Strain Name:
C57BL/6J-MtgxR0315Btlr/Mmmh
Stock Number:
038525-MU
Citation ID:
RRID:MMRRC_038525-MU
Other Names:
R0315 (G1), C57BL/6J-MtgxR0315Btlr
Major Collection:

Gene Information

Map2k5
Name: mitogen-activated protein kinase kinase 5
Synonyms: MEK5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23938
VEGA: 9
HGNC: HGNC:6845
Homologene: 115933
Runx1
Name: runt related transcription factor 1
Synonyms: AML1, Pebp2a2, runt domain, alpha subunit 2, Cbfa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12394
Homologene: 1331
Cd86
Name: CD86 antigen
Synonyms: B7-2, MB7-2, B70, Ly-58, Cd28l2, B7.2, Ly58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12524
HGNC: HGNC:1705
Homologene: 10443
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Ube2h
Name: ubiquitin-conjugating enzyme E2H
Synonyms: E2-20K, 1500009C23Rik, Ubc8, Gid3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22214
Homologene: 103894
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73274
Homologene: 11292
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: Fbx13, C130023C01Rik, 6330576B01Rik, Fbxo13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50758
Homologene: 79859
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Prc1
Name: protein regulator of cytokinesis 1
Synonyms: D7Ertd348e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233406
HGNC: HGNC:9341
Homologene: 37868
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, Adtg, D8Ertd374e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Soat1
Name: sterol O-acyltransferase 1
Synonyms: ACAT-1, Acact, 8430426K15Rik, hid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20652
Homologene: 2333
Gm6712
Name: predicted gene 6712
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100862203
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Klhl2
Name: kelch-like 2, Mayven
Synonyms: ABP-KELCH, 6030411N21Rik, Mav, 8530402H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77113
HGNC: HGNC:6353
Homologene: 21416
Dpys
Name: dihydropyrimidinase
Synonyms: DHPase, 1300004I01Rik, 1200017I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64705
HGNC: HGNC:3013
Homologene: 20359
Nop53
Name: NOP53 ribosome biogenesis factor
Synonyms: 9430097C02Rik, Gltscr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68077
HGNC: HGNC:4333
Homologene: 44130
Susd4
Name: sushi domain containing 4
Synonyms: E430021N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96935
Homologene: 23062
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Tm4sf5
Name: transmembrane 4 superfamily member 5
Synonyms: 2010003F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75604
Homologene: 2947
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Olfr799
Name: olfactory receptor 799
Synonyms: GA_x6K02T2PULF-11325750-11326685, MOR114-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258929
Homologene: 37000
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229574
Homologene: 134146
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Olfr1153
Name: olfactory receptor 1153
Synonyms: GA_x6K02T2Q125-49395950-49396882, MOR177-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258633
Homologene: 27230
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Pla2g4b
Name: phospholipase A2, group IVB (cytosolic)
Synonyms: A030011C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211429
HGNC: HGNC:9036
Homologene: 3730
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4930432K16Rik, 4921529O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78257
Homologene: 12692
Adora3
Name: adenosine A3 receptor
Synonyms: A3AR, ARA3, Gpcr 2, 4930578J19Rik, AA3R, A3R, 1700001D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11542
HGNC: HGNC:268
Homologene: 550
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Stat5b
Name: signal transducer and activator of transcription 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20851
Homologene: 55718
Mpv17l
Name: Mpv17 transgene, kidney disease mutant-like
Synonyms: M-LP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 93734
Homologene: 13547
Slc16a14
Name: solute carrier family 16 (monocarboxylic acid transporters), member 14
Synonyms: 1110004H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71781
Homologene: 34318
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 328505
Homologene: 106613
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21897
Homologene: 20694
Ing2
Name: inhibitor of growth family, member 2
Synonyms: 2810011M06Rik, P33ING2, ING2, Ing1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69260
HGNC: HGNC:6063
Homologene: 20388
Olfr370
Name: olfactory receptor 370
Synonyms: GA_x6K02T2NUPS-11609807-11610751, MOR267-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 258267
Homologene: 74037
Rdh7
Name: retinol dehydrogenase 7
Synonyms: CRAD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54150
Homologene: 137324
Hmgn1
Name: high mobility group nucleosomal binding domain 1
Synonyms: Hmg14, HMG-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15312
HGNC: HGNC:4984
Homologene: 3643
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619788
Homologene: 86604
Olfr1447
Name: olfactory receptor 1447
Synonyms: GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258698
Homologene: 74233
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 72,595,811 bp
  • T to C, chromosome 1 at 75,415,136 bp
  • T to C, chromosome 1 at 84,912,496 bp
  • T to A, chromosome 1 at 156,440,513 bp
  • G to A, chromosome 1 at 182,858,512 bp
  • A to T, chromosome 2 at 87,897,066 bp
  • A to T, chromosome 2 at 118,626,976 bp
  • T to C, chromosome 2 at 120,039,057 bp
  • G to T, chromosome 3 at 93,214,722 bp
  • T to A, chromosome 3 at 105,916,769 bp
  • T to A, chromosome 4 at 55,079,314 bp
  • G to A, chromosome 4 at 111,988,118 bp
  • T to G, chromosome 5 at 64,926,928 bp
  • T to A, chromosome 5 at 104,459,850 bp
  • A to T, chromosome 6 at 30,241,413 bp
  • T to C, chromosome 7 at 15,945,310 bp
  • T to C, chromosome 7 at 80,313,536 bp
  • A to C, chromosome 8 at 47,669,090 bp
  • A to T, chromosome 8 at 64,743,019 bp
  • T to C, chromosome 8 at 83,541,372 bp
  • A to G, chromosome 8 at 109,819,035 bp
  • A to T, chromosome 9 at 63,303,151 bp
  • A to T, chromosome 10 at 70,002,517 bp
  • A to G, chromosome 10 at 88,807,421 bp
  • G to T, chromosome 10 at 127,888,396 bp
  • T to A, chromosome 10 at 129,647,497 bp
  • A to G, chromosome 11 at 70,510,636 bp
  • G to C, chromosome 11 at 100,788,460 bp
  • A to G, chromosome 12 at 72,456,028 bp
  • A to T, chromosome 13 at 99,431,116 bp
  • T to G, chromosome 13 at 111,436,538 bp
  • T to G, chromosome 15 at 39,857,338 bp
  • T to C, chromosome 15 at 59,341,976 bp
  • C to T, chromosome 15 at 76,427,600 bp
  • A to T, chromosome 16 at 13,940,999 bp
  • C to T, chromosome 16 at 36,620,944 bp
  • T to C, chromosome 16 at 92,605,767 bp
  • A to C, chromosome 16 at 96,124,817 bp
  • G to A, chromosome 17 at 17,316,118 bp
  • G to A, chromosome 17 at 23,460,165 bp
  • G to A, chromosome 17 at 45,515,452 bp
  • G to A, chromosome 17 at 63,356,851 bp
  • A to T, chromosome 19 at 12,901,234 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0315 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038525-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.