210,154 bp
  • C to T, chromosome 11 at 119,326,698 bp
  • T to A, chromosome 12 at 54,911,387 bp
  • T to C, chromosome 12 at 72,094,035 bp
  • A to G, chromosome 13 at 8,974,961 bp
  • C to T, chromosome 13 at 38,656,186 bp
  • T to C, chromosome 13 at 43,425,123 bp
  • A to T, chromosome 14 at 23,508,052 bp
  • A to T, chromosome 14 at 26,962,854 bp
  • T to A, chromosome 14 at 31,495,315 bp
  • T to C, chromosome 14 at 54,978,876 bp
  • T to A, chromosome 14 at 62,419,140 bp
  • A to T, chromosome 15 at 9,716,359 bp
  • T to A, chromosome 15 at 55,055,790 bp
  • G to A, chromosome 15 at 89,285,787 bp
  • T to C, chromosome 16 at 10,560,022 bp
  • A to T, chromosome 16 at 22,078,730 bp
  • A to T, chromosome 16 at 34,171,379 bp
  • A to G, chromosome 16 at 58,445,359 bp
  • G to A, chromosome 16 at 63,595,746 bp
  • A to G, chromosome 17 at 12,235,128 bp
  • C to T, chromosome 19 at 17,329,117 bp
  • A to G, chromosome 19 at 18,636,150 bp
  • A to T, chromosome 19 at 33,749,551 bp
  • C to A, chromosome 19 at 40,187,086 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038448-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.