Strain Name:
C57BL/6J-MtgxR0311Btlr/Mmmh
Stock Number:
038521-MU
Citation ID:
RRID:MMRRC_038521-MU
Other Names:
R0311 (G1), C57BL/6J-MtgxR0311Btlr
Major Collection:

Gene Information

Th
Name: tyrosine hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21823
Homologene: 307
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: Jmjd2b, 4732474L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193796
Homologene: 27773
Tpx2
Name: TPX2, microtubule-associated
Synonyms: 2610005B21Rik, DIL2, REPP86, p100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Etl4
Name: enhancer trap locus 4
Synonyms: 6620402G01Rik, E330027G05Rik, Etl-4, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Mbtd1
Name: mbt domain containing 1
Synonyms: hemp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103537
Homologene: 41185
G3bp1
Name: GTPase activating protein (SH3 domain) binding protein 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27041
Homologene: 38096
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: Mi-2beta, D6Ertd380e, 9530019N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Abr
Name: active BCR-related gene
Synonyms: 6330400K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 109934
HGNC: HGNC:81
Homologene: 11081
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228545
Homologene: 13302
Adgrb2
Name: adhesion G protein-coupled receptor B2
Synonyms: Bai2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230775
HGNC: HGNC:944
Homologene: 1288
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Semaq, VIa, sema, Sema6A-1, A730020P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20358
Homologene: 32426
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Med23
Name: mediator complex subunit 23
Synonyms: X83317, ESTM7, 3000002A17Rik, Sur2, Crsp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Pym1
Name: PYM homolog 1, exon junction complex associated factor
Synonyms: A030010B05Rik, PYM Protein, Pym, Wibg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78428
VEGA: 10
Homologene: 41788
Fbxw11
Name: F-box and WD-40 domain protein 11
Synonyms: BTRC2, BTRCP2, Fbxw1b, 2310065A07Rik, HOS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103583
Homologene: 76444
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231386
Homologene: 15796
Gdpd3
Name: glycerophosphodiester phosphodiesterase domain containing 3
Synonyms: 1110015E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68616
Homologene: 23441
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: Mdr2, mdr-2, Pgy2, Pgy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1279Clo, Dnahc11, b2b598Clo, lrd, b2b1727Clo, b2b1203Clo, b2b1289Clo, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
AC159748.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Plpp2
Name: phospholipid phosphatase 2
Synonyms: Lpp2, Ppap2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50784
HGNC: HGNC:9230
Homologene: 2752
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Tmx4
Name: thioredoxin-related transmembrane protein 4
Synonyms: D2Bwg1356e, 4930500L08Rik, Txndc13, 2810417D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 52837
Homologene: 10901
Tnxb
Name: tenascin XB
Synonyms: TN-MHC, Tnx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: D17Ertd479e, EGF-TM7, FIRE, Emr4, Gpr127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620928
Homologene: 115466
Olfr910
Name: olfactory receptor 910
Synonyms: MOR165-3, GA_x6K02T2PVTD-32239063-32239995
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258807
VEGA: 9
Homologene: 115510
Tnfrsf18
Name: tumor necrosis factor receptor superfamily, member 18
Synonyms: Gitr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21936
Homologene: 48270
Speg
Name: SPEG complex locus
Synonyms: SPEG, Apeg1, BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Olfr1448
Name: olfactory receptor 1448
Synonyms: MOR202-5, GA_x6K02T2RE5P-3249780-3248836
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258696
Homologene: 64904
Asprv1
Name: aspartic peptidase, retroviral-like 1
Synonyms: SASPase, 2300003P22Rik, SASP, Taps, TPA-induced aspartic proteinase-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67855
Homologene: 23582
Fktn
Name: fukutin
Synonyms: Fcmd, Fukutin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 246179
HGNC: HGNC:3622
Homologene: 31402
Cd48
Name: CD48 antigen
Synonyms: Sgp-60, BCM1, Bcm-1, BLAST-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Rnf207
Name: ring finger protein 207
Synonyms: D330010C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433809
Homologene: 19234
Ccdc89
Name: coiled-coil domain containing 89
Synonyms: 1700019B01Rik, BOIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70054
Homologene: 17653
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67307
Hexb
Name: hexosaminidase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15212
VEGA: 13
HGNC: HGNC:4879
Homologene: 437
Erich5
Name: glutamate rich 5
Synonyms: BC030476
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239368
VEGA: 15
Homologene: 52129
RP24-245M20.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Olfr1444
Name: olfactory receptor 1444
Synonyms: MOR202-4, GA_x6K02T2RE5P-3191201-3192160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258697
Homologene: 64906
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,430,937 bp
  • C to A, chromosome 1 at 171,699,580 bp
  • A to G, chromosome 2 at 20,807,129 bp
  • T to C, chromosome 2 at 119,297,365 bp
  • T to A, chromosome 2 at 134,598,526 bp
  • T to C, chromosome 2 at 152,890,492 bp
  • T to C, chromosome 3 at 144,932,496 bp
  • A to G, chromosome 4 at 53,744,620 bp
  • G to C, chromosome 4 at 130,017,129 bp
  • A to G, chromosome 4 at 152,315,779 bp
  • T to C, chromosome 4 at 156,026,415 bp
  • A to G, chromosome 5 at 8,934,243 bp
  • A to T, chromosome 5 at 63,804,998 bp
  • G to A, chromosome 5 at 86,835,705 bp
  • T to C, chromosome 6 at 86,628,840 bp
  • T to C, chromosome 6 at 125,101,665 bp
  • A to G, chromosome 7 at 85,871,789 bp
  • A to G, chromosome 7 at 90,426,693 bp
  • A to C, chromosome 7 at 120,402,904 bp
  • G to A, chromosome 7 at 126,767,189 bp
  • T to C, chromosome 7 at 142,896,041 bp
  • C to G, chromosome 8 at 109,623,649 bp
  • G to A, chromosome 8 at 109,623,663 bp
  • T to C, chromosome 9 at 38,539,297 bp
  • T to A, chromosome 10 at 5,348,943 bp
  • T to A, chromosome 10 at 24,897,358 bp
  • T to C, chromosome 10 at 63,054,507 bp
  • C to T, chromosome 10 at 79,527,580 bp
  • G to T, chromosome 10 at 128,765,984 bp
  • A to G, chromosome 11 at 32,722,083 bp
  • T to C, chromosome 11 at 55,498,626 bp
  • A to G, chromosome 11 at 76,509,127 bp
  • T to A, chromosome 11 at 93,921,357 bp
  • A to T, chromosome 12 at 118,127,133 bp
  • A to G, chromosome 13 at 97,183,819 bp
  • A to G, chromosome 15 at 34,472,939 bp
  • A to T, chromosome 17 at 34,716,984 bp
  • A to T, chromosome 17 at 55,802,010 bp
  • A to G, chromosome 17 at 56,386,200 bp
  • G to A, chromosome 18 at 47,290,045 bp
  • T to C, chromosome 19 at 4,787,556 bp
  • A to G, chromosome 19 at 12,861,869 bp
  • T to A, chromosome 19 at 12,920,096 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0311 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038521-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.