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Strain Name:
C57BL/6J-MtgxR0183Btlr/Mmmh
Stock Number:
038448-MU
Citation ID:
RRID:MMRRC_038448-MU
Other Names:
R0183 (G1), C57BL/6J-MtgxR0183Btlr
Major Collection:

Strain Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 4933415H02Rik, Trb, 5830465M17Rik, Che-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56321
Homologene: 40811
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Mkks
Name: McKusick-Kaufman syndrome
Synonyms: 1300013E18Rik, Bbs6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59030
HGNC: HGNC:7108
Homologene: 10318
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,587,757 bp
  • G to A, chromosome 1 at 106,712,562 bp
  • T to C, chromosome 2 at 11,253,162 bp
  • A to T, chromosome 2 at 31,514,819 bp
  • T to C, chromosome 2 at 34,911,202 bp
  • T to A, chromosome 2 at 86,216,829 bp
  • T to A, chromosome 2 at 90,783,676 bp
  • T to C, chromosome 2 at 131,178,453 bp
  • G to A, chromosome 2 at 136,880,686 bp
  • T to A, chromosome 2 at 181,715,961 bp
  • A to C, chromosome 3 at 76,322,272 bp
  • A to G, chromosome 4 at 46,629,865 bp
  • A to G, chromosome 4 at 109,935,610 bp
  • T to G, chromosome 4 at 138,314,179 bp
  • C to T, chromosome 5 at 76,886,235 bp
  • T to C, chromosome 5 at 103,516,408 bp
  • T to A, chromosome 6 at 37,943,480 bp
  • C to T, chromosome 6 at 73,082,923 bp
  • A to G, chromosome 6 at 124,728,951 bp
  • G to A, chromosome 7 at 7,295,091 bp
  • A to G, chromosome 7 at 19,307,385 bp
  • A to G, chromosome 7 at 28,898,264 bp
  • G to T, chromosome 7 at 135,669,845 bp
  • T to C, chromosome 8 at 13,133,790 bp
  • C to A, chromosome 8 at 105,295,300 bp
  • A to T, chromosome 9 at 71,917,027 bp
  • A to G, chromosome 10 at 18,165,475 bp
  • A to G, chromosome 10 at 78,791,233 bp
  • T to A, chromosome 10 at 126,010,192 bp
  • C to T, chromosome 10 at 128,799,003 bp
  • C to T, chromosome 11 at 4,075,547 bp
  • A to G, chromosome 11 at 49,564,848 bp
  • T to A, chromosome 11 at 83,429,056 bp
  • A to T, chromosome 11 at 84,510,425 bp
  • A to G, chromosome 11 at 88,210,154 bp
  • C to T, chromosome 11 at 119,326,698 bp
  • T to A, chromosome 12 at 54,911,387 bp
  • T to C, chromosome 12 at 72,094,035 bp
  • A to G, chromosome 13 at 8,974,961 bp
  • C to T, chromosome 13 at 38,656,186 bp
  • T to C, chromosome 13 at 43,425,123 bp
  • A to T, chromosome 14 at 23,508,052 bp
  • A to T, chromosome 14 at 26,962,854 bp
  • T to A, chromosome 14 at 31,495,315 bp
  • T to C, chromosome 14 at 54,978,876 bp
  • T to A, chromosome 14 at 62,419,140 bp
  • A to T, chromosome 15 at 9,716,359 bp
  • T to A, chromosome 15 at 55,055,790 bp
  • G to A, chromosome 15 at 89,285,787 bp
  • T to C, chromosome 16 at 10,560,022 bp
  • A to T, chromosome 16 at 22,078,730 bp
  • A to T, chromosome 16 at 34,171,379 bp
  • A to G, chromosome 16 at 58,445,359 bp
  • G to A, chromosome 16 at 63,595,746 bp
  • A to G, chromosome 17 at 12,235,128 bp
  • C to T, chromosome 19 at 17,329,117 bp
  • A to G, chromosome 19 at 18,636,150 bp
  • A to T, chromosome 19 at 33,749,551 bp
  • C to A, chromosome 19 at 40,187,086 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038448-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.