Strain Name:
C57BL/6J-MtgxR0280Btlr/Mmmh
Stock Number:
038502-MU
Citation ID:
RRID:MMRRC_038502-MU
Other Names:
R0280 (G1), C57BL/6J-MtgxR0280Btlr
Major Collection:

Gene Information

Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: Su(Fu), 2810026F04Rik, b2b273Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 24069
Homologene: 9262
Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269132
Homologene: 22865
Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: Zfp294, 4930528H02Rik, Rnf160, Listerin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 78913
VEGA: 16
Homologene: 32272
Rps6kc1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: B130003F20Rik, RPK118
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320119
Homologene: 8244
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Esr1
Name: estrogen receptor 1 (alpha)
Synonyms: Nr3a1, Estra, ERalpha, Estr, ER-alpha, ERa, ER[a], ESR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13982
HGNC: HGNC:3467
Homologene: 47906
Nkapd1
Name: NKAP domain containing 1
Synonyms: LOC270156, AU019823
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270156
Homologene: 41233
Mphosph10
Name: M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Synonyms: 5730405D16Rik, 2810453H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67973
HGNC: HGNC:7213
Homologene: 134741
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, eyes2, crf11, QBRICK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329872
Homologene: 27049
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16576
Homologene: 72555
Drg1
Name: developmentally regulated GTP binding protein 1
Synonyms: Nedd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13494
HGNC: HGNC:3029
Homologene: 3060
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 53333
Homologene: 101105
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 77480
VEGA: 12
Homologene: 14254
Fcsk
Name: fucose kinase
Synonyms: Fuk, L-fucose kinase, 1110046B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234730
Homologene: 15452
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70083
VEGA: 17
Homologene: 11432
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329628
Homologene: 14377
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 546071
Homologene: 66191
Vsig8
Name: V-set and immunoglobulin domain containing 8
Synonyms: EG240916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240916
Homologene: 18616
Ttc25
Name: tetratricopeptide repeat domain 25
Synonyms: 4933404O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74407
Homologene: 12860
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 212392
Homologene: 17668
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: NHE3, NHE-3, 9030624O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105243
VEGA: 13
Homologene: 55804
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381260
Homologene: 124277
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Ccdc170
Name: coiled-coil domain containing 170
Synonyms: LOC237250, Gm221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100504234
Homologene: 69393
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230872
Homologene: 16811
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 171405
Homologene: 77136
1700061G19Rik
Name: RIKEN cDNA 1700061G19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78625
Homologene: 28378
Raet1d
Name: retinoic acid early transcript delta
Synonyms: RAE-1delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56554
Homologene: 134115
Ankrd16
Name: ankyrin repeat domain 16
Synonyms: D430029B21Rik, 2810455F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320816
Homologene: 19509
Olfr1279
Name: olfactory receptor 1279
Synonyms: MOR245-12, GA_x6K02T2Q125-72357646-72358581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258388
Homologene: 121520
Fut9
Name: fucosyltransferase 9
Synonyms: mFuc-TIX, mFUT9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 260305
Homologene: 9024
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231147
Homologene: 10360
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384220
Homologene: 104825
Nanog
Name: Nanog homeobox
Synonyms: ecat4, 2410002E02Rik, ENK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71950
Homologene: 78027
Dyrk1b
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
Synonyms: Mirk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13549
HGNC: HGNC:3092
Homologene: 31253
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620697
Homologene: 115466
Sgf29
Name: SAGA complex associated factor 29
Synonyms: 1700023O11Rik, Ccdc101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75565
Homologene: 12607
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 2310039H16Rik, 3110007G05Rik, B130050I23Rik, 1700084G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 213027
Homologene: 134635
Polb
Name: polymerase (DNA directed), beta
Synonyms: A430088C08Rik, Pol beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18970
HGNC: HGNC:9174
Homologene: 2013
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • GCC to GC, chromosome 1 at 59,544,680 bp
  • T to A, chromosome 1 at 128,162,775 bp
  • G to T, chromosome 1 at 152,508,561 bp
  • A to G, chromosome 1 at 172,561,538 bp
  • T to C, chromosome 1 at 190,809,000 bp
  • T to G, chromosome 2 at 11,781,501 bp
  • C to T, chromosome 2 at 76,740,479 bp
  • T to C, chromosome 2 at 111,307,072 bp
  • A to T, chromosome 3 at 38,890,816 bp
  • C to T, chromosome 4 at 25,619,852 bp
  • T to C, chromosome 4 at 82,969,444 bp
  • T to C, chromosome 4 at 141,028,426 bp
  • A to G, chromosome 4 at 148,008,715 bp
  • T to A, chromosome 4 at 152,551,936 bp
  • G to A, chromosome 5 at 22,227,513 bp
  • A to G, chromosome 5 at 35,706,017 bp
  • A to G, chromosome 5 at 109,340,139 bp
  • A to G, chromosome 6 at 122,713,398 bp
  • G to A, chromosome 7 at 19,713,751 bp
  • T to C, chromosome 7 at 28,184,312 bp
  • C to A, chromosome 7 at 64,376,703 bp
  • A to G, chromosome 7 at 79,698,823 bp
  • T to A, chromosome 7 at 85,233,249 bp
  • C to G, chromosome 7 at 85,233,258 bp
  • A to G, chromosome 7 at 126,671,571 bp
  • T to C, chromosome 8 at 4,193,133 bp
  • A to T, chromosome 8 at 16,271,602 bp
  • A to T, chromosome 8 at 22,640,392 bp
  • C to T, chromosome 8 at 24,674,054 bp
  • A to T, chromosome 8 at 45,943,450 bp
  • A to G, chromosome 8 at 70,783,795 bp
  • A to G, chromosome 8 at 70,787,920 bp
  • A to T, chromosome 8 at 110,894,748 bp
  • A to G, chromosome 9 at 13,799,249 bp
  • T to C, chromosome 9 at 50,609,379 bp
  • T to C, chromosome 10 at 4,558,663 bp
  • A to G, chromosome 10 at 4,856,951 bp
  • G to T, chromosome 10 at 4,939,289 bp
  • T to A, chromosome 10 at 22,370,883 bp
  • A to T, chromosome 11 at 3,256,537 bp
  • T to C, chromosome 11 at 97,241,014 bp
  • A to T, chromosome 11 at 100,550,265 bp
  • T to G, chromosome 11 at 119,284,547 bp
  • A to G, chromosome 12 at 25,010,141 bp
  • T to A, chromosome 13 at 74,159,424 bp
  • C to T, chromosome 15 at 55,586,461 bp
  • A to G, chromosome 16 at 87,397,838 bp
  • T to C, chromosome 16 at 97,039,006 bp
  • C to T, chromosome 17 at 25,795,135 bp
  • A to G, chromosome 17 at 50,607,034 bp
  • T to A, chromosome 17 at 56,885,169 bp
  • A to T, chromosome 19 at 7,896,822 bp
  • A to T, chromosome 19 at 46,450,673 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0280 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038502-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.